Factor Analysis of Biochemical Markers Associated with Bone Mineral Density          in Adults

Cho, Jae-Hwan; Kim, Min-Tae; Lee, Hae-Kag; Hong, In-Sik; Jang, Hyonchol

doi:10.1589/jpts.26.1225

Cited by 14 publications

(12 citation statements)

References 20 publications

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“…The strength of healthy bone can be assessed by continuous measurements of bone quality, bone mineral density (BMD), and bone structure 1 , 2 ) . Currently, these parameters are considered the ideal controlled measures of bone strength in normal and diseased bone cases 3 , 4 , 5 ) .…”

Section: Introductionmentioning

confidence: 99%

Physical activity and lifestyle effects on bone mineral density among young adults: sociodemographic and biochemical analysis

2015

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[Purpose] The purpose of this study was to assess the possible role of physical activities, calcium consumption and lifestyle factors in both bone mineral density and bone metabolism indices in 350 young adult volunteers. [Subjects and Methods] All volunteers were recruited for the assessment of lifestyle behaviors and physical activity traits using validated questioners, and bone mineral density (BMD), serum osteocalcin (s-OC), bone-specific alkaline phosphatase (BAP), and calcium were estimated using dual-energy X-ray absorptiometry analysis, and immunoassay techniques. [Results] Male participants showed a significant increase in BMD along with an increase in bone metabolism markers compared with females in all groups. However, younger subjects showed a significant increase in BMD, OC, BAP, and calcium compared with older subjects. Osteoporosis was more common in older subjects linked with abnormal body mass index and waist circumference. Bone metabolism markers correlated positively with BMD, physically activity and negatively with osteoporosis in all stages. Also, moderate to higher calcium and milk intake correlated positively with higher BMD. However, low calcium and milk intake along with higher caffeine, and carbonated beverage consumption, and heavy cigarette smoking showed a negative effect on the status of bone mineral density. Stepwise regression analysis showed that life style factors including physical activity and demographic parameters explained around 58–69.8% of the bone mineral density variation in young adults especially females. [Conclusion] body mass index, physical activity, low calcium consumption, and abnormal lifestyle have role in bone mineral density and prognosis of osteoporosis in young adults.

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Section: Introductionmentioning

confidence: 99%

Physical activity and lifestyle effects on bone mineral density among young adults: sociodemographic and biochemical analysis

2015

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“…Osteoporosis is a systemic disease which is characterized by decreased bone mass, destructed bone microstructure, and increased osteopsathyrosis. Osteoporosis is related to biomechanics loading, hormone and local biochemistry cytokines. Osteoporosis is a common disease which is predicted to affect 400 mn people, accounting for 27% of the whole population.…”

Section: Discussionmentioning

confidence: 99%

Dynamic Change of Lumbar Structure and Associated Factors: A Retrospective Study

Wei

Zhu

Zhao

et al. 2019

Orthopaedic Surgery

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Objective: To determine whether lumbar anatomy parameters are in dynamic change and related factors.Methods: This is a retrospective study. Participants who did lumbar computed tomography (CT) scanning in Shandong University Qilu Hospital from October 2017 to March 2019 were selected. The 476 participants were randomly selected as male or female, with the age ranging from 17 to 87 years (mean, 55.19; standard deviation, 14.28 years). All the measurements were taken based on the CT scanning image and the measurement of lumbar morphology was conducted using picture archiving and communication systems (PACS). The angle between the horizontal alignment and pedicle center on median sagittal view, the angle between upper endplate and lower endplate on median sagittal view as well as transverse section angle (TSA) using Magerl point in the axial view was determined by reconstructive CT analysis.Results: In the overall participants, the angle between the horizontal alignment and pedicle center on median sagittal view of lumbar one to three was significantly decreased with aging, from 3.90 AE 2.81 to −4.18 AE 6.86 (P = 0.002), 5.60 AE 2.89 to −4.14 AE 5.90 (P = 0.030), and 4.75 AE 2.95 to −2.87 AE 4.68 (P < 0.001), respectively. Additionally, the angle between the horizontal alignment and pedicle center on median sagittal view in male participants of lumbar two was dramatically decreased, from 4.83 AE 2.79 to −4.45 AE 5.97 (P = 0.30). And that of lumbar three in female participants was significantly decreased, from 4.56 AE 2.52 to −2.88 AE 5.03 (P = 0.029). Furthermore, of the overall participants, the angle between upper endplate and lower endplate on median sagittal view of lumbar one to four was associated with aging (P < 0.001, P < 0.001, P = 0.015, P < 0.001, respectively). The angle of lumbar one, two and four in male participants and lumbar one to four in female participants were all significantly related to aging (all P < 0.05). Moreover, in the participants overall, the TSA of lumbar one to three was significantly associated with aging (P = 0.015, P = 0.006 and P = 0.007, respectively). In addition, this angle in lumbar one to lumbar four in male participants were all negatively associated with aging (P = 0.017, P = 0.001, P = 0.005 and P = 0.036, respectively). Conclusion:Lumbar anatomy parameters are in dynamic change in an age and gender dependent manner. During spine surgery in elderly patients, more attention should be paid to these anatomic changes.

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“…Maillefert et al investigated the role of side effects in physical restriction, the inflammatory process, and drug therapy in the development of osteoporosis in AS and emphasized that the inflammatory process contributed to loss of bone mass 10 ) . Genetic factors, immobilization, drugs used, changes in calcium metabolism, and hormonal balances have also been implicated 11 ) . In addition to osteopenia and osteoporosis, new bone formation or ligament calcifications lead to loss of flexibility in the vertebral column.…”

Section: Discussionmentioning

confidence: 99%

Association between mean platelet volume and bone mineral density in patients with ankylosing spondylitis and diagnostic value of diffusion-weighted magnetic resonance imaging

Reşorlu

Gökmen

et al. 2015

J Phys Ther Sci

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[Purpose] The aim this study was to assess the relation between bone mineral density (BMD) and mean platelet volume (MPV) in ankylosing spondylitis (AS) patients, and evaluate the diagnostic role of the diffusion-weighted magnetic resonance imaging (MRI). [Subjects and Methods] Fifty patients diagnosed with AS were divided into two groups on the basis of BMD, a normal group (n=30) and an osteopenic (n=20) group. [Results] Duration of disease in the group with a normal BMD was 10.3±7.0 years, while it was 16.7±12.2 years in the osteopenia group. MPV was high in the osteopenia group, while no significant differences were observed between the groups in terms of apparent diffusion coefficient (ADC) and platelet distribution width (PDW). There was a positive correlation between MPV and duration of disease. Correlations between ADC value and the lumbar T score, femoral neck T score, and duration of disease were insignificant. A negative correlation was observed between BMD and disease duration. [Conclusion] Diffusion-weighted imaging provides valuable results in osteoporosis but is not a suitable technique for evaluating BMD in patients with AS because of the local and systemic inflammatory effects in the musculoskeletal system. The common pathophysiology of atherosclerosis and osteoporosis plays an important role in the negative correlation observed between MPV and BMD in patients with AS.

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Factor Analysis of Biochemical Markers Associated with Bone Mineral Density in Adults

Cited by 14 publications

References 20 publications

Physical activity and lifestyle effects on bone mineral density among young adults: sociodemographic and biochemical analysis

Physical activity and lifestyle effects on bone mineral density among young adults: sociodemographic and biochemical analysis

Dynamic Change of Lumbar Structure and Associated Factors: A Retrospective Study

Association between mean platelet volume and bone mineral density in patients with ankylosing spondylitis and diagnostic value of diffusion-weighted magnetic resonance imaging

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