The increase in the survival of preterm newborns has also meant an increase in morbidity and neurodevelopmental disorders, which can manifest themselves, to different degrees, as cognitive, behavioral, academic, emotional, psychosocial and adaptive function problems. There are multiple risk factors related to impaired neurodevelopment, among the main ones: low Apgar score, prolonged hospitalization, perinatal hypoxia, weight less than 1500 grams, moderate prematurity and congenital defects. Measures or interventions that directly or indirectly improve neurodevelopmental outcomes have been described, such as advances in mechanical ventilation including non-invasive techniques, antenatal administration of corticosteroids and magnesium sulfate, as well as the use of pulmonary surfactant, and avoiding early corticosteroid therapy in the newborn. The role of the pediatrician is extremely important in the evaluation of the patient at risk of presenting neurodevelopmental alterations, as well as in the follow-up, it is necessary to use standardized tools that allow a correct evaluation and early intervention.