Aim There are uncertainties regarding the modification effects of season and temperature on the relationship between air pollution and mortality. This study aims to examine the effects of season and temperature on mortality associated with particulate matter less than 10 μm in diameter (PM 10 ) in Tianjin, China. Methods Time-series analysis was used to explore the modification effects of season and temperature on the association between PM 10 and cause-specific mortality in Tianjin between 2006 and 2009. The causes studied were overall nonaccidental mortality and subcategories of cardiovascular, respiratory, cardiopulmonary, stroke, and ischemic heart diseases (IHD). Results The association between PM 10 and mortality showed a strong seasonal pattern and the effects of PM 10 on causespecific mortalities were strongest for high temperature days. Generally, the adverse effects were stronger in summer than for other seasons, except for respiratory mortality. In the summer period, a 10 μg/m 3 increase in PM 10 at 0-1 days was associated with an increase in mortality for nonaccidental (0.95 %, 95 % confidence interval [CI]: 0.45, 1.45), cardiovascular (1.40 %, 95 %CI: 0.77, 2.03), cardiopulmonary (1.37 %, 95 %CI: 0.77, 1.98), IHD (1.55 %, 95 %CI: 0.73, 2.37), and stroke (1.27 %, 95 % CI: 0.37, 2.12) causes. The overall increase in mortality per 10 μg/m 3 increase in PM 10 was 0.42 % (95 %CI: 0.26, 0.58) for nonaccidental, 0.41 % (95 %CI: 0.21, 0.62) for cardiovascular, 0.46 % (95 %CI: 0.26,0.65) for cardiopulmonary, 0.57 % (95 %CI: 0.30, 0.84) for IHD, and 0.32 % (95 %CI: 0.03,0.61) for stroke. At high temperatures (≥23.8°C), a 10 μg/m 3 increase in PM 10 at 0-1 days was associated with an increase in mortality of 0.90 % (95 %CI: 0.61,1.19) for non-accidental, 1.01 % for cardiovascular, 1.40 % (95 %CI: 0.55, 2.27) for respiratory, 1.06 % (95 %CI: 0.71, 1.41) for cardiopulmonary, 1.47 % (95 %CI: 1.00, 1.94) for IHD, and 0.75 % (95 %CI: 0.24, 1.28) for stroke. In addition, the PM 10 effects of high temperature days were stronger for those aged 65 years and over. Conclusion Season and temperature could modify the adverse effects of PM 10 . An increase in hot summer days caused by climate change may enhance the risks of air pollution on human health. More attention should be paid to older populations, especially in summer and days with high temperatures.