Factors affecting knee cartilage volume in healthy men

Cicuttini, Flavia Maria; Wluka, Anita E.; Bailey, Michael; O’Sullivan, Richard; Poon, Cathy; Yeung, S; Ebeling, Peter R.

doi:10.1093/rheumatology/keg073

Cited by 104 publications

(107 citation statements)

References 28 publications

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“…BMI was not associated with incident knee joint space narrowing (28) and the loss of knee cartilage volume in OA knees (19), and knee cartilage volume in overweight children did not differ significantly from that in normal children, either cross-sectionally or longitudinally (29). However, BMI has been inversely associated with tibial cartilage volume standardized for bone size (reflecting cartilage thickness) in men (21). These inconsistencies are likely caused by low sensitivity of radiographic assessment, differences in disease groups, generally small sample sizes, and differing age groups.…”

Section: Discussionmentioning

confidence: 98%

“…In contrast, magnetic resonance imaging (MRI) can visualize joint structure directly and is recognized as a valid, accurate, and reproducible tool to measure articular cartilage defects (10 -14), volume, thickness, and subchondral bone size (15)(16)(17)(18)(19)(20). However, the results from early MRI studies on the association between knee cartilage and BMI are contradictory because they are generally from small samples (19,21,22). Cartilage defects (G. Jones, unpublished data) and bone size (23) may also be important in the pathogenesis of knee OA, but there is little information on the associations among BMI, knee cartilage defects, and knee subchondral bone size.…”

Section: Introductionmentioning

confidence: 99%

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Knee Structural Alteration and BMI: A Cross‐sectional Study

et al. 2005

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DING, CHANGHAI, FLAVIA CICUTTINI, FIONA SCOTT, HELEN COOLEY, AND GRAEME JONES. Knee structural alteration and BMI: a cross-sectional study. Obes Res. 2005;13:350 -361. Objective: To describe the associations among BMI, knee cartilage morphology, and bone size in adults. Research Methods and Procedures:A cross-sectional convenience sample of 372 male and female subjects (mean age, 45 years; range, 26 to 61 years) was studied. Knee articular cartilage defect score (0 to 4) and prevalence (defect score of Ն2), volume, and thickness, as well as bone surface area and/or volume, were determined at the patellar, tibial, and femoral sites using T1-weighted fat-saturation magnetic resonance imaging. Height, weight, BMI, and radiographic osteoarthritis were measured by standard protocols. Results:In multivariate analysis in the whole group, BMI was significantly associated with knee cartilage defect scores (␤: ϩ0.016/kg/m 2 to ϩ0.083/kg/m 2 , all p Ͻ 0.05) and prevalence (odds ratio: 1.05 to 1.12/kg/m 2 , all p Ͻ 0.05 except for the lateral tibiofemoral compartment). In addition, BMI was negatively associated with patellar cartilage thickness only (␤ ϭ Ϫ0.021 mm/kg/m 2 ; p ϭ 0.039) and was positively associated with tibial bone area (medial: ␤ ϭ ϩ7.1 mm 2 /kg/m 2 , p ϭ 0.001; lateral: ␤ ϭ ϩ3.2 mm 2 /kg/ m 2 , p ϭ 0.037). Those who were obese also had higher knee cartilage defect severity and prevalence and larger medial tibial bone area but no significant change in cartilage volume or thickness compared with those of normal weight.Discussion: This study suggests that knee cartilage defects and tibial bone enlargement are the main structural changes associated with increasing BMI particularly in women. Preventing these changes may prevent knee osteoarthritis in overweight and obese subjects.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Knee Structural Alteration and BMI: A Cross‐sectional Study

et al. 2005

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“…18,19 This is exacerbated in varus malalignment, which has been associated with increased joint compression 20 and cartilage pressure, 21 as well as decreased cartilage thickness 22 and volume 9 and increased stiffness of the subchondral bone. 23 Biomechanical factors in varus malalignment include greater adduction moment 19 and medial ligament laxity 25 with a consequent increase in compensatory muscle contraction, 26 particularly by quadriceps motor units.…”

Section: Discussionmentioning

confidence: 99%

Static knee alignment is associated with the risk of unicompartmental knee cartilage defects

Janakiramanan

Teichtahl

Wluka

et al. 2007

Journal Orthopaedic Research

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Although knee malalignment is a risk factor for the progression of unicompartmental knee osteoarthritis (OA), it is unclear how this relationship is mediated. Cartilage defects are known to predate cartilage loss and the onset of knee OA, and it may be that knee malalignment increases the risk of unicompartmental knee cartilage defects. Knee radiographs and MRI were performed on a total of 202 subjects, 36.6% of whom had radiographic knee OA, to determine the relationship between static knee alignment and knee cartilage defects. Analyses were performed for the entire cohort, as well as for healthy and OA subgroups. For every 18 increase in a valgus direction, there was an associated reduced risk of the presence of cartilage defects in the medial compartment of subjects with knee OA (p ¼ 0.02), healthy subjects (p ¼ 0.002), and the combined (p < 0.001) group. Moreover, for every 18 increase in a valgus direction, there was an associated increased risk of the presence of lateral cartilage defects in the OA group (p ¼ 0.006), although the relationship between change toward genu valgum and lateral compartment cartilage defects did not persist for the healthy group (p ¼ 0.16). This cross-sectional study has demonstrated that knee alignment is associated with the risk for compartment specific knee cartilage defects in both healthy and arthritic people. Given that the natural history of cartilage volume reduction appears to be predated by the presence of cartilage defects, whether knee alignment affects the longitudinal progression from cartilage defects to cartilage loss requires further examination. ß

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“…Documentation is increasing on the gender differences (58)(59)(60) and 'baseline' rates of loss of cartilage in osteoarthritis (61) and after injuries and interventions such as partial menisectomy (62). The effects of genetics on cartilage volume are also being investigated (63).…”

Section: Should Mri Be Used To Determine Entry Criteria For Clinical mentioning

confidence: 99%

“…The effects of genetics on cartilage volume are also being investigated (63). In one study, the rate of cartilage loss in the patella was poorly correlated with cartilage loss in the tibia (62), demonstrating that these compartments should be considered separately in clinical trials. In one study, tibial and femoral changes were found to be related, suggesting that it might be possible to measure tibial volume alone (61); however, other studies found only a moderate correlation (64).…”

Section: Should Mri Be Used To Determine Entry Criteria For Clinical mentioning

confidence: 99%

MRI for development of disease-modifying osteoarthritis drugs

Burstein

2006

NMR Biomed.

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MRI has advantages as an imaging modality for drug development through its potential to provide information regarding localized morphological parameters, in addition to metrics of the structural and molecular state of cartilage. These metrics have the potential to provide earlier indications of pathology and may progress more rapidly than radiographic measures. These combined scans of localized morphology and matrix parameters will most likely provide a fuller assessment of cartilage state and will improve the cost and practicality of an overall evaluation of cartilage status by MRI. In the first part of this review, the relevant parameters are presented in terms of the information content they might provide in the drug development process. In the second part, applications of the MRI parameters in preclinical and clinical drug development are presented.

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Factors affecting knee cartilage volume in healthy men

Cited by 104 publications

References 28 publications

Knee Structural Alteration and BMI: A Cross‐sectional Study

Knee Structural Alteration and BMI: A Cross‐sectional Study

Static knee alignment is associated with the risk of unicompartmental knee cartilage defects

MRI for development of disease-modifying osteoarthritis drugs

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