Factor X Deficiency Presenting with Bilateral Chronic Subdural Hematoma

Şentürk, Senem; Güzel, Ebru; Bayrak, Aylin Hasanefendioğlu; Bükte, Yaşar; Güzel, Aslan

doi:10.1159/000315004

Cited by 14 publications

(10 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…80 Multiple fractures of differing ages (especially posterior rib fractures in infants with subdural hematoma) or inconsistencies between the reported mechanism and the pattern or extent of injuries suggest nonaccidental trauma, especially when there is a delay in seeking medical attention. 81 Conversely, consideration should be given to RBDs in children from consanguineous parents or with a personal or family history of bleeding, particularly in the absence of other features suggesting nonaccidental trauma. Recommendations for consideration of various bleeding disorders, including RBDs, in the setting of possible nonaccidental trauma were recently summarized in a technical report from the American Academy of Pediatrics.…”

Section: State-of-the-art Review Articlementioning

confidence: 99%

Rare Bleeding Disorders in Children: Identification and Primary Care Management

Acharya

2013

Pediatrics

View full text Add to dashboard Cite

Bleeding symptoms are common in healthy children but occasionally may indicate an underlying congenital or acquired bleeding diathesis. The rare bleeding disorders (RBDs) comprise inherited deficiencies of coagulation factors I (congenital fibrinogen deficiencies), II, V, VII, X, XI, and XIII and combined factor deficiencies, most notably of factors V and VIII and of vitamin K-dependent factors. These disorders often manifest during childhood and may present with recurrent or even serious or life-threatening bleeding episodes, particularly during the neonatal period. Accordingly, primary care and other nonhematologist pediatric providers should be familiar with the clinical presentation and initial evaluation of these rare disorders. Bleeding manifestations generally vary within the same RBD and may be indistinguishable from 1 RBD to another or from other more common bleeding disorders. Serious bleeding events such as intracranial hemorrhage may be heralded by less serious bleeding symptoms. The results of initial coagulation studies, especially prothrombin time and activated partial thromboplastin time, are often helpful in narrowing down the potential factor deficiency, with factor XIII deficiency being an exception. Consultation with a hematologist is advised to facilitate accurate diagnosis and to ensure proper management and follow-up. The approach to bleeding episodes and invasive procedures is individualized and depends on the severity, frequency, and, in the case of procedures, likelihood of bleeding. Prophylaxis may be appropriate in children with recurrent serious bleeding and specifically after life-threatening bleeding episodes. When available, specific purified plasma-derived or recombinant factor concentrates, rather than fresh frozen plasma or cryoprecipitate, are the treatment of choice. Pediatrics 2013;132:882-892

show abstract

Section: State-of-the-art Review Articlementioning

confidence: 99%

Rare Bleeding Disorders in Children: Identification and Primary Care Management

Acharya

2013

Pediatrics

View full text Add to dashboard Cite

show abstract

“…Chronic subdural hematomas (CSHs) are generally regarded to be consequences of head trauma 14 51) . The most commonly accepted pathophysiological explanation of CSH is that mild head trauma leads to tearing of bridging veins with subsequent bleeding, thus creating the hematoma 7) .…”

Section: Introductionmentioning

confidence: 99%

“…However, a history of trauma is absent in about 30–50% of the cases, especially after the age of 65 years 1 12 19 52) . Besides trauma, there were numerous risk factors such as alcohol abuse, seizures, cerebrospinal fluid shunts, and coagulopathies including therapeutic anticoagulant 14 51) .…”

Section: Introductionmentioning

confidence: 99%

Chronic Subdural Hematoma in the Aged, Trauma or Degeneration?

Lee

2016

J Korean Neurosurg Soc

View full text Add to dashboard Cite

Chronic subdural hematomas (CSHs) are generally regarded to be a traumatic lesion. It was regarded as a stroke in 17th century, an inflammatory disease in 19th century. From 20th century, it became a traumatic lesion. CSH frequently occur after a trauma, however, it cannot occur when there is no enough subdural space even after a severe head injury. CSH may occur without trauma, when there is sufficient subdural space. The author tried to investigate trends in the causation of CSH. By a review of literature, the author suggested a different view on the causation of CSH. CSH usually originated from either a subdural hygroma or an acute subdural hematoma. Development of CSH starts from the separation of the dural border cell (DBC) layer, which induces proliferation of DBCs with production of neomembrane. Capillaries will follow along the neomembrane. Hemorrhage would occur into the subdural fluid either by tearing of bridge veins or repeated microhemorrhage from the neomembrane. That is the mechanism of hematoma enlargement. Trauma or bleeding tendency may precipitate development of CSH, however, it cannot lead CSH, if there is no sufficient subdural space. The key determinant for development of CSH is a sufficient subdural space, in other words, brain atrophy. The most common and universal cause of brain atrophy is the aging. Modifying Virchow's description, CSH is sometimes traumatic, but most often caused by degeneration of the brain. Now, it is reasonable that degeneration of brain might play pivotal role in development of CSH in the aged persons.

show abstract

“…The heterogeneity of outcome measures in published studies, including assessment tools, follow-up periods and age at ICH makes comparisons difficult; the incidence, risk and functional outcomes of ICH in children with IBD remain unclear [3,4,7,8,11,14,[18][19][20]. The longterm outcomes of patients with IBD who have sustained an ICH therefore remain largely unknown [21][22][23][24][25][26][27][28][29]. The purpose of this service evaluation was to assess the incidence, risk, clinical and functional longterm outcomes of children with IBD, treated at one haemophilia center following ICH, in order to identify ways of improving care for patients.…”

Section: Introductionmentioning

confidence: 99%