Factores asociados al desarrollo de infección urinaria de origen comunitario causada por Escherichia coli resistente a fluoroquinolonas

Seija, Verónica; Fratchez, Victoria; Ventura, Verónica; Pintos, Marcos; González, Mariana

doi:10.4067/s0716-10182014000400004

Cited by 8 publications

(5 citation statements)

References 30 publications

(41 reference statements)

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“…In assessing antibiotic efficacy over the period of the six years of the study, we observed a significant increase in resistance to fluoroquinolones (ciprofloxacin and norfloxacin) over time, which may be due to empirical treatment of urinary infections. This effect was also reported in Uruguay, a country with extensive use of fluoroquinolones as a form of empirical treatment for urinary infections [ 21 ], as well as in another study highlighting the risk factors for urinary tract infections in ambulatory patients exhibiting microbial resistance to fluoroquinolones [ 26 ]. The concern regarding microbiological resistance requires changes enabling preventive measures or the discovery of new therapeutic targets by the scientific community.…”

Section: Discussionsupporting

confidence: 64%

“…Several studies have evaluated the microbicidal activity of the antibiotics used for urinary tract infections, as well as the mechanisms involved in drug resistance [ 6 , 18 , 20 , 21 ]. Such studies demonstrate a major cause for concern regarding the epidemiology of resistance to antibiotics used to treat urinary infections [ 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

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Antibiotic Resistance of Bacteria Involved in Urinary Infections in Brazil: A Cross-Sectional and Retrospective Study

Rodrigues

Miguel

Nogueira

et al. 2016

IJERPH

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Empirical and prolonged antimicrobial treatment of urinary tract infections caused by Escherichia coli is associated with the emergence of bacterial resistance, and not all countries have strict policies against the indiscriminate use of drugs in order to prevent resistance. This cross-sectional and retrospective study (2010–2015) aimed to evaluate the sensitivity and resistance of patient-derived E. coli to different drugs broadly used to treat urinary infections in Brazil: ampicillin + sulbactam, cephalothin, ciprofloxacin, norfloxacin, and nitrofurantoin. We obtained 1654 E. coli samples from ambulatory patients with disease symptoms of the urinary tract from a Brazilian public hospital. While all antibiotics were effective in killing E. coli to a large degree, nitrofurantoin was the most effective, with fewer samples exhibiting antibiotic resistance. We assessed the costs of generic and brand name versions of each antibiotic. Nitrofurantoin, the most effective antibiotic, was the cheapest, followed by the fluoroquinolones (ciprofloxacin and norfloxacin), ampicillin + sulbactam and, lastly, cephalothin. Finally, assessment of antibiotic resistance to fluoroquinolones over the study period and extrapolation of the data led to the conclusion that these antibiotics could no longer be effective against E. coli-based urinary infections in approximately 20 years if their indiscriminate use in empirical treatment continues.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Antibiotic Resistance of Bacteria Involved in Urinary Infections in Brazil: A Cross-Sectional and Retrospective Study

Rodrigues

Miguel

Nogueira

et al. 2016

IJERPH

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“…T his study, in addition to other studies, showed that uti episodes occur more frequently in women (14)(15)(16). Whereas some literature indicates that the average age of the most frequently affected patients is 65 years, other studies report ages from 35 to 40 years (17,18).…”

Section: Discussionsupporting

confidence: 59%

Factores asociados con la presencia de patógenos productores de betalactamasas de espectro extendido en infecciones urinarias en una clínica privada, Lima (Perú)

2020

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Introducción: las infecciones del tracto urinario (ITU) son el segundo motivo más frecuente de atención médica, y la resistencia a los antibióticos entre las enterobacterias gramnegativas ha aumentado de manera importante en todo el mundo, dada la aparición de organismos productores de betalactamasa de espectro extendido (BLEE). Se busca identificar factores asociados a la presencia de ITU por patógeno productor de BLEE. Materiales y métodos: se realizó un estudio trasversal analítico, un análisis de la base de datos de urocultivos de una clínica privada y una evaluación de los factores posiblemente asociados a la presentación de ITU por el microorganismo BLEE, como el sexo, la edad, el número de hospitalizaciones e ITU previas. Resultados: se estudiaron 1405 urocultivos positivos y se encontró que el 85.48 % fueron de sexo femenino. La edad media de la población fue de 39.98 ± 24.51 años, el 24.13 % de edad mayor a 60 años, y el 55.56 % habían sido atendidos ambulatoriamente. El 49.18 % de los cultivos fue positivo para ITU BLEE, de los cuales el 96,58 % no habían presentado una ITU previa. Se encontró que existe una asociación estadísticamente significativa (0,007; p ≤ 0,05) entre el sexo y el desarrollo de ITU por microorganismo productor de BLEE. El masculino es el de mayor asociación (OR 1,224; IC95 %: 1,035-1,448). También se encontró una asociación con la edad, el número de hospitalizaciones previas y haber estado en UCI. No se encontró ninguna asociación entre la presencia de ITU previas. Conclusiones: existe una elevada frecuencia de ITU BLEE, y los factores asociados a dicha infección fueron tener sexo masculino, una edad mayor a 60 años y hospitalizaciones previas.

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“…Here we identified age over 60 years, complicated urinary tract infections, and urinary catheterization as risk factors for infection with ESBL-producing E. coli strains. Other studies have also shown older age (35)(36)(37)(38)(39)(40), urinary catheterization (36,37,39) and complicated urinary tract infections (40) as factors that increase the risk of acquiring a urinary tract infection by multidrug resistant bacteria.…”

Section: Discussionmentioning

confidence: 99%

Multidrug resistance and risk factors associated with community-acquired urinary tract infections caused by Escherichia coli in Venezuela

et al. 2019

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Introduction: The treatment of urinary tract infections has become more challenging due to the increasing frequency of multidrug-resistant Escherichia coli in human populations.Objective: To characterize multidrug-resistant E. coli isolates causing community-acquired urinary tract infections in Cumaná, Venezuela, and associate possible risk factors for infection by extended-spectrum beta-lactamases (ESBL)-producing isolates.Materials and methods: We included all the patients with urinary tract infections attending the urology outpatient consultation and emergency unit in the Hospital de Cumaná, Estado Sucre, Venezuela, from January through June, 2014. blaTEM, blaSHV and blaCTX-M genes detection was carried out by PCR.Results: We found a high prevalence of multidrug-resistant E. coli (25.2%) with 20.4% of the isolates producing ESBL. The ESBL-producing isolates showed a high frequency (66.7%) of simultaneous resistance to trimethoprim-sulphamethoxazole, fluoroquinolones and aminoglycosides compared to non-producing isolates (2.4%). Of the resistant isolates, 65.4% carried the blaTEM gene, 34.6% the blaCTX-M and 23.1% the blaSHV. The blaCTX-M genes detected belonged to the CTX-M-1 and CTX-M-2 groups. Plasmid transfer was demonstrated by in vitro conjugation in 17 of the 26 ESBL-producing isolates. All three genes detected were transferred to the transconjugants. Age over 60 years, complicated urinary tract infections and previous use of a catheter predisposed patients to infection by ESBL-producing E. coli.Conclusions: The high frequency of multidrug-resistant ESBL-producing isolates should alert the regional health authorities to take measures to reduce the risk of outbreaks caused by these types of bacteria in the community.

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Factores asociados al desarrollo de infección urinaria de origen comunitario causada por Escherichia coli resistente a fluoroquinolonas

Cited by 8 publications

References 30 publications

Antibiotic Resistance of Bacteria Involved in Urinary Infections in Brazil: A Cross-Sectional and Retrospective Study

Antibiotic Resistance of Bacteria Involved in Urinary Infections in Brazil: A Cross-Sectional and Retrospective Study

Factores asociados con la presencia de patógenos productores de betalactamasas de espectro extendido en infecciones urinarias en una clínica privada, Lima (Perú)

Multidrug resistance and risk factors associated with community-acquired urinary tract infections caused by Escherichia coli in Venezuela

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