1996
DOI: 10.1016/s0936-6555(05)80657-0
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Factors affecting acute skin toxicity in patients having breast irradiation after conservative surgery: A prospective study of treatment practice at the Royal Marsden Hospital

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Cited by 108 publications
(76 citation statements)
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“…Body mass index, correlated to breast size and brassiere size, has also been linked to the risk of acute skin reactions and to late cosmesis [10][11][12]. Not all studies are confirmatory, but the weight of evidence suggests that the association between the size of the breast and the risk of early and late adverse effects in the breast is real [13][14][15][16].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Body mass index, correlated to breast size and brassiere size, has also been linked to the risk of acute skin reactions and to late cosmesis [10][11][12]. Not all studies are confirmatory, but the weight of evidence suggests that the association between the size of the breast and the risk of early and late adverse effects in the breast is real [13][14][15][16].…”
Section: Introductionmentioning
confidence: 99%
“…Assuming dose distribution matters, it is not known if residual dose inhomogeneity in patients treated using 3D dosimetry explains a significant component of late adverse effects in large breasted women. Other factors associated with late adverse effects, including age [20], scar visibility, large excision volume, post-operative complications [12], smoking and adjuvant chemotherapy [11,21], appear unlikely to provide an adequate alternative explanation, since they are not all associated with breast size. Against this background, a retrospective analysis has been undertaken to test the hypothesis that residual dose inhomogeneity of whole breast radiotherapy delivered in conformity with ICRU recommendations (95-107% of reference) [22,23] accounts for a significant part of the association between breast size and risk of late adverse effects.…”
Section: Introductionmentioning
confidence: 99%
“…The film outlines were drawn on the phantom to permit accurate placements of further film as required (for each tangential beam). The points for film dosimetry were chosen as they are reported sites of skin toxicity for breast irradiation and as such are of clinical interest (Donovan et al 2007, Fernando et al 1996.…”
Section: Film Dosimetrymentioning
confidence: 99%
“…[3][4][5][6] The discrepancy in patient radiosensitivity is attributed then to patient genetic backgrounds and/or predispositions to adverse reactions. Previously, others group have attempted to correlate radiosensitivity in patient populations with in vitro assessments of patient initial DNA damage and repair efficacies, single nucleotide polymorphism (SNPs) in DNA repair genes, lymphocyte apoptosis efficiencies, fibroblast clonogenic survival, and chromosomal aberrations in response to RT.…”
Section: Introductionmentioning
confidence: 99%
“…Previously, others group have attempted to correlate radiosensitivity in patient populations with in vitro assessments of patient initial DNA damage and repair efficacies, single nucleotide polymorphism (SNPs) in DNA repair genes, lymphocyte apoptosis efficiencies, fibroblast clonogenic survival, and chromosomal aberrations in response to RT. [3][4][5][6] Even with large patient cohorts and multiple studies, these reports have failed to validate any potential predictive biomarkers for RT-induced skin toxicities. RT inadvertently affects immune cells and triggers a pro-inflammatory response leading to various immune responses with a different extent for the wound healing response, which may account for the onset of acute skin toxicities following radiation tissue damage.…”
Section: Introductionmentioning
confidence: 99%