Factitious Respiratory Failure: Bound to the Ventilator by Pressure Support

Conci, Diego; Fortis, Spyridon; Ramos, Frederick; Ong, Philip; Balasingham, Shiva; Manthous, Constantine A.

doi:10.1164/ajrccm.182.9.1208

Cited by 1 publication

(1 citation statement)

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“…Specific strategies have been associated with the effective recruitment and retention of minority research participants (14). Ethnic and cultural background has been shown to affect perceptions of disease, understanding of disease and even perception of pulmonary function (15). …”

Section: Challenges With Cross-age Studiesmentioning

confidence: 99%

Researching asthma across the ages: Insights from the National Heart, Lung, and Blood Institute’s Asthma Network

Cabana

Kunselman

Nyenhuis

et al. 2014

Journal of Allergy and Clinical Immunology

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Clinical asthma studies across different age groups, or ‘cross-age’ studies, can potentially offer insight into the similarities, differences and relationships between childhood and adult asthma. The National Institutes of Health Asthma Research Network (AsthmaNet) is unique and innovative in that it has merged pediatric and adult asthma research into one clinical research network. This combination enhances scientific exchange between pediatric and adult asthma investigators and encourages the application of ‘cross-age’ studies that involve participants from multiple age groups who are generally not studied together. The experience from AsthmaNet in the development of ‘cross-age’ protocols highlights some of the issues in the evaluation of cross-age research in asthma. The aim of this review is to summarize these challenges, including the selection of parallel, cross-age clinical interventions, identification of appropriate controls, measurement of meaningful clinical outcomes, as well as various ethical and logistical issues.

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Section: Challenges With Cross-age Studiesmentioning

confidence: 99%