Factores predictivos de las interacciones farmacológicas clínicamente significativas en los pacientes tratados con regímenes basados en inhibidores de proteasa, inhibidores de transcriptasa inversa no nucleósidos y raltegravir

Cervero, Miguel; Torres, Rafael; Jusdado, Juan José; Pastor, Susana; Agud, J.L.

doi:10.1016/j.medcli.2016.01.016

Cited by 5 publications

(1 citation statement)

References 20 publications

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“…The total percentage of clinically relevant interactions found in this population was 18.7%, a lower rate than reported recently by Cervero et al 26 in Spain, who found that 29.11% of a group of 142 participants had at least one PI. These differences can be mainly due to differences in the prescribed ARV regimes between these two populations.…”

Section: Discussioncontrasting

confidence: 66%

Analysis of self-reported adverse reactions to efavirenz and drug interactions in a population with HIV in Mexico

Martínez-Salazar

Oaxaca-Navarro²,

Leija

et al. 2017

Eur J Hosp Pharm

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ObjectiveTo analyse the most frequent self-reported adverse reactions (ARs), the durability and the causes of antiretrovirals (ARVs) regimens change, concomitant treatments and drug interactions related to the use of ARVs in a group of people living with HIV in Cuernavaca, Morelos, Mexico.Materials and methodsCross-sectional study conducted in a clinic specialising in HIV ‘CAPASITS-Cuernavaca’ in Mexico from February to June 2015. People who wanted to participate were given a questionnaire on demographic characteristics, adherence, concomitant treatments and ARs. To understand the clinical variables, the clinical records were reviewed. Quantitative variables were compared using Student’s t-test for normal data and the Mann-Whitney U test for non-normal data. For comparisons between categorical variables, the χ2 test was used. All tests used a significance level of 0.05.ResultsA total of 96 people participated, and 218 ARs (mean= 2.3±1.9) were found. The most frequently encountered ARs were dizziness (53.1%), insomnia (21.9%) and lucid dreams (17.7%). Twenty-three people (24%) were polymedicated, and 18 potential interactions were detected in 12 people.ConclusionsThe results suggest that a thorough analysis of the possible drug interactions should be performed for polymedicated people on ARV treatment and that a protocol should be designed for the monitoring and management of AR to ensure a good adherence to ARV treatment.

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Section: Discussioncontrasting

confidence: 66%