Factors Affecting Choroidal Vascular Density in Normal Eyes: Quantification Using En Face Swept-Source Optical Coherence Tomography

Fujiwara, Atsushi; Morizane, Yuki; Hosokawa, Mio; Kimura, Shuhei; Kumase, Fumiaki; Shiode, Yusuke; Doi, Shinichiro; Hirano, Masayuki; Toshima, Shinji; Hosogi, Mika; Shiraga, Fumio

doi:10.1016/j.ajo.2016.07.006

Cited by 49 publications

(37 citation statements)

References 30 publications

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“…In our current study, the CVD in amblyopic and fellow eyes exceeded 59% (59.11 ± 0.66% and 59.23 ± 0.81%, respectively), consistent with a report by Terada et al However, the CVD in normal control eyes (59.29 ± 0.74%) also exceeded 59%, resulting in comparable CVDs among different eye conditions. In normal eyes, CVD has been reported to correlate positively with SFCT [9]. However, SFCT was slightly thicker in Terada's control group (351.9 ± 60.7 µm) than in our control group (323.8 ± 69.1 µm).…”

Section: Discussioncontrasting

confidence: 74%

“…CVD was quanti ed by binarizing the en-face image with reference to the report by Fujiwara et al [9]. The 3-dimensional (3D) SS-OCT images, which covered a 12 × 9-mm 2 area with a scan density of 512 × 256, were reconstructed as en-face images attened with Bruch's membrane using dedicated software tools (EnView version 1.0.1; Topcon Corporation).…”

Section: Quanti Cation Of Choroidal Vascular Density and Subfoveal Chmentioning

confidence: 99%

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Choroidal Vessel Density in Unilateral Hyperopic Amblyopia Using en-Face Optical Coherence Tomography

Araki

Miki

Goto

et al. 2020

Preprint

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BackgroundStructural changes of the choroid, such as choroidal thickening, have been indicated in amblyopic eyes with hyperopic anisometropia as compared to fellow or healthy eyes. The purpose of the present study was to investigate choroidal vascular density (CVD) in children with unilateral hyperopic amblyopia.MethodsThis study included 88 eyes of 44 patients with unilateral amblyopia due to hyperopic anisometropia with or without strabismus and 29 eyes of 29 age-matched normal controls. The CVD of Haller's layer was quantified from en-face images constructed by 3-dimensional swept-source optical coherence tomography images flattened relative to Bruch's membrane. The analysis area was a 3×3-mm square of macula after magnification correction. Relationships between CVD and other parameters [best-corrected visual acuity (BCVA), refractive error, axial length and subfoveal choroidal thickness (SFCT)] were investigated, and CVDs were compared between amblyopic, fellow, and normal control eyes.ResultsMean CVD was 59.1±0.7% in amblyopic eyes, 59.2±0.8% in fellow eyes, and 59.3±0.7% in normal control eyes. CVD showed a significant positive relationship with SFCT (p=0.005), but no relationships with other parameters. No significant differences in CVD were evident among amblyopic, fellow, and normal control eyes after adjusting for SFCT (p=0.502).ConclusionsCVD was unrelated to BCVA, and CVD did not differ significantly among amblyopic, fellow and normal control eyes. These results suggest that the local CVD of Haller's layer is unaffected in unilateral hyperopic amblyopic eyes.

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Section: Discussioncontrasting

confidence: 74%

Section: Quanti Cation Of Choroidal Vascular Density and Subfoveal Chmentioning

confidence: 99%

Choroidal Vessel Density in Unilateral Hyperopic Amblyopia Using en-Face Optical Coherence Tomography

Araki

Miki

Goto

et al. 2020

Preprint

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“…According to previous studies in adults, the choroidal thickness tended to decrease with increasing age. 10,11 As reported by Fujiwara et al, 30 choroidal vascular density had negative association with age in healthy subjects aged older than 30 years. Furthermore, Sohn et al 31 found that the amount of fibrillar collagen and cellular components of the choroid decreased with increasing age in eyes from donors aged older than 50 years.…”

Section: Discussionmentioning

confidence: 60%

Features of the Choroidal Structures in Myopic Children Based on Image Binarization of Optical Coherence Tomography

Wen

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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To evaluate the features of the choroidal structures in the eyes of myopic children obtained by enhanced depth imaging optical coherence tomography (EDI-OCT). METHODS. Ninety-six myopic children with low to moderate myopia (spherical equivalent refractive error [SER],-5.75 to-1.00 diopter) were included in this cross-sectional study. Ocular biometrics were measured using an optical low-coherence reflectometry device. Data of the choroidal structures extracted from a 7500-μm cross-sectional arc of the choroid extending from the temporal optic disc margin, including the total choroidal area, luminal area, stromal area, and choroidal vascularity index, were determined by image binarization of the EDI-OCT. Associations between demographic factors, ocular parameters, and choroidal structures were evaluated using univariate and multiple linear regression analyses. RESULTS. The study participants (mean age, 11.02 ± 1.70 years) had a mean axial length (AL) of 24.94 ± 0.70 mm. The mean total choroidal area was 2.64 ± 0.49 mm 2 (luminal area, 1.68 ± 0.32 mm 2 ; stromal area, 0.95 ± 0.19 mm 2), and the choroidal vascularity index was 0.64 ± 0.03. Multiple regression analysis showed that the luminal area was significantly associated with the AL (standard β =-0.24, P = 0.022) after adjusting for sex and corneal radius (CR), whereas the stromal area (standard β =-0.30, P = 0.003) and choroidal vascularity index (standard β = 0.36, P = 0.001) were significantly associated with age after adjusting for sex, CR, and lens thickness (LT). Sex, CR, LT, and SER showed no significant association with choroidal structures after adjusting for age and AL (all P > 0.05). CONCLUSIONS. The luminal area of the choroid tends to decrease with a longer AL, whereas the stromal area tends to decrease with increasing age in myopic children. These findings require further exploration in a longitudinal study.

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“…One possible method to understand retinal traction in LMH and MPH with a wide observation range is to assess the retina not only with 1 cross-sectional image but also from a coronal view. [16][17][18] The recent advent of sweptsource OCT, which is highly penetrating and has a high scan speed, has made it possible to capture 3-dimensional images of the structure of the retina. In particular, en face images, which are coronal-view images generated after computerized flattening along a specific retinal layer boundary, enable layer-by-layer analysis of retinal folds and deformation of the foveal aperture induced by retinal traction over a wide observation range.…”

mentioning

confidence: 99%

Assessment of Lamellar Macular Hole and Macular Pseudohole With a Combination of En Face and Radial B-scan Optical Coherence Tomography Imaging

Hirano

Morizane

Kimura

et al. 2018

American Journal of Ophthalmology

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Factors Affecting Choroidal Vascular Density in Normal Eyes: Quantification Using En Face Swept-Source Optical Coherence Tomography

Cited by 49 publications

References 30 publications

Choroidal Vessel Density in Unilateral Hyperopic Amblyopia Using en-Face Optical Coherence Tomography

Choroidal Vessel Density in Unilateral Hyperopic Amblyopia Using en-Face Optical Coherence Tomography

Features of the Choroidal Structures in Myopic Children Based on Image Binarization of Optical Coherence Tomography

Assessment of Lamellar Macular Hole and Macular Pseudohole With a Combination of En Face and Radial B-scan Optical Coherence Tomography Imaging

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