Factor II, VII, IX and X concentrations in patients receiving long term warfarin.

Abstract

Material and methods Thirty seven consecutive outpatients who had received warfarin for not less than three months were studied. There were 20 women aged 28-73 years (mean 60 years) and 17 men aged 28-78 years (mean 59 years). Eleven had been receiving warfarin for less than one year, while eight had been treated for longer than 10 years.

Levels of vitamin K-dependent procoagulant and anticoagulant proteins in over-anticoagulated patients

“…The pattern of procoagulant level reductions found in our therapeutically anticoagulated patients is in accordance with that of other studies [5,6,14]. The absence of a difference in factor II and factor VII in therapeutically anticoagulated patients on acenocoumarol may be explained by the fact that blood was collected 12-18 h after drug intake.…”

“…A number of studies has been carried out on the extent to which the different vitamin K-dependent procoagulant factors are depressed in patients on long-term oral anticoagulant therapy at therapeutic levels of anticoagulation [3][4][5][6]: factor X is most strongly reduced, and factor IX is least strongly reduced. However, to our knowledge, there are no reports that focus on the levels of these factors in over-anticoagulated patients.…”

Efficacy of Warfarin Reversal in Orthopedic Trauma Surgery Patients

“…Also, warfarin therapy does not result in uniform reduction of the vitamin K-dependent factors. 10 These differences are relevant in consideration of the rate of reversal of warfarin and were demonstrated in our study, with the large 95% confidence interval in the time to surgery. Administering vitamin K reverses the anticoagulant effect of warfarin because conversion to the activated form of vitamin K may occur by a warfarin-resistant enzyme pathway.…”

Poor correlation of supratherapeutic international normalised ratio and vitamin K‐dependent procoagulant factor levels during warfarin therapy

“…In a study of 37 patients, Paul et al (1987) found that FX levels were the lowest, FII levels intermediate and FVII and FIX levels the highest. Similar findings were also reported in 50 patients (Lind et al, 1997).…”