Factores de riesgo para complicaciones graves de COVID-19, comparando tres olas epidemiológicas. Un enfoque desde la atención primaria en México

Assessing the impact of the Gamma variant on COVID-19 patient admissions in a southern Brazilian tertiary hospital—A comparison of dual pandemic phases

“…severe disease (15 days; IQR 9-26) compared to those with moderate disease (5 days; IQR 3-9), p<0.001. Similar findings were observed for the length of ICU stay (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) in severe disease versus 4 days [IQR 2-6] in moderate disease; p<0.001). Higher values of ferritin (median 1549ng/mL [IQR 682.5-2885.75ng/ml]; p<0.001) and c-reactive protein (CRP) (median 12.2mg/dL [IQR 6.46-16ng/ml]; p<0.001) were also associated with severe disease.…”

“…Subsequent studies showed that advanced age and male sex were associated with more severe disease and the potential need for mechanical ventilation and admission to critical units, regardless of preexisting comorbidities [17]. A Mexican study showed that being above the age over 65 was associated with a higher risk of hospitalization, especially when obesity was present, [18] and a study from India showed a significant association between advanced age and the risk of progressing to severe and critical disease [19]. Immunosenescence is responsible for changes in the innate and adaptive immune response, and advanced age is naturally related to poor immune responses.…”

“…A Mexican study compared the first three waves of the pandemic and showed an increase in the risk of hospitalization among young patients throughout the waves, with a significant higher OR in the age group of 25-29 years in the third wave compared to the age group above 45 years in the first wave [2,20]. The median age of hospital admissions was reduced by nearly ten years, and there was a 7% increase in hospital admissions among individuals aged 0 to 19 [18,20]. Some hypotheses, such as previous infection immunity and vaccination coverage, may explain this finding.…”

Assessing the impact of the Gamma variant on COVID-19 Patient admissions in a Southern Brazilian tertiary hospital - A comparison of dual pandemic phases

“…[2,20] The median age of hospital admissions was reduced by nearly ten years, and there was a 7% increase in hospital admissions among individuals aged 0 to 19. [18,20] Some hypotheses, such as previous infection immunity and vaccination coverage, may explain this finding. In Curitiba, the COVID-19 vaccination began on January, 2021, for older adults, reaching the age group of 65 years in mid-April 2021.…”

“…[9,16] Subsequent studies showed that advanced age and male sex were associated with more severe disease and the potential need for mechanical ventilation and admission to critical units, regardless of pre-existing comorbidities. [17] A Mexican study showed that being above the age over 65 was associated with a higher risk of hospitalization, especially when obesity was present, [18] and a study from India showed a significant association between advanced age and the risk of progressing to severe and critical disease. [19] Immunosenescence is responsible for changes in the innate and adaptive immune response, and advanced age is naturally related to poor immune responses.…”