Factor V Leiden and G20210A prothrombin mutations are risk factors for very early recurrent miscarriage

Reznikoff-Etiévant, M.F.; Cayol, V.; Carbonne, Bruno; Robert, Annie; Coulet, Florence; Milliez, Jacques

doi:10.1111/j.1471-0528.2001.00298.x

Cited by 50 publications

(51 citation statements)

References 25 publications

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“…Indeed, a difference in FVL carriage between both groups was also reported in several studies [20,36,37]. The investigation of Roque et al [20] reported a reverse association between FVL carriage and embryonic losses (OR 0.23; 95% CI 0.07-0.77) and no association with RPL at postembryonic stage (OR 1.07; 95% CI 0.46-2.5).…”

Section: Factor V Leiden Carriage In Patients With Miscarriagementioning

confidence: 68%

Association of inherited thrombophilia with embryonic and postembryonic recurrent pregnancy loss

Ivanov¹,

Komsa-Penkova²,

Konova

et al. 2009

Blood Coagulation &Amp; Fibrinolysis

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To investigate the impact of maternal-inherited thrombophilia: effects of factor V Leiden (FVL) and prothrombin gene mutation (FII 20210G>A) on the development of recurrent pregnancy loss in embryonic and postembryonic periods. A total of 153 patients were analysed for FVL and FII 20210G>A according to placenta gestation: 94 women with embryonic loss prior 10 weeks of gestation and 59 women with postembryonic (early fetal) loss occurring between 10 and 14 weeks of gestation. The control group consisted of 100 healthy women, with at least one uncomplicated full-term pregnancy. FVL prevalence was not significantly associated with pregnancy loss prior to 10 weeks of gestation (9.6%) compared with controls (7%) [odds ratio (OR) 1.41; 95% confidence interval (CI) 0.454-4.416, P > 0.05], but it was much more pronounced in women with postembryonic loss (10-14 weeks of gestation) - 18.6% (OR 3.05; 95% CI 1.010-9.387, P = 0.047). FII 20210G>A was significantly higher in both groups with embryonic (17%) and early fetal losses (16.9%) as compared to controls (3%) (OR 6.63; 95% CI 1.731-29.752, P = 0.003; OR 6.60; 95% CI 1.572-31.856, P = 0.006). FII 20210G>A is significantly associated with an increased risk of early recurrent pregnancy loss throughout the entire first trimester. FVL was significantly higher only in early fetal period after starting of the placentation process, but not associated with embryonic recurrent pregnancy loss. These results suggested that the first trimester should be viewed rather as a heterogeneous interval, with different relation to FVL in the embryonic and postembryonic fetal period. Genetic testing should be applied according to the diverse contribution of thrombophilic markers to embryonic and postembryonic period.

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Section: Factor V Leiden Carriage In Patients With Miscarriagementioning

confidence: 68%

Association of inherited thrombophilia with embryonic and postembryonic recurrent pregnancy loss

Ivanov¹,

Komsa-Penkova²,

Konova

et al. 2009

Blood Coagulation &Amp; Fibrinolysis

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“…Few case-control studies and meta-analysis had shown a high prevalence of FVL in women with RPL [3, 10, 28–31]. A systematic review of the literature found an OR for the association between RPL and FVL of 2.0 (95% CI 1.5–2.7; P < .001) [3].…”

Section: Discussionmentioning

confidence: 99%

Association of Inherited Thrombophilia with Recurrent Pregnancy Loss in Palestinian Women

Abu-Asab

Ayesh²,

Ateeq³

et al. 2011

Obstetrics and Gynecology International

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Objective. This study aimed at analyzing the association between recurrent pregnancy loss (RPL) and factor V G1691A (FVL), prothrombin G20210 (FII); and MTHFR C677T (MTHFR) in Palestinian women. Method. We studied 329 Palestinian women with RPL and/or stillbirth (SB); and compared them to 402 healthy reproductive Palestinian women. Cases and controls were tested for the above mutations. Odds ratio (OR) at confidence interval (CI) of 95% was used as a measure of association between the mutations and RPL. Results. Our statistical analysis showed a slightly increased association, which was not significant between FVL and RPL (OR 1.32, 95% CI 0.90–1.94), and no association between FII (OR 0.84, 95% CI 0.38–1.92), MTHFR (OR 0.58, 95% CI 0.32–1.03), and RPL. Further analysis of RPL subgroups revealed an association between FVL and first-trimester loss (OR 1.33, 95% CI 0.892–1.989), and second-trimester loss (OR 1.13, 95% CI 0.480–2.426), both were not statistically significant. Furthermore, the only statistically significant association was between FVL and SB (OR 2.0, 95% CI 1.05–3.70). Conclusion. Our analysis had failed to find a significant association between FVL, FII, MTHFR; and RPL in either the first or second trimester. FVL was significantly associated with fetal loss if the loss was a stillbirth.

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“…8 In fact, it has been postulated that maternal thrombophilia could be a risk factor for fetal loss because of the production of microthrombosis on placental bed vessels and placental infarctions, which produce a compromise in the fetomaternal circulatory system, that results in low placental perfusion and eventually in fetal loss. 9,10 …”

Section: Discussionmentioning

confidence: 99%

A Duplex PCR-RFLP Assay for Simultaneous Detection of FV Leiden and Prothrombin G20210A Mutations in Women with Recurrent Miscarriage

Frikha

Abdelmoula

Rebaï

2012

Journal of Experimental & Clinical Medicine

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Factor V Leiden and G20210A prothrombin mutations are risk factors for very early recurrent miscarriage

Cited by 50 publications

References 25 publications

Association of inherited thrombophilia with embryonic and postembryonic recurrent pregnancy loss

Association of inherited thrombophilia with embryonic and postembryonic recurrent pregnancy loss

Association of Inherited Thrombophilia with Recurrent Pregnancy Loss in Palestinian Women

A Duplex PCR-RFLP Assay for Simultaneous Detection of FV Leiden and Prothrombin G20210A Mutations in Women with Recurrent Miscarriage

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