Introduction: Non-Palpable Breast Lesions constitute a difficult health problem for both patients and the doctors who care for them. Objective: Characterize the clinical and therapeutic management of women with non-palpable breast lesions. Method: A descriptive and cross-sectional observational study was carried out. The study universe was made up of 43 patients with non-palpable breasts lesions. The variables age, menarche, menopause, hormonal status, gestational history, conception of first child, lactation, family pathological history, body mass index, lesion location, type of lesion, BIRADS Stage, pathologic diagnosis, type of management and type of surgery were evaluated. Results: The most frequent clinical and epidemiological characteristics were age between 40-49 (39.5%); normal menarche and menopause with (48.8% and 51.2%) respectively; Within the hormonal state, postmenopausal women accounted for 65.1%; as well as the parity of the first child after 35 years of age and nulliparity for 83.7% and 62.8% respectively and the location of the most frequent lesion was in the upper external quadrant for 32.6%. Microcalcifications were the most frequent lesions. Conclusions: Family history of breast cancer, age, menarche, menopause, gestational history and location of the lesions were found. Microcalcifications were common, with a predominance of BIRADS IV lesions. Although benign ones predominate, a notable group were malignant, requiring surgical treatment, with only one treated conservatively.