Factor VII-activating protease in patients with acute deep venous thrombosis

Factor VII activating protease (FSAP) regulates the expression of inflammatory genes in vascular smooth muscle and endothelial cells

“…Furthermore low FSAP antigen level was associated with recanalization in stroke patients after tPA treatment 71 . FSAP activity was also found to be increased in acute coronary syndrome patients 72 and in patients with deep venous thrombosis 73 . Taken together, these studies show that FSAP is activated in various cardiovascular diseases and it appears that low proteolytic activity of FSAP is related to increased disease risk.…”

Circulating Factor VII Activating Protease (FSAP) Is Associated With Clinical Outcome in Acute Coronary Syndrome

“…18 Recently, the measurement of circulating FSAP antigen and activity demonstrated a modest association between elevated FSAP concentration and venous thromboembolism. 19 We have shown that the concentrations of circulating FSAP in pregnancy and in women using oral contraceptives are increased, indicating that hormonal status critically influences FSAP expression. 20 Furthermore, SNPs in the FSAP gene are also linked to a higher incidence of venous thrombosis in the elderly.…”

Nicotine Modulation of Factor VII Activating Protease (FSAP) Expression in Human Monocytes

“…Numerous studies have attempted to find a link between the pathogenesis of thromboembolic disease and FSAP 17,18) . We hypothesize that the expression of FSAP in monocytes and their activation status in atherosclerosis and cardiovascular events are closely related to each other 13,16) .…”

“…MI-SNP was found to be an independent risk factor for the development of late complications of carotid stenosis 16) , may also be related to the occurrence of venous thromboembolism 17,18) and represents a general cardiovascular risk factor 19) . Recently, measurements of circulating FSAP antigen and activity demonstrated a modest association between elevated FSAP and venous thromboembolism 18) . We and others have shown that the levels of circulating FSAP during pregnancy and in women using OC were increased, indicating that the hormonal status criti- …”