Factors affecting drug encapsulation and stability of lipid–polymer hybrid nanoparticles

Cheow, Wean Sin; Hadinoto, Kunn

doi:10.1016/j.colsurfb.2011.02.033

Cited by 237 publications

(154 citation statements)

References 22 publications

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“…Although nanoprecipitation is highly effective and can be scaled up readily for a larger production, this method is still limited by the fact that substances to be encapsulated must be soluble in water-miscible organic solvents (Cheow and Hadinoto, 2011). Moreover, only a low encapsulation efficiency of water-soluble substances can be achieved because of the leakage of these substances into the aqueous phase (Su et al, 2011).…”

Section: Lipid-polymer Hybrid Nanoparticlesmentioning

confidence: 99%

Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come

2016

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Section: Lipid-polymer Hybrid Nanoparticlesmentioning

confidence: 99%

Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come

2016

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“…To be able to encapsulate sufficient amounts of antibiotics, charge reversal of the lipid by adding counterionic surfactants has successfully been used. [103] Alternatively, one can complex the antibiotic with polyelectrolytes. [104] This complexation is fast, efficient, organic solvent free and does not require specialized equipment.…”

Section: Encapsulation Efficiencymentioning

confidence: 99%

Lipid and polymer nanoparticles for drug delivery to bacterial biofilms

Forier

Raemdonck

Smedt

et al. 2014

Journal of Controlled Release

370

320

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Biofilms are matrix-enclosed communities of bacteria that show increased antibiotic resistance and the capability to evade the immune system. They can cause recalcitrant infections which cannot be cured with classical antibiotic therapy. Drug delivery by lipid or polymer nanoparticles is considered a promising strategy for overcoming biofilm resistance. These particles are able to improve the delivery of antibiotics to the bacterial cells, thereby increasing the efficacy of the treatment. In this review we give an overview of the types of polymer and lipid nanoparticles that have been developed for this purpose. The antimicrobial activity of nanoparticle encapsulated antibiotics compared to the activity of the free antibiotic is discussed in detail. In addition, targeting and triggered drug release strategies to further improve the antimicrobial activity are reviewed. Finally, ample attention is given to advanced microscopy methods that shed light on the behavior of nanoparticles inside biofilms, allowing further optimization of the nanoformulations. Lipid and polymer nanoparticles were found to increase the antimicrobial efficacy in many cases. Strategies such as the use of fusogenic liposomes, targeting of the nanoparticles and triggered release of the antimicrobial agent ensured the delivery of the antimicrobial agent in close proximity of the bacterial cells, maximizing the exposure of the biofilm to the antimicrobial agent. The majority of the discussed papers still present data on the in vitro anti-biofilm activity of nanoformulations, indicating that there is an urgent need for more in vivo studies in this field.

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“…The particle size and surface morphology were examined by Scanning electron microscopy (ZEISS EVO 18 Special Edition). The percentage of encapsulation was determined (Cheow and Hadinoto, 2011).…”

Section: Physical Characterisation Of Antimicrobial Loaded Liposomesmentioning

confidence: 99%

Determination of Minimum Inhibitory Concentration of Liposomes: A Novel Method

Manuel¹,

Abdulrahman²

2017

Int.J.Curr.Microbiol.App.Sci

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Factors affecting drug encapsulation and stability of lipid–polymer hybrid nanoparticles

Cited by 237 publications

References 22 publications

Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come

Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come

Lipid and polymer nanoparticles for drug delivery to bacterial biofilms

Determination of Minimum Inhibitory Concentration of Liposomes: A Novel Method

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