2024
DOI: 10.1002/bit.28658
|View full text |Cite
|
Sign up to set email alerts
|

Factors affecting product association as a mechanism of host‐cell protein persistence in bioprocessing

Young Hoon Oh,
Matthew L. Becker,
Kerri M. Mendola
et al.

Abstract: Product association of host‐cell proteins (HCPs) to monoclonal antibodies (mAbs) is widely regarded as a mechanism that can enable HCP persistence through multiple purification steps and even into the final drug substance. Discussion of this mechanism often implies that the existence or extent of persistence is directly related to the strength of binding but actual measurements of the binding affinity of such interactions remain sparse. Two separate avenues of investigation of HCP‐mAb binding are reported here… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Year Published

2025
2025
2025
2025

Publication Types

Select...
2

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
references
References 47 publications
0
0
0
Order By: Relevance