Background: Pelvic fractures are often associated with other injuries, and in our study, pelvic fractures associated with humeral fractures were the most common. We pooled patient data to analyze the independent risk factors for pelvic fractures associated with humeral fractures. Methods: A retrospective study was conducted on the clinical data of 254 patients with pelvic fractures admitted to the Department of Orthopedics of Chengdu Fifth People’s Hospital, from August 2017 to August 2021. Independent sample T test found that pelvic fractures combined with humeral fractures were statistically significant. The main outcome indicators of pelvic fracture combined with humeral fracture were as follows: Tile classification of pelvic fractures, number of humeral fractures and Injury Severity Scale (ISS); Secondary outcome indicators: gender, age, body mass index (BMI), cause of injury, underlying diseases, etc. Single factor analysis was performed to screen risk factors for each indicator, and logistic analysis was used to determine independent risk factors for indicators with P < 0.05. Results: Of the 254 patients with pelvic fractures, 24 (9.45%) were associated with humeral fractures, much higher than other single injuries, and only pelvic fractures associated with humeral fractures were statistically significant (P=0.014). Pelvic fractures without concomitant humeral fractures (n=230) and pelvic fractures with concomitant humeral fractures (n=24) were associated with age (P=0.006; 95% CI = 0.087-0.665; OR=10.258), ISS score (P=0.002; 95% CI = 1.839-4.445; OR=8.721), Tile scores (P=0.01; 95% CI = 22.554-87.419; OR=22.736), but there was no statistical significance in gender (P=1.03), BMI (P=0.437) and injury cause (P=3.04). Conclusion: The combination of pelvic fracture and humerus fracture was statistically significant, and age > 60 years old, pelvic fracture Tile B2 classification above and high ISS were the independent risk factors for humerus fracture in pelvic fracture. Therefore, in clinical work, when clinicians treat patients with pelvic fractures aged > 60 years old, Tile B2 type above classification of pelvic fractures and high ISS, they should be highly vigilant about whether the humerus fractures are accompanied.