Facteurs liés au signalement des évènements indésirables associés aux soins dans un hôpital tunisien

Abstract

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Factors Associated with Underreporting of Adverse Drug Reactions by Health Care Professionals: A Systematic Review Update

“…More than half of the articles (45/65, 69.2%) were cross-sectional studies [ 13 , 14 , 16 – 19 , 21 – 24 , 26 – 39 , 41 , 42 , 44 , 45 , 47 – 51 , 54 – 56 , 59 – 61 , 64 , 65 , 69 – 71 , 74 ], 21.5% did not indicate the design type used [ 20 , 25 , 52 , 57 , 58 , 62 , 63 , 66 – 68 , 72 , 73 , 75 , 76 ], 4.6% were case-control studies [ 40 , 46 , 77 ] (during the same period, the cases had reported ADR and the controls had not), 3.1% (2/65) were mixed studies [ 15 , 43 ] (only data from the quantitative part were used), and one (1.5%) was an intervention study [ 53 ] (pre-intervention data were extracted). Two studies were conducted before a pharmacovigilance system was in place [ 17 , 31 ].…”

“…According to geographical distribution, we located studies carried out in 36 countries: 38.5% were carried out in Asia [ 19 , 22 , 28 , 29 , 31 , 32 , 35 , 37 – 39 , 44 , 46 , 47 , 50 – 53 , 56 , 58 , 59 , 61 , 63 – 65 , 72 ], 27.7% in Africa [ 13 – 15 , 17 , 18 , 23 , 27 , 30 , 34 , 42 , 45 , 48 , 49 , 65 , 69 – 71 , 74 ], 24.6% in Europe [ 20 , 21 , 24 , 25 , 33 , 40 , 43 , 54 , 55 , 57 , 60 , 62 , 66 , 73 , 75 , 77 ], 7.7% in America [ 16 , 36 , 41 , 67 , 76 ], and one in Australia [ 27 ].…”

“…Regarding the setting where the study was performed, 43.1% took place in hospitals [ 14 , 15 , 17 – 19 , 22 , 24 , 30 , 32 , 35 , 41 – 44 , 46 – 48 , 53 , 56 , 59 , 63 , 64 , 66 , 68 – 70 , 73 , 74 ], 21.5% in pharmacies [ 20 , 21 , 26 , 31 , 33 , 38 , 39 , 51 , 61 , 65 , 72 , 75 – 77 ], 9.2% did not mention the place [ 16 , 25 , 52 , 55 , 57 , 62 ], 6.2% in hospitals and pharmacies [ 28 , 50 , 67 , 71 ], and 6.2% in primary care [ 13 , 23 , 27 , 29 ]. In 10 articles, the results of surveys carried out in two different health facilities are combined [ 28 , 34 , 36 , 37 , 40 , 49 , 50 , 54 , 67 , 71 ].…”

“…In the articles that mentioned response rate, this varied between 16.4% [ 67 ] and 100% [ 17 , 22 , 23 , 34 , 63 , 76 ] (see Online Resource Table S2). More than half of the articles had response rates > 50% [ 13 – 15 , 17 – 24 , 28 – 35 , 37 , 38 , 41 – 44 , 46 , 48 – 50 , 54 , 56 , 58 , 59 , 61 , 63 – 65 , 68 , 70 – 77 ], and six reached 100% [ 17 , 22 , 23 , 34 , 63 , 76 ]; nine articles did not mention the response rate [ 16 , 26 , 27 , 39 , 45 , 47 , 62 , 66 , 69 ].…”

“…The survey was distributed personally in more than half of the articles [ 13 – 15 , 17 – 20 , 22 – 24 , 27 – 31 , 37 – 39 , 41 , 42 , 44 , 47 – 51 , 53 , 54 , 56 , 58 , 59 , 61 , 62 , 64 , 65 , 72 , 74 , 76 , 77 ], and the remainder were sent by internet [ 16 , 25 , 26 , 33 , 35 , 36 , 39 , 52 , 57 , 62 ] or post [ 21 , 33 , 40 , 46 , 55 , 60 , 67 , 73 ], while 10.8% did not mention how the survey was distributed [ 32 , 34 , 43 , 45 , 63 , 69 , 71 ]. In four articles, two or more distribution types were combined [ 33 , 35 , 39 , 62 ] (see Online Resource Table S1)…”