Factores de riesgo metabólico en urolitiasis cálcica según el sexo y edad de los pacientes

Martín, Juan Alberto Lancina; Garcia, Joana Coeli Ribeiro; Castro, Serafín Novás; Gómez, I. Rodríguez; Rosado, E. Fernández; Castelo, L. Álvarez; Díez, A. Blanco; Martín, M. González

doi:10.1016/s0210-4806(02)72742-3

Cited by 15 publications

(7 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Men experience more stones and produce more urinary phosphate, calcium, uric acid, magnesium, oxalate and creatinine and less citrate than women of the same age [39], [41], [42]. Our findings indicate that males and females also have differences in IIV for citrate and phosphorus with changing IIV for citrate by age and sex age, either as a function of dietary differences or from endogenous effects associated with sex.…”

Section: Discussionmentioning

confidence: 65%

Effects of Sex on Intra-Individual Variance in Urinary Solutes in Stone-Formers Collected from a Single Clinical Laboratory

2013

View full text Add to dashboard Cite

Background/AimsOur work in a rodent model of urinary calcium suggests genetic and gender effects on increased residual variability in urine chemistries. Based on these findings, we hypothesized that sex would similarly be associated with residual variation in human urine solutes. Sex-related effects on residuals might affect the establishment of physiological baselines and error in medical assays.MethodsWe tested the effects of sex on residual variation in urine chemistry by estimating coefficients of variation (CV) for urinary solutes in paired sequential 24-h urines (≤72 hour interval) in 6,758 females and 9,024 males aged 16–80 submitted to a clinical laboratory.ResultsFemales had higher CVs than males for urinary phosphorus overall at the False Discovery Rate (P<0.01). There was no effect of sex on CV for calcium (P>0.3). Males had higher CVs for citrate (P<0.01) from ages 16–45 and females higher CVs for citrate (P<0.01) from ages 56–80, suggesting effects of an extant oestral cycle on residual variance.ConclusionsOur findings indicate the effects of sex on residual variance of the excretion of urinary solutes including phosphorus and citrate; differences in CV by sex might reflect dietary lability, differences in the fidelity of reporting or genetic differentiation in renal solute consistency. Such an effect could complicate medical analysis by the addition of random error to phenotypic assays. Renal analysis might require explicit incorporation of heterogeneity among factorial effects, and for sex in particular.

show abstract

Section: Discussionmentioning

confidence: 65%

Effects of Sex on Intra-Individual Variance in Urinary Solutes in Stone-Formers Collected from a Single Clinical Laboratory

2013

View full text Add to dashboard Cite

show abstract

“…In this sense, there are several articles about metabolic alterations in patients with nephrolithiasis and assessment of these according to age and sex. Lancina Martin et al [1] published in 2002 that women with calcium stone disease have hypercalciuria as the most frequent metabolic disorder and absorptive disorder as the most common of these, although resorptive hypercalciuria was more prevalent in women than in men with a statistically significant difference. Those authors described a calcium/creatinine ratio in this group of women of 0.17, which is similar to the value we obtained in our group of women with recurrent calcium nephrolithiasis, both fasting and 24-hour (0.14 and 0.21, respectively).…”

Section: Discussionmentioning

confidence: 99%

“…Nowadays, bone densitometry is considered the gold standard for the diagnosis of osteoporosis [1,16], but recent research has highlighted that measuring bone formation and resorption markers could improve diagnosis. Several lines of research have shown that bone markers are increased even in the premenopausal period without evident changes in bone mineral density loss as shown by densitometry [5].…”

Section: Discussionmentioning

confidence: 99%

“…There is a male predominance of incidence (ratio of 1.5-2 for men compared with women), and the first event occurs later in women. Likewise, recurrent episodes are more frequent in men than in women, with a ratio 1.5-1 (for men compared with women) [1]. Metabolic imbalances are thought to be more common in men with recurrent nephrolithiasis in terms of hypercalciuria and hypocitraturia [2,3], and an understanding of stone formation is important for knowing the diseases responsible for recurrent calcium nephrolithiasis [4].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bone and Metabolic Markers in Women With Recurrent Calcium Stones

2013

View full text Add to dashboard Cite

PurposeThe target of our work was to study several biochemical parameters in phospho-calcic and bone metabolism in blood and urine and the bone mineral density of women with recurrent calcium nephrolithiasis.Materials and MethodsWe conducted a cross-sectional study with a control group of 85 women divided into 3 groups: group 1 consisted of 25 women without a history of nephrolithiasis, group 2 consisted of 35 women with only one episode of calcium nephrolithiasis, and group 3 consisted of 25 women with a history of recurrent calcium nephrolithiasis. Blood and urine biochemical study was performed, including markers related to lithiasis, and a bone mineral density study was done by use of bone densitometry.ResultsPatients in group 3 showed statistically significantly elevated calciuria (15.4 mg/dL), fasting calcium/creatinine ratio (0.14), and 24-hour calcium/creatinine ratio (0.21) compared with groups 1 and 2. Moreover, this group of women with recurrent calcium nephrolithiasis had significantly elevated values of beta-crosslaps, a bone resorption marker, compared with groups 1 and 2 (p=0.000) and showed more bone mineral density loss than did these groups.ConclusionsRecurrent calcium nephrolithiasis in women has a significant association with bone mineral density loss and with values of calciuria, both fasting and 24-hour.

show abstract

“…Urolithiasis is the first most common urological disease affecting both males and females; it is predominant among males in a proportion of approximately 2:1 [1,2].…”

Section: Introductionmentioning

confidence: 99%

Biochemical Compositions of Urolithiasis among Yemeni Patients

Aithah¹

2023

TUJNAS

View full text Add to dashboard Cite

Objectives: Since the chemical composition of calculi is very important for the purpose of determining both the origin and etiology, the present study was therefore done to perform the chemical analysis of stones to know the pattern of biochemical composition of stones among Yemeni patients. Methodology: Kidney stones were sent to Central Laboratory; in Sana’a, the capital of the Republic of Yemen for chemical analysis. The stones were washed in distilled water grinded and powdered in a mortar and were analyzed by samiquantitative method. The poweredred stones and standard both were analyzed for uric acid, cystine, oxalate, carbonates, phosphates; ammonia, calcium and magnesium contents. Data extracted from the records included age, sex, occupation and place of residence. The software SPSS 13.0 for Windows was used for data entry and analysis. Chi-Square test was used to compare between different results. P values < 0.05 were considered significant. Results: One hundred eight (108) stones were analyzed chemically during the period from 1st January, 2010 to 30th October 2011. All patients were Yemeni from different part of the country working in the military and their families were included in the study. The mean age of the participants included in the analysis was 29.65 ± 11.36. There were 94 (87%) stones belonged to males, while 14 (13%) stones to female. The male to female ratio was 6:1.Out of a total of 108 stones, 60 stones (55.6%) were calcium oxalate, 30(27.8%) were uric acid mixed with calcium oxalate and 5 (4.6%) stones were phosphate mixed with calcium oxalate. The association between gender and biochemical composition of renal stones were positive and statistically significant (χ = 19.072, P s= 0.025).

show abstract

Factores de riesgo metabólico en urolitiasis cálcica según el sexo y edad de los pacientes

Cited by 15 publications

References 17 publications

Effects of Sex on Intra-Individual Variance in Urinary Solutes in Stone-Formers Collected from a Single Clinical Laboratory

Effects of Sex on Intra-Individual Variance in Urinary Solutes in Stone-Formers Collected from a Single Clinical Laboratory

Bone and Metabolic Markers in Women With Recurrent Calcium Stones

Biochemical Compositions of Urolithiasis among Yemeni Patients

Contact Info

Product

Resources

About