Factors affecting occurrence of twin pregnancy after double embryo transfer on day 3

Kim, Myo Sun; Kim, Jihee; Jee, Byung Chul; Suh, Chang Suk; Kim, Seok Hyun

doi:10.1111/jog.12687

Cited by 5 publications

(9 citation statements)

References 21 publications

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“…It is well known that maternal age is the most significant indicator for double embryo implantation following DET (Kim et al, 2015;Martin et al, 2016). Various studies have consistently shown that oocytes from women over 40 years of age have decreased quality (Alasmari, Son & Dahan, 2016;Hourvitz et al, 2009); subsequently, the resultant embryos will show declining developmental potentials (Marquez et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

“…Martin et al (2016) specified the strongest negative predictor of double embryo implantation was age ≥35 years compared to age <35 years after double embryo transfer (DET). Kim et al (2015) reported maternal age ≤35 years was the cutoff value to predict twin pregnancy following DET. Therefore, recommendations for eSET have focused mainly on women aged <35 years who have a favorable prognosis (Thurin et al, 2004).…”

Section: Introductionmentioning

confidence: 98%

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The effect on twinning rate of transferring double vitrified-warmed embryos in women of advanced reproductive age: a retrospective study

Xue

2020

PeerJ

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Twin pregnancies are associated with greater risk of neonatal morbidity and mortality than a singleton. This study was performed to investigate the twin pregnancy rate when two vitrified-warmed embryos are transferred in women of advanced reproductive age (≥35 years at the time of oocyte retrieval) and to evaluate the implications of findings in selecting candidates for elective single embryo transfer (eSET). A retrospective analysis of data which included 2,038 women aged 35–45 years, who underwent vitrified-warmed double embryo transfer (DET), from January 2013 to December 2016 was undertaken. Pregnancy and twin rates were estimated after stratifying by prognostic profile. The twin pregnancy rate was lower in women with poor prognosis (12/96, 12.5%) as compared with that in women with favorable prognosis (102/374, 27.3%) and average prognosis (78/346, 22.5%) with significant differences (P < 0.05). The twin rate for women with favorable prognosis was 29.2% (70/240) in the cycles of women aged 35–37 years, 26.8% (26/97) in the cycles of women aged 38–40 years and 16.2% (6/37) in the cycles of women >40 years. The twin rate for women with average prognosis was 25.8% (51/198) in the cycles of women aged 35–37 years, 22.0% (22/100) in the cycles of women aged 38–40 years and 10.4% (5/48) in the cycles of women >40 years. The twin rate for women with poor prognosis was 15.3% (9/59) in the cycles of women aged 35–37 years, 10.3% (3/29) in the cycles of women aged 38–40 years and 0% (0/8) in the cycles of women >40 years. From these results, it was concluded that women with a favorable or average prognosis have a high risk of twin pregnancies. The finding can be used to guide future practice: that is, performing eSET in women with favorable or average prognosis and DET in women with poor prognosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

The effect on twinning rate of transferring double vitrified-warmed embryos in women of advanced reproductive age: a retrospective study

Xue

2020

PeerJ

View full text Add to dashboard Cite

show abstract

“…It is well known that maternal age is the most significant indicator for double embryo implantation following DET (Kim et al 2015;Martin et al 2016). Various studies have consistently shown that oocytes from women over 40 years of age have decreased quality (Alasmari et al 2016;Hourvitz et al 2009); subsequently, the resultant embryos will show declining developmental potentials (Marquez et al 2000).…”

Section: Discussionmentioning

confidence: 99%

“…Myo sun kim et al reported maternal age ≤35 years was the cut-off value to predict twin pregnancy following DET (Kim et al 2015). Therefore, recommendations for eSET have focused mainly on women aged < 35 years who have a favorable prognosis (Thurin et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Peer Review #2 of "The effect on twinning rate of transferring double vitrified-warmed embryos in women of advanced reproductive age: a retrospective study (v0.2)"

2020

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Twin pregnancies are associated with greater risk of neonatal morbidity and mortality than a singleton. This study was performed to investigate the twin pregnancy rate when two vitrified-warmed embryos are transferred in women of advanced reproductive age (≥ 35 years at the time of oocyte retrieval) and to evaluate the implications of findings in selecting candidates for elective single embryo transfer (eSET). A retrospective analysis of data which included 2038 women aged 35 to 45 years, who underwent vitrified-warmed double embryo transfer (DET), from January 2013 and December 2016 was undertaken. Pregnancy and twin rates were estimated after stratifying by prognostic profile. The twin pregnancy rate was lower in women with poor prognosis (12/96, 12.5%) as compared with that in women with favorable prognosis (102/374, 27.3%) and average prognosis (78/346, 22.5%) with significant differences (P<. 05). The twin rate for women with favorable prognosis were 29.2% (70/240) in the cycles of women aged 35-37 years, 26.8% (26/97) in the cycles of women aged 38-40 years, and 16.2% (6/37) in the cycles of women >40 years. The twin rate for women with average prognosis were 25.8% (51/198) in the cycles of women aged 35-37 years, 22.0% (22/100) in the cycles of women aged 38-40 years, and 10.4% (5/48) in the cycles of women >40 years. The twin rate for women with poor prognosis were 15.3% (9/59) in the cycles of women aged 35-37 years, 10.3% (3/29) in the cycles of women aged 38-40 years, and 0% (0/8) in the cycles of women >40 years. From these results, it was concluded that women with a favorable or average prognosis have a high risk of twin pregnancies. The finding can be used to guide future practice: i.e. performing eSET in women with favorable or average prognosis and DET in women with poor prognosis.

show abstract

Section: Introductionmentioning

confidence: 99%

Peer Review #1 of "The effect on twinning rate of transferring double vitrified-warmed embryos in women of advanced reproductive age: a retrospective study (v0.2)"

Cirillo¹

2020

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Twin pregnancies are associated with greater risk of neonatal morbidity and mortality than a singleton. This study was performed to investigate the twin pregnancy rate when two vitrified-warmed embryos are transferred in women of advanced reproductive age (≥ 35 years at the time of oocyte retrieval) and to evaluate the implications of findings in selecting candidates for elective single embryo transfer (eSET). A retrospective analysis of data which included 2038 women aged 35 to 45 years, who underwent vitrified-warmed double embryo transfer (DET), from January 2013 and December 2016 was undertaken. Pregnancy and twin rates were estimated after stratifying by prognostic profile. The twin pregnancy rate was lower in women with poor prognosis (12/96, 12.5%) as compared with that in women with favorable prognosis (102/374, 27.3%) and average prognosis (78/346, 22.5%) with significant differences (P<. 05). The twin rate for women with favorable prognosis were 29.2% (70/240) in the cycles of women aged 35-37 years, 26.8% (26/97) in the cycles of women aged 38-40 years, and 16.2% (6/37) in the cycles of women >40 years. The twin rate for women with average prognosis were 25.8% (51/198) in the cycles of women aged 35-37 years, 22.0% (22/100) in the cycles of women aged 38-40 years, and 10.4% (5/48) in the cycles of women >40 years. The twin rate for women with poor prognosis were 15.3% (9/59) in the cycles of women aged 35-37 years, 10.3% (3/29) in the cycles of women aged 38-40 years, and 0% (0/8) in the cycles of women >40 years. From these results, it was concluded that women with a favorable or average prognosis have a high risk of twin pregnancies. The finding can be used to guide future practice: i.e. performing eSET in women with favorable or average prognosis and DET in women with poor prognosis.

show abstract

Factors affecting occurrence of twin pregnancy after double embryo transfer on day 3

Abstract: Younger age, higher bodyweight, and better embryo quality are all associated with a higher incidence of twin pregnancy after double embryo transfer on day 3. Single embryo transfer might be advisable for couples with risk factors for twin pregnancy.

Cited by 5 publications

References 21 publications

The effect on twinning rate of transferring double vitrified-warmed embryos in women of advanced reproductive age: a retrospective study

The effect on twinning rate of transferring double vitrified-warmed embryos in women of advanced reproductive age: a retrospective study

Peer Review #2 of "The effect on twinning rate of transferring double vitrified-warmed embryos in women of advanced reproductive age: a retrospective study (v0.2)"

Peer Review #1 of "The effect on twinning rate of transferring double vitrified-warmed embryos in women of advanced reproductive age: a retrospective study (v0.2)"

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