Factors Affecting Pathogenicity of Serratia Marcescens for Mice

Detection of Fibrinolytic and Elastase Activity Among Clinical Isolates of <i>Serratia Marcescen</i><i>s</i>

“…To date, little work has been done with respect to the host-parasite relationships of this particular microorganism [3,11,13,14,16,20,25,29,30,31,38], It has been known for a long time that S. marcescens strains elaborate pathobiologically powerful endotoxins which are capable of eliciting generalized Shwartzman reactions [1,6]. Very recently, Q uarles et al [24] demonstrated dialyzable toxic products (maximal molecular weight 15,000) produced by a strain of S. marcescens that had been maintained in an ingeniously conceived goat artificial kid ney fermentor system; it was shown that when the population of bacterial cells had exceeded lO'/ml, and when the cells had reached the stationary phase of growth, the experimental animals became toxemic, leukopenic, and developed fever.…”