A detailed understanding of the engineering properties for grouted sand is a key concern in foundation engineering projects containing sand layers. In this research, experiments of grouting with various grain sizes of sand specimens using a new type of improved chemical material-urea formaldehyde resin mixed with oxalate curing agent (UF-OA), which has rarely been used as grout in the reinforcement of soft foundations, were conducted on the basis of a self-developed grouting test system. After grouting tests, the effects on the mechanical behaviors of grouted sand specimens were investigated through uniaxial compression tests considering the grain size, the presence or absence of initial water in sand, and the curing time for grouted sand. Experimental results show that with the increase in the grain size and the presence of initial water in the sand specimen, the values of uniaxial compressive strength (UCS) and elastic moduli (E) of the grouted specimens decreased obviously, indicating that the increase of grain size and the presence of initial water have negative impacts on the mechanical behaviors of grouted sand; the peak strains (ε c) were almost unchanged after 14 days of curing; no brittle failure behavior occurred in the grouted specimens, and desirable ductile failure characteristics were distinct after uniaxial compression. These mechanical behaviors were significantly improved after 14 days of curing. The micro-structural properties obtained by scanning electron microscopy (SEM) of the finer grouted sand indicate preferable filling performance to some extent, thereby validating the macroscopic mechanical behaviors.