Factor XI deficiency in Indian Bos taurus, Bos indicus, Bos taurus x Bos indicus crossbreds and Bubalus bubalis

Patel, Rajesh K; Soni, Kalpesh J.; Chauhan, Jenabhai B.; Singh, Krishna M.; Rao, K. R. S. Sambasiva

doi:10.1590/s1415-47572007000400013

Cited by 10 publications

(8 citation statements)

References 9 publications

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“…In previous studies (Akyüz & Ertuğrul 2006;2008), BLAD and DUMPS alleles were not found in Turkish native cattle breeds. Similarly, BLAD, DUMPS, CVM and BC carriers were not found in Gir cattle in Brazil (Riberio et al 2000), in Polish dairy cattle in Poland (Kaminski et al 2005), in Brown Swiss bulls in Iran (Norouzy et al 2005), in Charolais, Limousine, Beef Simmental, Blonde d'Aquitaine, Belgian Blue, Aberdeen-Angus and Hereford cattle breeds in Czech Republic (Citek et al 2006) and in Jersey cattle, Indian cattle (Bos indicus) breeds, B. taurus x B. indicus crossbreds and the river buffalo (Bubalus bubalis) cattle in India (Patel et al 2007). All these reports and our findings supported the idea that these genetic disorders are specific to only Holstein cattle worldwide.…”

Section: Resultsmentioning

confidence: 99%

Monitoring of BLAD, DUMPS, CVM, BC and FXID in Turkish native cattle breeds

Meydan¹

2012

Tarım Bilimleri Dergisi

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In this study, Turkish native cattle breeds were monitored with respect to the genetic disorders defined as bovine leukocyte adhesion deficiency (BLAD), deficiency of uridine monophosphate synthase (DUMPS), complex vertebral malformation (CVM), bovine citrullinaemia (BC) and factor XI deficiency (FXID). All these are autosomal recessive hereditary disorders causing serious economic losses in dairy cattle breeding throughout the world. In order to determine the presence or the absence of BLAD, DUMPS, CVM, BC and FXID genotypes in native cattle breeds, 200 heads of Anatolian Black, 100 heads of East Anatolian Red, 100 heads of Turkish Grey, 50 heads of Anatolian Southern Yellow, 50 heads of South Anatolian Red and 9 heads of Zavot breed (totally 509 heads) were sampled. Genomic DNA was obtained from blood and the amplicons were obtained by using PCR. PCR products were digested with TaqI, AvaI, EcoT22I and AvaII restriction enzymes for BLAD, DUMPS, CVM, and BC, respectively. Digested products of BLAD, DUMPS CVM and BC were analyzed by agarose gel electrophoresis. PCR products of FXID were analyzed by only agarose gel electrophoresis stained with ethidium bromide. The results demonstrated that no animals examined were the carrier of these genetic disorders. Thus, it can be concluded that mutant alleles of BLAD, DUMPS, CVM, BC and FXID are absent in Turkish native cattle breeds.

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Section: Resultsmentioning

confidence: 99%

Monitoring of BLAD, DUMPS, CVM, BC and FXID in Turkish native cattle breeds

Meydan¹

2012

Tarım Bilimleri Dergisi

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“…This insertion, composed of an imperfect poly-adenine tract followed duplicated region of the normal coding sequence, introduced a premature stop codon (TAA), which impaired the synthesis of functional protein (Marron et al, 2004). Patel et al (2007) found that carrier individual exhibited two fragments with DNA length 247 bp and 324 bp due to the insertion of 77 base pairs insertion within exon 12 of the FXI gene. In this study, we did not find any cattle carrying this genetic defect.…”

Section: Detection Of Mutation Of Factor XI Deficiency (Fxid)mentioning

confidence: 99%

“…These carriers were identified as heterozygous cows and were healthy clinically (Gurgul et al, 2009). Investigation of FXID syndrom in 1001 heads of Indian dairy cattle showed that two holstein bulls detected as heterozygous for FXID, with carrier frequency of 0.6% (Patel et al, 2007). The carriers frequency of the FXID also detected in Turkey, USA, Republic Czech, Iran, Japan with carrier frequency of 1.80%, 1.20%, 0.36%, 2.91% and 2.50% repectively (Meydan et al, 2010;Marron et al, 2004;Čítek et al, 2008;Gurgul et al, 2009;Ghanem et al, 2005).…”

Section: Detection Of Mutation Of Factor XI Deficiency (Fxid)mentioning

confidence: 99%

“…FXI deficiency was not detected in Iranian buffalo (Bagheri et al 2012), Bos indicus, Crossbred of Friesian Holstein and Bos indicus, Jersey, Crossbred of Jersey and Bos indicus, Bubalus buBalis (Patel et al, 2007), Khuzestan native cow and Iranian Holstein cattle (Eyvandi et al, 2011). Similar finding in Bali cattle in Indonesia that there was no detected carriers of FXID in Indonesian Bali cattle breeding centre in this study.…”

Section: Detection Of Mutation Of Factor XI Deficiency (Fxid)mentioning

confidence: 99%

“…FXID in cattle was first discovered in Holstein cattle in Ohio (Kociba et al, 1969) and then spreaded to other countries because of the application of artificial insemination and semen trading. Deficiency of FXI in dairy cattle occurs because there is a mutation in FXI gene exon 12 in chromosome 27 with insertion of 76 nucleotide base (Ghanem et al, 2008;Marron et al, 2004) or 77 nucleotide base (Patel et al, 2007). The other case of FXID in Japanese Black cattle occured because there was an insertion of 15 nucleotide base in FXI gene exon 9 (Kunieda et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Detection of Factor XI Deficiency (FXID) and Complex Vertebral Malformation (CVM) in Bali Cattle

Siswanti

Sumantri

Jakaria

2014

Med Pet

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Factor XI Deficiency (FXID) is caused by imperfect insertion of poly adenine which is resulted in introduction of premature stop codon in FXI gene. Substitution of guanine into thymine in SLC35A3 gene caused Complex Vertebral Malformation (CVM). The research was aimed to detect the presence or absence of a genetic defect mainly CVM using SLC35A3 gene and FXID using FXI gene in Indonesian Bali cattle. The presence of this genetic defect may have a significant economic impact on the breeding program. The research of genetic defect was done mostly in dairy cattle, but there was no report for screening of genetic defect in Bali cattle. In this study, 303 fresh blood samples and 22 semen samples which were collected from Indonesian Bali cattle breeding center (BPTU HMT Denpasar, BPT HMT Serading West Nusa Tenggara and district Barru South Sulawesi) and artificial insemination centre (BBIB Singosari and BIBD Baturiti) were used for screening of FXID and CVM. The amplicons of FXI gene were obtained by using PCR and that for SLC35A3 gene were obtained by using PCR-RFLP method with PstI restriction enzyme. These PCR products were analyzed by using 2% agarose gels electrophoresis. All genotypes were confirmed by DNA sequencing to determine an allele mutant. The allele mutant was not found in all of the samples. The result of this study showed that CVM and FXID were not detected in Bali cattle from Indonesian Bali cattle breeding and artificial insemination centres.

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Novel identification of Factor XI deficiency in Indian Sahiwal (Bos indicus) cattle

et al. 2016

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Factor-XI deficiency (FXID) is inherited as autosomal lethal recessive disorder of carrier Holstein-Friesian bulls. A 76 base pair segment insertion into exon 12 in Factor-XI gene causes FXID in cattle. Keeping this in view the present study was conducted to screen breeding bulls of both indigenous and exotic breeds for mutation in Factor-XI gene and to find out the frequency of FXID carrier animals in breeding bulls. A total of 120 bulls of different age group maintained at Frozen Semen Bull Station, India were randomly selected from different cattle breeds to screen presence of FXID syndrome in breeding sires. Genomic DNA was isolated from blood of the selected bulls. PCR parameters were standardized to obtain 244 and 320 bp amplicons. The results showed that 2 Sahiwal bulls out of 120 animals were carrier for FXID. Amplicons of the carrier animals were sequenced and annoted, which confirms a 76 bp insertion in the exon 12. Bleeding and clotting time showed considerable discrepancy in the carrier animals as compared to the normal animals. The findings of relative mRNA expression of Factor XI transcript revealed identical tendency in the carrier. The frequency of carrier animals and mutant allele was 2.5 % and 0.025 respectively. This study recommends for screening of breeding at AI bull centers in the country for FXID. The study also stands a merit for identification of FXID carrier in Bos indicus for the first time.

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Factor XI deficiency in Indian Bos taurus, Bos indicus, Bos taurus x Bos indicus crossbreds and Bubalus bubalis

Cited by 10 publications

References 9 publications

Monitoring of BLAD, DUMPS, CVM, BC and FXID in Turkish native cattle breeds

Monitoring of BLAD, DUMPS, CVM, BC and FXID in Turkish native cattle breeds

Detection of Factor XI Deficiency (FXID) and Complex Vertebral Malformation (CVM) in Bali Cattle

Novel identification of Factor XI deficiency in Indian Sahiwal (Bos indicus) cattle

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