Factors affecting survival after palliative radiotherapy in patients with lung cancer

Aires, F.; Rodrigues, Edna Aparecida Nico; Marques, Margarida; Pinto, Maria João

doi:10.5603/rpor.a2021.0079

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…Specifically, the risk regards common neoplastic conditions such as: endometrial [5,6], melanoma, kidney and female reproductive cancers [7][8][9][10][11]. Furthermore, their capacity to stimulate lung cancer, which is the most common human neoplastic condition [12][13][14], was implied. Here, at chronic use exceeding 5 years, or at high exposures of more than 540 defined daily doses per year, a moderately increased hazard occurred.…”

Section: Introductionmentioning

confidence: 99%

Impact of ramipril nitroso-metabolites on cancer incidence — in silico and in vitro safety evaluation

Regulska,

Kolenda,

Michalak

et al. 2023

Rep Pract Oncol Radiother.

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Background Angiotensin-converting enzyme inhibitors (ACE-I) and their pharmacologically related sartans have been associated with an increased cancer incidence in several clinical observations. In 2018, sartans were revealed as being significantly contaminated with nitrosamines. Nitrosamines are potent human mutagens that can be formed ex vivo and, more concerningly, also in vivo from nitrosatable drug precursors. Their formation in sartans may justify the reported cancer risk and, by analogy, this may also apply to ACE-Is. Materials and methods We investigated a commonly used ACE-I, ramipril (RAM). We checked its susceptibility to in vivo interaction with nitrite, potentially resulting in the generation of mutagenic N-nitrosamines. To that end, in silico simulation of mutagenicity of RAM nitroso-derivatives was performed using VEGA-GUI software. Then, the Nitrosation Assay Procedure was conducted which served as a model of endogenous reaction. The resulting post-nitrosation mixtures were subjected to a bacterial reverse mutation test employing Salmonella typhimurium strains TA98 and TA100 with and without metabolic activation. Results Our results showed that studied samples did not induce point mutations in the test bacteria, regardless of the catalytic cytochrome activity. Conclusion We concluded that RAM endogenous nitrosation is not the reason for increased cancer incidence. However, other ACE-Is must be verified in a similar manner.

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Section: Introductionmentioning

confidence: 99%

Impact of ramipril nitroso-metabolites on cancer incidence — in silico and in vitro safety evaluation

Regulska,

Kolenda,

Michalak

et al. 2023

Rep Pract Oncol Radiother.

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Development of brain metastases in patients managed with non-curative thoracic radiotherapy for stage II/III non-small cell lung cancer

Nieder,

Aanes,

Stanisavljevic

et al. 2024

Discov Onc

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Background This retrospective study analyzed the incidence of subsequent brain metastases after palliative radiotherapy or chemoradiation in patients with stage II/III non-small cell lung cancer (NSCLC). Risk factors for brain metastases development and survival after diagnosis were evaluated. Methods Different baseline parameters including but not limited to age, stage and target volume size were assessed. Outcomes were abstracted from electronic health records. Uni- and multivariate tests were performed. Results The study included 102 patients and found an actuarial risk of brain metastases of 15% (standard error ± 4) at one year and 20% (± 5) at two years. The maximum time interval was 15 months from start of radiation treatment. A non-significant survival difference was observed (median 12 months without versus 8.3 months with brain metastases, p = 0.21). Incidence was higher in patients with N2/3 stage, larger planning target volume size, and younger age (univariately significant factors). Trends were seen for stage III and adenocarcinoma histology. The multivariate analysis confirmed age as the most important risk factor. Conclusion The risk of brain metastases development was comparable to that reported in studies of curative chemoradiation. All events occurred within 15 months of follow-up, suggesting that long-term surveillance imaging may not be warranted. Patients younger than 60 years had a very high risk of brain metastases development.

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Factors affecting survival after palliative radiotherapy in patients with lung cancer

Cited by 2 publications

References 29 publications

Impact of ramipril nitroso-metabolites on cancer incidence — in silico and in vitro safety evaluation

Impact of ramipril nitroso-metabolites on cancer incidence — in silico and in vitro safety evaluation

Development of brain metastases in patients managed with non-curative thoracic radiotherapy for stage II/III non-small cell lung cancer

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