2015
DOI: 10.1016/j.ad.2015.01.006
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Factores predictores de respuesta y revisión de la toxicidad cutánea de cetuximab y panitumumab en 116 pacientes

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Cited by 17 publications
(7 citation statements)
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“…More dermatologic AEs were reported in the triple- than the dual-combination therapy group. It should be noted, however, that the incidence of dermatologic AEs was much lower than has been previously reported for single-agent use of BRAF inhibitors (67% of 18 patients had hand-foot skin reaction)(30) or EGFR inhibitors (82% of 116 patients had papulopustular rash)(31), consistent with an opposing effect of encorafenib and cetuximab on ERK signaling in skin. Paradoxical activation of ERK signaling in BRAF wild-type tissues with BRAF inhibitors has been previously reported.…”
Section: Discussionsupporting
confidence: 56%
“…More dermatologic AEs were reported in the triple- than the dual-combination therapy group. It should be noted, however, that the incidence of dermatologic AEs was much lower than has been previously reported for single-agent use of BRAF inhibitors (67% of 18 patients had hand-foot skin reaction)(30) or EGFR inhibitors (82% of 116 patients had papulopustular rash)(31), consistent with an opposing effect of encorafenib and cetuximab on ERK signaling in skin. Paradoxical activation of ERK signaling in BRAF wild-type tissues with BRAF inhibitors has been previously reported.…”
Section: Discussionsupporting
confidence: 56%
“…57 Patients are cautioned to avoid sunbathing, direct sunlight, hot temperatures, and humidity. 48,58,59,61 Patients should avoid manipulation of skin or hot blow-drying of the hair because these can increase the risk of infection. 39 Although the use of greasy creams such as petroleum jelly is highly effective, the treatment can cause folliculitis owing to its occlusive properties.…”
Section: Reviewmentioning
confidence: 99%
“…Unless properly managed, these can result in dose reductions and discontinuation of treatment, in about 15–25% of patients [68]. The most common (90% of patients with cutaneous toxicity) and clinically most relevant skin toxicity associated with cetuximab is the papulopustular rash, also called acneiform rash [9]. Dermatologic toxicities are rarely life threatening; however, they impair quality of life (QoL) and treatment compliance.…”
Section: Introductionmentioning
confidence: 99%