Factores asociados a síntomas depresivos en pacientes con enfermedad de Parkinson

Pinto, L.; Alva-Díaz, Carlos; Torres, Luís

doi:10.1016/j.medcli.2017.07.022

Cited by 3 publications

(1 citation statement)

References 4 publications

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“… 26 The prevalence of depression in PD varies widely in different studies (2.7–90%) 3 We collected data for a number of disease and lifestyle features that could be linked to the development of depression in this population. Of the 221 PD patients, 125 (55.6%) presented depression, similar to the rate reported by Pinto et al 27 However, this rate was higher than found in Xinjiang patients (42.2%). 28 A previous study established a correlation between gender and PDD, 29 and showed that PDD prevalence is significantly higher in females (62.4%) compared with males (37.6%).…”

Section: Discussionsupporting

confidence: 83%

Depression and Related Factors in Patients with Parkinson’s Disease at High Altitude

Cao

Xue³

et al. 2021

NDT

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Section: Discussionsupporting

confidence: 83%

Depression and Related Factors in Patients with Parkinson’s Disease at High Altitude

Cao

Xue³

et al. 2021

NDT

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Focus on Depression in Parkinson’s Disease: A Delphi Consensus of Experts in Psychiatry, Neurology, and Geriatrics

Agüera-Ortíz

García-Ramos

Pérez

et al. 2021

Parkinson's Disease

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Major and minor forms of depression are significant contributors to Parkinson’s disease morbidity and caregiver burden, affecting up to 50% of these patients. Nonetheless, symptoms of depression are still underrecognized and undertreated in this context due to scarcity of evidence and, consequently, consistent clinical guideline recommendations. Here, we carried out a prospective, multicentre, 2-round modified Delphi survey with 49 questions about the aetiopathological mechanisms of depression in Parkinson’s disease (10), clinical features and connections with motor and nonmotor symptoms (10), diagnostic criteria (5), and therapeutic options (24). Items were assessed by a panel of 37 experts (neurologists, psychiatrists, and a geriatrist), and consensus was achieved in 81.6% of them. Depressive symptoms, enhanced by multiple patient circumstances, were considered Parkinson’s disease risk factors but not clinical indicators of motor symptom and disease progression. These patients should be systematically screened for depression while ruling out both anhedonia and apathy symptoms as they are not necessarily linked to it. Clinical scales (mainly the Geriatric Depression Scale GDS-15) can help establishing the diagnosis of depression, the symptoms of which will require treatment regardless of severity. Efficacious and well-tolerated pharmacological options for Parkinson’s comorbid depression were selective serotonin reuptake inhibitors (especially sertraline), dual-action serotonin and norepinephrine reuptake inhibitors (venlafaxine, desvenlafaxine, and duloxetine), multimodal (vortioxetine, bupropion, mirtazapine, and tianeptine), and anti-Parkinsonian dopamine agonists (pramipexole, ropinirole, and rotigotine). Tricyclic antidepressants and combining type B monoamine oxidase inhibitors with serotonergic drugs have serious side effects in these patients and therefore should not be prescribed. Electroconvulsive therapy was indicated for severe and drug-refractory cases. Cognitive behavioural therapy was recommended in cases of mild depression. Results presented here are useful diagnostic and patient management guidance for other physicians and important considerations to improve future drug trial design.

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Factors associated with depression in patients with Parkinson’s disease A multicenter study in Lima, Peru

Custodio

Alva-Díaz

Morán‐Mariños

et al. 2018

Dement. neuropsychol.

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The diagnosis and treatment of depression in patients with Parkinson’s disease (PD) is inadequate, often contributing to a reduced quality of life, rapid disease progression, higher cognitive impairment, and an increased burden of care for family members of patients with PD.Objective:To determine the factors associated with depression in PD and to examine the frequency of depressive symptoms among patients with PD.Methods:This study was an observational, analytical, multicenter study of a cross-sectional cohort, conducted between July 2016 and May 2017. PD patients were recruited from neurology clinics in Lima, Peru. All statistical analyses were performed using descriptive statistics. Bivariate and multivariate logistic regression analyses were calculated using STATA.Results:Out of 124 patients (average age: 68.7 years; 58% males) included in the study 60.5% (75/124) presented with symptoms of depression; only 20% (25/124) received antidepressants. Factors associated with depression in PD included: unemployment, falls, freezing of gait, involuntary movements micrographia, stooped posture, hyposmia, movement disorders in sleep, rapid disease progression, and the use of MAOIs. Furthermore, statistically significant differences were found in disease duration, UPDRS and MMSE scores, Hoehn and Yahr (HY) stage, and length of time taking L-dopa between PD patients with and without depressive symptoms.Conclusion:Factors associated with depressive symptoms in patients with PD were hyposmia, rapid progression of the disease, the use of L-dopa, and use of MAOIs. The frequency of depressive symptoms in patients with PD is high; early diagnosis and prompt treatment are needed to improve their quality of life and the family environment.

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Factores asociados a síntomas depresivos en pacientes con enfermedad de Parkinson

Cited by 3 publications

References 4 publications

Depression and Related Factors in Patients with Parkinson’s Disease at High Altitude

Depression and Related Factors in Patients with Parkinson’s Disease at High Altitude

Focus on Depression in Parkinson’s Disease: A Delphi Consensus of Experts in Psychiatry, Neurology, and Geriatrics

Factors associated with depression in patients with Parkinson’s disease A multicenter study in Lima, Peru

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