Factores relacionados a tumores neuroendocrinos gástricos

Soto-Solís, Rodrigo; Romano-Munive, Adriana Fabiola; Anda, K. Santana de; Barreto-Zúñiga, Rafael

doi:10.1016/j.rgmx.2018.03.002

Cited by 5 publications

(2 citation statements)

References 10 publications

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“…Generally, this malignancy can be found anywhere along the gastrointestinal tract and has a poor outcome. They represent a diverse group of neoplasms closely related to the presence of autoimmune atrophic gastritis [ 1 , 2 ]. These tumours represent a therapeutic challenge where endoscopic studies are a fundamental element for their diagnosis [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Detection of Neuroendocrine Tumours by Enteroscopy: A Case Report

Ortega Larrode,

Farrais Villalba,

Guerrero Muñoz

et al. 2023

Medicina

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We present the case of a 62-year-old patient who developed melenas and in whom conventional endoscopic tests could not detect any bleeding lesion. In our case, capsule endoscopy and enteroscopy were the pivotal elements in establishing the diagnosis of a neuroendocrine tumour with an atypical location. As a result, it was possible to surgically remove the lesions at an early stage of the malignancy without metastatic disease and without the need for adjuvant therapy. Our case demonstrates the need for these new techniques in tumours of atypical location and aggressive course. Otherwise, this malignancy may be underdiagnosed until an advanced stage.

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Section: Introductionmentioning

confidence: 99%

Detection of Neuroendocrine Tumours by Enteroscopy: A Case Report

Ortega Larrode,

Farrais Villalba,

Guerrero Muñoz

et al. 2023

Medicina

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“…Independent risk factors for the development of gNEN-1 are identified: age over 59 years, male gender, elevated chromogranin A (CgA) serum levels and histological findings of intestinal metaplasia (Campana et al 2017). The long-term intake of proton pump inhibitors as independent risk factor for gNEN-1 is still under discussion, but new evidence questions this association (Soto-Solis et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Gastric neuroendocrine neoplasias: manifestations and comparative outcomes

Felder

Jann

Arsenić

et al. 2019

Endocrine-Related Cancer

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Although gastric neuroendocrine neoplasias (gNEN) are an orphan disease, their incidence is rising. The heterogeneous clinical course powers the ongoing discussion of the most appropriate classification system and management. Prognostic relevance of proposed classifications was retrospectively analysed in 142 patients from a single tertiary referral centre. Baseline, management and survival data were acquired for statistical analyses. The distribution according to the clinicopathological typification was gNEN-1 (n = 86/60.6%), gNEN-2 (n = 7/4.9%), gNEN-3 (n = 24/16.9%) and gNEN-4 (n = 25/17.6%), while hypergastrinemia-associated gNEN-1 and -2 were all low-grade tumours (NET-G1/2), formerly termed sporadic gNEN-3 could be subdivided into gNEN-3 with grade 1 or 2 and gNEN-4 with grade 3 (NEC-G3). During follow-up 36 patients died (25%). The mean overall survival (OS) of all gNEN was 14.2 years. The OS differed statistically significant across all subgroups with either classification system. According to UICC 2017 TNM classification, OS differed for early and advanced stages, while WHO grading indicated poorer prognosis for NEC-G3. Cox regression analysis confirmed the independent prognostic validity of either classification system for survival. Particularly careful analysis of the clinical course of gNEN-1 (ECLomas, gastric carcinoids) confirmed their mostly benign, but recurrent and extremely slowly progressive behaviour with low risk of metastasis (7%) and an efficient long-term control by repetitive endoscopic procedures. Our study provides evidence for the validity of current classifications focusing on typing, grading and staging. These are crucial tools for risk stratification, especially to differentiate gNEN-1 as well as sporadic gNET and gNEC (gNEN-3 vs -4).

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