Factors affecting the morphology of benzoyl peroxide microsponges

Nokhodchi, Ali; Jelvehgari, Mitra; Siahi, M R; Mozafari, M. R.

doi:10.1016/j.micron.2007.06.012

Cited by 82 publications

(72 citation statements)

References 16 publications

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“…Vitamin D3 being an oil-soluble vitamin is very suitable and conveniently encapsulated by single O/W emulsion. A number of hydrophobic drugs were encapsulated successfully by using O/W method giving high production yield up to 97% as also reported by Nokhodchi [13]. However, being the hydrophilic nature of vitamin C, an encapsulation efficiency of around 56-59% is quite high as an encapsulation of hydrophilic drugs is quite challenging.…”

Section: Fig 1: Images Of Different Formulations Of Microsponges Taksupporting

confidence: 57%

“…Moreover, droplet coalescence may be another possible destabilizing mechanism responsible for the presence of a large particle. Here it is important to mention that too high PVA concentration can also have a negative impact on the particle size as reported by Nokhodchi et al [13] who obtained bigger microparticles when the concentration of PVA was higher. They justified that the increase in size can be attributed to an increase in apparent viscosity at increased emulsifier concentrations.…”

Section: Fig 1: Images Of Different Formulations Of Microsponges Takmentioning

confidence: 70%

“…PVA is a water-soluble non-ionic surfactant that is widely used as a stabilizer in the preparation of particles by avoiding the droplet coalescence during emulsification and subsequent solidification process [13,14]. It is evident from the results that increasing PVA concentration (F4 vs F5) did not significantly affected the mean microsponge size; however, there was a significant decrease in the size distribution of the microsponges.…”

Section: Fig 1: Images Of Different Formulations Of Microsponges Takmentioning

confidence: 91%

“…Distilled water was used for the preparation of solutions. [11][12][13][14][15]. The organic internal phase consisted of the certain amount of Eudragit ® RS 100 polymer dissolved in organic solvent (acetone or dichloromethane).…”

Section: Chemicalsmentioning

confidence: 99%

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Preparation of Ascorbic Acid and Cholecalciferol Microsponges for Topical Application

Zia

Nazir

Khan

et al. 2017

Int J Pharm Pharm Sci

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Objective: Apart from having various physiological functions in the body, ascorbic acid (vitamin C) and cholecalciferol (vitamin D3) also have a key role in skin protection. However, their bioavailability is quite limited in the skin, and therefore, many cosmetic products are supplemented with these vitamins, which are usually associated with stability issues. To avoid these issues, here we report on the preparation of microsponges of these vitamins for topical application. Methods:The microsponges were prepared through various emulsification-solvent evaporation methods involving singleThe organic internal phase was consisted of Eudragit ® RS 100 polymer dissolved in an organic solvent such as acetone or dichloromethane, at a constant polymer to drug ratio of 2:1. The prepared microsponges were characterized for their entrapment efficiency, droplet size and uniformity, core to wall interaction, and surface morphology.Results: It was found that the W/O/W and S/O/W are suitable methods for the preparation of vitamin C microsponges and O/W is a suitable method for the preparation of vitamin D3 microsponges; ensuring an encapsulation efficiency of around 56-59% and 93%, respectively. The average diameter of vitamin C and D3 microsponges was typically around 56-68 μm and 48 μm, respectively. Conclusion:It is possible to encapsulate both water and oil soluble vitamins in a microsponge system at an appreciable entrapment efficiency. The findings of the present study are expected to play a vital role in the development of cosmeceuticals.

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Section: Fig 1: Images Of Different Formulations Of Microsponges Taksupporting

confidence: 57%

Section: Fig 1: Images Of Different Formulations Of Microsponges Takmentioning

confidence: 70%

Section: Fig 1: Images Of Different Formulations Of Microsponges Takmentioning

confidence: 91%

Section: Chemicalsmentioning

confidence: 99%

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Preparation of Ascorbic Acid and Cholecalciferol Microsponges for Topical Application

Zia

Nazir

Khan

et al. 2017

Int J Pharm Pharm Sci

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“…A single nanosponge system consists of a myriad of interconnecting voids within a non-collapsible structure capable of holding a wide variety of substances. The outer surface is typically porous, allowing a sustained flow of substances out of the particle (18). These nano-sized colloidal carriers have been recently proposed for drug delivery, since their use can solubilize poorly water-soluble drugs and provide prolonged release, as well as improve the drug's bioavailability by modifying the pharmacokinetic parameters of actives (19).…”

mentioning

confidence: 99%

Cyclodextrin based nanosponges for pharmaceutical use: A review

Tejashri¹,

Amrita²,

Darshana³

2013

Acta Pharmaceutica

197

100

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Nanosponges are a novel class of hyper-crosslinked polymer based colloidal structures consisting of solid nanoparticles with colloidal sizes and nanosized cavities. Well--known examples of nanosponges are titanium-based nanosponges (1), silicon nano- Nanosponges are a novel class of hyper-crosslinked polymer based colloidal structures consisting of solid nanoparticles with colloidal sizes and nanosized cavities. These nano-sized colloidal carriers have been recently developed and proposed for drug delivery, since their use can solubilize poorly water-soluble drugs and provide prolonged release as well as improve a drug's bioavailability by modifying the pharmacokinetic parameters of actives. Development of nanosponges as drug delivery systems, with special reference to cyclodextrin based nanosponges, is presented in this article. In the current review, attempts have been made to illustrate the features of cyclodextrin based nanosponges and their applications in pharmaceutical formulations. Special emphasis has been placed on discussing the methods of preparation, characterization techniques and applications of these novel drug delivery carriers for therapeutic purposes. Nanosponges can be referred to as solid porous particles having a capacity to load drugs and other actives into their nanocavity; they can be formulated as oral, parenteral, topical or inhalation dosage forms. Nanosponges offer high drug loading compared to other nanocarriers and are thus suitable for solving issues related to stability, solubility and delayed release of actives. Controlled release of the loaded actives and solubility enhancement of poorly water-soluble drugs are major advantages of nanosponge drug delivery systems.

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Cyclodextrin‐based nanosponges as promising carriers for active pharmaceutical ingredient

Jawaharlal,

Subramanian,

Palanivel

et al. 2023

J Biochem & Molecular Tox

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Effective drug distribution at the intended or particular location is a critical issue that researchers are now dealing. Nanosponges have significantly increased in importance in medication delivery using nanotechnology in recent years. An important step toward solving these problems has been the development of nanosponges. Recently created and proposed for use in drug delivery, nanosponge is a unique type of hyper‐crosslinked polymer‐based colloidal structures made up of solid nanoparticles with colloidal carriers. Nanosponges are solid porous particles that may hold pharmaceuticals and other actives in their nanocavities. They can be made into dosage forms for oral, parenteral, topical, or inhalation use. The targeted distribution of drugs in a regulated manner is greatly aided by nanosponge. The utilization of nanosponges, their benefits, their production processes, the polymers they are made of, and their characterization have all been covered in this review article.

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Factors affecting the morphology of benzoyl peroxide microsponges

Cited by 82 publications

References 16 publications

Preparation of Ascorbic Acid and Cholecalciferol Microsponges for Topical Application

Preparation of Ascorbic Acid and Cholecalciferol Microsponges for Topical Application

Cyclodextrin based nanosponges for pharmaceutical use: A review

Cyclodextrin‐based nanosponges as promising carriers for active pharmaceutical ingredient

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