Factors affecting postmusculoskeletal tumour surgery wound problem treatment with negative pressure wound therapy

Abstract

The aim of the study is to investigate the risk factors identified in literature that have been associated with prolonged Negative Pressure Wound Therapy (NPWT). Our study included patients who developed local wound problems after bone or soft tissue sarcoma surgery with negative margin at our clinic between 2012 and 2018 and treated with NPWT. All patients were followed up of at least 6 months. Sex, albumin level, skin infiltration, type of wound problem, postoperative intensive care unit (ICU) requirement, and intraoperative blood loss were found to be influential factors on NPWT > 10 sessions. We conclude that treatment may be prolonged and the necessary precautions need to be taken in patients with an impaired preoperative nutritional condition, with intraoperative high amount of blood loss, and with long postoperative stays in the ICU as well as if the underlying cause for wound problem is an infection.

Osteoporotic osseointegration: therapeutic hallmarks and engineering strategies

“…It is important to note that when developing fluid‒solid CFD simulations, the size of the fluid domain should match that of the trabecular specimen (e.g., a 3 × 3 × 3 mm bone specimen surrounded by a 3.4 × 3.4 × 3.4 mm fluid domain). The nature of bone marrow flow induced by negative pressure stimulation is characterized by its permeability 160 . Porosity is a commonly used parameter to predict the permeability of trabecular tissue.…”

Nutrition and Negative Pressure Wound Therapy: Improving Outcomes

“…Poor nutrition status has been shown to be a risk factor leading to longer courses of treatment. 3 Depending on the wound type and size, NPWT can incur significant fluid and protein losses which, if not replaced, can lead to depletion, further contributing to malnutrition and decreasing the ability to heal. 8 Poor nutrition status may contribute to impaired immunity leading to higher risk of infections at the wound site.…”

“…There are multiple benefits to wound healing seen with the use of these devices, including increased oxygenation of and blood flow to the wound bed; enhanced tissue epithelialization and granulation and reduced edema and bacterial colonization at the wound site. 3 The vacuum effect can also enhance wound contraction. 4…”