Factor structure of the Positive and Negative Syndrome Scale (PANSS) in Brazil: convergent validation of the Brazilian version

Higuchi, Cinthia Hiroko; Ortiz, Bruno Bertolucci; Berberian, Arthur de Almeida; Noto, Cristiano; Cordeiro, Quirino; Belangero, Síntia Iole; Pitta, José Cássio do Nascimento; Gadelha, Ary; Bressan, Rodrigo A.

doi:10.1590/1516-4446-2013-1330

Cited by 49 publications

(25 citation statements)

References 12 publications

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“…Symptom clusters (negative, positive, disorganization, excited and anxiety/depression) from the PANSS items 20 were calculated using the algorithm from a previous study in a Brazilian population 21 . For more information about each symptom cluster, see Supplementary Table S1.…”

Section: Methodsmentioning

confidence: 99%

“…With the PRSs calculated for the case-control comparison, we used a generalized linear model to test PRS associations assuming a Poisson distribution (Poisson regression), which is more suitable for ordinal variables (such as psychiatric scales), using clinical traits as the dependent variable and the best p -threshold PRS with the first four principal components as the independent variables and covariates. As clinical outcome variables, we considered, for both time points, GAF score, total CGI score, total PANSS scores and the five PANSS dimension clusters suggested by Wallwork et al 20 and validated by Higuchi et al 21 in the Brazilian population. GAF values were transformed to negative values (−GAF), so all clinical variables were easily compared, with high values meaning high symptomatology.…”

Section: Methodsmentioning

confidence: 99%

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Polygenic risk score analyses of symptoms and treatment response in an antipsychotic-naive first episode of psychosis cohort

et al. 2018

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In this study, we aimed to test if the schizophrenia (SCZ) polygenic risk score (PRS) was associated with clinical symptoms in (a) the first episode of psychosis pre-treatment (FEP), (b) at nine weeks after initiation of risperidone treatment (FEP-9W) and (c) with the response to risperidone. We performed a detailed clinical assessment of 60 FEP patients who were antipsychotic-naive and, again, after nine weeks of standardized treatment with risperidone. After blood collection and DNA isolation, the samples were genotyped using the Illumina PsychArrayChip and then imputed. To calculate PRS, we used the latest available GWAS summary statistics from the Psychiatric Genomics Consortium wave-2 SCZ group as a training set. We used Poisson regression to test association between PRS and clinical measurements correcting for the four principal components (genotyping). We considered a p-value < 0.0014 (Bonferroni correction) as significant. First, we verified that the schizophrenia PRS was also able to distinguish cases from controls in this south-eastern Brazilian sample, with a similar variance explained to that seen in Northern European populations. In addition, within-cases analyses, we found that PRS is significantly correlated with baseline (pre-treatment) symptoms, as measured by lower clinical global assessment of functioning (−GAF), higher depressive symptoms and higher scores on a derived excitement factor. After standardized treatment for nine weeks, the correlation with GAF and the excitement factor disappeared while depressive symptoms became negatively associated with PRS. We conclude that drug (and other treatments) may confound attempts to understand the aetiological influence on symptomatology of polygenic risk scores. These results highlight the importance of studying schizophrenia, and other disorders, pre-treatment to understand the relationship between polygenic risk and phenotypic features.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Polygenic risk score analyses of symptoms and treatment response in an antipsychotic-naive first episode of psychosis cohort

et al. 2018

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“…1). A non-parametric correlation to ACE enzymatic activity showed no significant correlation for any dimension (data not shown) in Positive and Negative Syndrome Scale (PANSS) for a Brazilian sample (Higuchi et al, 2014). We also looked for relation to severity using Clinical Global Impression (CGI) and Global Assessment of Functioning (GAF) values, and no significant correlation to ACE activity was found.…”

Section: Resultsmentioning

confidence: 93%

ACE I/D genotype-related increase in ACE plasma activity is a better predictor for schizophrenia diagnosis than the genotype alone

Gadelha

Yonamine

Ota

et al. 2015

Schizophrenia Research

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“…(SCID-IV) 27 . The patients were also evaluated with the Positive and Negative Syndrome Scale (PANSS) 28 , Calgary Depression Scale for Schizophrenia (CDSS) 29 , Clinical Global Impression, (CGI) 30 , and Global Assessment of Functioning (GAF) 31 . The patients were being treated with atypical antipsychotics, and medication dosages were stable for at least 4 weeks prior to cognitive assessment.…”

Section: Stage 3 -Study Of Psychometric Propertiesmentioning

confidence: 99%

“…Positive and Negative Syndrome Scale (PANSS) 28 : the PANSS was applied to the group for assessment of psychopathology. This measure includes 30 items: seven positive symptoms, seven negative symptoms and sixteen general psychopathology items.…”

Section: Instrumentsmentioning

confidence: 99%

Investigation of cognition in schizophrenia: psychometric properties of instruments for assessing working memory updating

Berberian

Gadelha

Dias

et al. 2015

J. bras. psiquiatr.

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Objective: This study describes the development of two updating measures of working memory (WM): Letter Updating Test (LUT) and Word Updating Test (WUT). Methods: In stage 1, items were created and the instruments were assessed by experts and laymen. In stage 2, tests were given to 15 patients with schizophrenia and 15 paired controls. All were able to understand and respond to the instruments. In stage 3, 141 patients with schizophrenia and 119 healthy controls aged 18 to 60 took part; they were assessed on WM, processing speed (PS) and functional outcome. Results: The results showed adequate rates of internal consistency for both measures developed, for both the total sample and each group separately, as well as evidence of convergent validity, discriminant validity and sensitivity to differentiate performance among the groups. Principal component analysis yielded two components, one for updating tests and other for PS measures, indicating factorial validity. Positive and significant, yet low, correlations were found with functionality measures. Conclusion: These results provide adequate psychometric parameters for the measures developed, applicable to cognitive research settings in schizophrenia. RESUMOObjetivo: O estudo descreve o desenvolvimento de duas medidas de atualização da memó-ria de trabalho (MT): Teste de Atualização de Letras (TAL) e Teste de Atualização de Palavras (TAP). Métodos: Na etapa 1 foram criados itens e os instrumentos foram analisados por experts e leigos. Na etapa 2, os testes foram aplicados em 15 pacientes com esquizofrenia e 15 controles pareados. Todos foram capazes de compreender e responder aos instrumentos. Na etapa 3, participaram 141 pacientes com esquizofrenia e 119 controles saudáveis com idades entre 18 e 60 anos, avaliados em MT, velocidade de processamento (VP) e funcionalidade. Resultados: Os resultados revelaram bons índices de consistência interna para ambas as medidas desenvolvidas, tanto para a amostra total como para cada grupo separadamente,

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Factor structure of the Positive and Negative Syndrome Scale (PANSS) in Brazil: convergent validation of the Brazilian version

Cited by 49 publications

References 12 publications

Polygenic risk score analyses of symptoms and treatment response in an antipsychotic-naive first episode of psychosis cohort

Polygenic risk score analyses of symptoms and treatment response in an antipsychotic-naive first episode of psychosis cohort

ACE I/D genotype-related increase in ACE plasma activity is a better predictor for schizophrenia diagnosis than the genotype alone

Investigation of cognition in schizophrenia: psychometric properties of instruments for assessing working memory updating

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