Factor analysis of elevated plus-maze behavior in adolescent and adult rats

Doremus, Tamara L.; Spear, Linda P.

doi:10.1016/j.pbb.2006.03.019

Cited by 71 publications

(59 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This dissociation between activity and anxiety like behaviors was also found in a number of studies examining rodent behavior in the elevated plus maze, with researchers reporting general activity variables loading onto a separate factor from anxiety-like behaviors [1,12,18]. The difference among the four groups is in the order of these two fac-tors.…”

Section: Principal Components Analysessupporting

confidence: 54%

Strain and Sex Differences in Anxiety-Like and Social Behaviors in C57BL/6J and BALB/cJ Mice

Zou

et al. 2011

Exp. Anim.

174

View full text Add to dashboard Cite

Abstract:Mood disorders are more frequent in women than men, however, the majority of research has focused on male rodents as animal models. We used a variety of common behavioral tests to look for differences in anxiety-like and social behaviors between and within C57BL/6J and BALB/cJ mice. Our results show that female C57BL/6J mice exhibited lower levels of anxiety-like behavior and higher levels of activity than female BALB/cJ during the open field and elevated plus maze tests. Principal component analysis generated more factors in the behavioral variables of males than females. In the open field, a sex difference was also found and factor 1 emerged as anxiety in males, and motor activity in females. While C57BL/6J mice were found to have higher levels of social exploration and social contacts, differences were found between the sexes (females were more social) in both strains for this measure and also for anxiety-like behaviors. When interacting with animals of the same sex, levels of sniffing body and huddling in both male and female C57BL/6J mice were higher than those in male and female BALB/cJ mice. However, in the between-sex interactions, male C57BL/6J mice sniffed the stimulus mouse less, and female C57BL/6J mice sniffed the stimulus more compared to BALB/cJ mice. This study provides important behavioral phenotypes and confirms the multidimensional behavioral structure of two widely used mice strains.

show abstract

Section: Principal Components Analysessupporting

confidence: 54%

Strain and Sex Differences in Anxiety-Like and Social Behaviors in C57BL/6J and BALB/cJ Mice

Zou

et al. 2011

Exp. Anim.

174

View full text Add to dashboard Cite

show abstract

“…Factorial analyses Two-fold exploratory factor analyses were used to obtain a continuous interval scale score by using principal components as an extraction method and the varimax rotation with the Kaiser normalization rotation (Doremus et al, 2006). Individual factor scores from the parameters of the EPM, OF/NO, LD and CC were calculated for each subject based on the relative weight and orientation (eigenvalues) of the loading of the parameters for each obtained factor.…”

Section: Statistical Analysesmentioning

confidence: 99%

Personality traits in rats predict vulnerability and resilience to developing stress-induced depression-like behaviors, HPA axis hyper-reactivity and brain changes in pERK1/2 activity

Castro

Diessler

Varea

et al. 2012

Psychoneuroendocrinology

View full text Add to dashboard Cite

Summary Emerging evidence indicates that certain behavioral traits, such as anxiety, are associated with the development of depression-like behaviors after exposure to chronic stress. However, single traits do not explain the wide variability in vulnerability to stress observed in outbred populations. We hypothesized that a combination of behavioral traits might provide a better characterization of an individual's vulnerability to prolonged stress. Here, we sought to determine whether the characterization of relevant behavioral traits in rats could aid in identifying individuals with different vulnerabilities to developing stress-induced depressionlike behavioral alterations. We also investigated whether behavioral traits would be related to the development of alterations in the hypothalamic-pituitary-adrenal axis and in brain activityas measured through phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) -in response to an acute stressor following either sub-chronic (2 weeks) or chronic (4 weeks) unpredictable stress (CUS). Sprague-Dawley rats were characterized using a battery of behavioral tasks, and three principal traits were identified: anxiety, exploration and activity. When combined, the first two traits were found to explain the variability in the stress responses. Our findings confirm the increased risk of animals with high anxiety developing certain depression-like behaviors (e.g., increased floating time in the forced swim test) when progressively exposed to stress. In contrast, the behavioral profile based on combined low anxiety and low exploration was resistant to alterations related to social behaviors, while the high anxiety and low exploration profile displayed a particularly vulnerable pattern of physiological and neurobiological responses after sub-chronic stress exposure. Our findings indicate important differences in

show abstract

“…While entries onto open arms and time spent on open arms were the parameters in focus of this study, both being tentative indices of "anxiety", the number of entries into closed arms was assessed as an index of general activity or locomotion (Doremus et al 2006). Entries into the centre of the maze, as well as total number of entries, were assessed as well.…”

Section: Elevated Plus Mazementioning

confidence: 99%

Serotonin depletion counteracts sex differences in anxiety-related behaviour in rat

et al. 2013

View full text Add to dashboard Cite

show abstract

Factor analysis of elevated plus-maze behavior in adolescent and adult rats

Cited by 71 publications

References 34 publications

Strain and Sex Differences in Anxiety-Like and Social Behaviors in C57BL/6J and BALB/cJ Mice

Strain and Sex Differences in Anxiety-Like and Social Behaviors in C57BL/6J and BALB/cJ Mice

Personality traits in rats predict vulnerability and resilience to developing stress-induced depression-like behaviors, HPA axis hyper-reactivity and brain changes in pERK1/2 activity

Serotonin depletion counteracts sex differences in anxiety-related behaviour in rat

Contact Info

Product

Resources

About