Factores de riesgo vascular y enfermedad de Alzheimer

X-ray imaging of differential vascular density in MMP-9−/−, PAR-1−/+, hyperhomocysteinemic (CBS−/+) and diabetic (Ins2−/+) mice

“…Although it is known that Hcy caused cerebral vascular dementia (Nilsson et al ., 2008; Davis et al ., 2009; Kivipelto et al ., 2009; Regalado Dona et al, 2009), it was unclear whether it led to decrease in vascular density and vasospasm. We demonstrated the HHcy caused decrease in vascular density in the brain (Figure 2).…”

“…The elevated levels of homocysteine (Hcy) known as hyperhomocysteinemia (HHcy) cause vascular dementia, cerebral vascular complication and retardation (Nilsson et al ., 2008; Sala et al ., 2008; Davis et al ., 2009; Kivipelto et al ., 2009; Regalado Dona et al, 2009). Hyperhomocysteinemia causes constrictive vascular remodelling by increased collagen deposition in the vessel wall (Guo et al ., 2008).…”

Influencia del patrón circadiano de la presión arterial en la mortalidad de una cohorte de nonagenarios. Valoración a los tres años de seguimiento

“…Se hallaron resultados similares (MEC bajo predijo mortalidad) los 24 meses de seguimiento del total de la cohorte Nonasatfeliul 6 . Además, la hipertensión debe ser considerada como un factor de riesgo para el deterioro cognitivo aunque los resultados son discordantes 24 .…”

Síntesis empírica de meta-análisis, técnicas de optimización multi-objetivo y minería de datos aplicadas al diagnóstico de la Enfermedad de Alzheimer

“…There are several strong arguments for studying these variables in-depth. On the one hand, the association of cardiovascular risk factors may be due to shared risk factors between vascular diseases -such as stroke, hypertension, or cholesterol -and AD, but there could also be a direct causal association, since heart disease causes hypoperfusion and micro emboli, which are implicated in the etiology of AD (367). The coexistence of anatomopathological lesions typical of AD and vascular lesions has been demonstrated by autopsy (368).…”