Factors affecting formiminoglutamic acid excretion in vitamin B12 deficiency

Marston, H. R.; Allen, S.H.G.

doi:10.1042/bj1160681

Cited by 5 publications

(3 citation statements)

References 31 publications

(18 reference statements)

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“…Homocysteine was less active [2] or inactive [11] and cystine was inactive [11]. Choline decreased excretion [7] or had no effect [2,11]. Thus, our results with choline are in conformity with the last mentioned finding.…”

Section: Discussionsupporting

confidence: 81%

“…It was the purpose of this study to see, whether the methionine effect is a specific one to this compound or whether it is shared by another sulfur containing amino acid or by other compounds providing labile methyl groups, i.e. cysteine and choline.Methionine is also known to restore the impaired ability of vitamin B12-deficient rats and chicks to deal with the degradation of histidine and to reduce the increased excretion of formiminoglutamic acid (FIGLU) follo wing a histidine load [4,7,9,10,11]. Since feeding an unheated sbf diet, like other diets inducing vitamin B12 deficiency, increases FIGLU excretion [3], the effect of methionine, cysteine and choline on this metabolic parameter was also studied.…”

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confidence: 99%

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Effects of Sulfur-Amino Acids and Choline on Vitamin B<sub>12</sub>-Deficient Rats

Edelstein¹,

Guggenheim²

1971

Ann Nutr Metab

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Rats were fed a diet based on unheated soybean flour without vitamin B₁₂ added. This diet leads to a depletion of vitamin B₁₂ as evinced from a decrease in liver concentration of the vitamin and an increased urinary excretion of methylmalonic acid following a load of propionate. Urinary excretion of formiminoglutamic acid after a histidine load was likewise increased. Supplementation of this diet with either methionine or cysteine improved weight gain, increased liver level of vitamin B₁₂ and decreased excretion of methylmalonic and formiminoglutamic acids. Choline raised liver vitamin B₁₂ and decreased excretion of methylmalonic acid. Addition of both choline and methionine to the diet increased liver vitamin B₁₂ more than choline or methionine alone and decreased excretion of formiminoglutamic acid more than choline alone.

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Section: Discussionsupporting

confidence: 81%

mentioning

confidence: 99%

Effects of Sulfur-Amino Acids and Choline on Vitamin B<sub>12</sub>-Deficient Rats

Edelstein¹,

Guggenheim²

1971

Ann Nutr Metab

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“…There was no indication, in the relatively small number of animals observed, of a reduction in the rate at which acetate n as metabolized by sheep in which the cffective concentration of pteroylglutamic acid had been reduced, and a partial disturbance of histidine catabolism induced, by administration of aminopterin (Marston & Allen, 1970). The observations included ten clearance tests on four pair-fed sheep, one each on a singlc vitamin B,,-deficient and a single vitamin €&,-treated sheep on a restricted food intake and three on a vitamin B,,-treated sheep whose food intake was not restricted.…”

Section: Vol 27mentioning

confidence: 95%

Production within the rumen and removal from the blood-stream of volatile fatty acids in sheep given a diet deficient in cobalt

1972

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I . The production and metabolism of volatile fatty acids were stndied in sheep offered a cobalt-deficient diet.2. The molai proportions of acetic (60 "/o), propionic (zh x) and butyric (14 ?(, ) acids in the rumen fluids of' sheep giccn thc Co-deficient diet, but whose stores of vitamin B,, were adequate, were similar before arid after administration of an oral supplement of Co.3. In pair-fed sheep, one member of which was vitamin BIZ-deficient and the other (control) trcatcd with vitamin B,, parenterally, the concentrations after feeding of both totill and individual volatile fatty acids in the blood tended to be higher in deficient than in contro! sheep.1. Following injection of thc respective salts of individual volatile fatty acids into the blood-stream, formate clearance was apparently not affected, whereas that of acetate was slightly, and that of propionate very significantIy, delayed in vitamin B,,-dcficient sheep compared with pair-fed control animals.5 . Acetate metabolism was retarded in the prescncc of propionate; the effect was greater in deficient than in pair-fed control sheep.6 . The hypothesis is advanced that it is the failure to metabolize propionate at the normal rate that leads to the progressive loss of appetite in vitamin BIZ-deficient sheep.LOSS of appetite, the first sign of vitamin B,, deficiency seen in sheep that consume a cobalt-deficient diet, occurs when the concentration of vitamin R,, in the liver is reduced to about 0.1 pgig h e r tissue (Marston, 1970).Observation of pair-fed animals showed that, whereas the animal whose stores of vitamin B,, were adequate ate the whole of its ration in 1-2 h, the deficient member of the pair might take 24 h to consume the same amount of food. Following a 24 h fast, a deficient sheep sometimes ate ravenously for a short time and then left the remainder of its ration untouched for several hours.The :issociation, in deficient sheep. between consumption of small quantities of food a i d impairment of appetite led to a search for a metabolite(s) which accumulated in the blood-stream after feeding. As the ruminant derives the major portion of its cncrgy from volatile fatty acids produced by fermentation, a study was made of some aspects of the production, absorption and utilization of these acids in shecp given the Co-deficient diet. Lack of Co in the diet had no apparent influence on production or absorption of the volatile fatty acids produced by micro-organisms mithin the rumen. In those animals in which there was a lack of vitamin BIZ in the tissues, homever,

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Biosynthesis of 1-0-(1′-Alkenyl)glycerolipids (Plasmalogens)

Paltauf¹

1983

Ether Lipids

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Factors affecting formiminoglutamic acid excretion in vitamin B12 deficiency

Cited by 5 publications

References 31 publications

Effects of Sulfur-Amino Acids and Choline on Vitamin B<sub>12</sub>-Deficient Rats

Effects of Sulfur-Amino Acids and Choline on Vitamin B<sub>12</sub>-Deficient Rats

Production within the rumen and removal from the blood-stream of volatile fatty acids in sheep given a diet deficient in cobalt

Biosynthesis of 1-0-(1′-Alkenyl)glycerolipids (Plasmalogens)

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