Factors Affecting the Occurrence of Urothelial Tumors in Dye Workers Exposed to Aromatic Mines

Sendo, Toshiaki; Miyai, Masahiro; Sawada, Yoshihisa; Inagaki, Takeshi; Okawa, Toru

doi:10.1111/j.1442-2042.1995.tb00465.x

Cited by 39 publications

(20 citation statements)

References 3 publications

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“…[41][42][43][44] Second, exposure to benzidine and other arylamines has been associated with increased risks of bladder cancer in both Asian and Caucasian workers. 17,[45][46][47][48][49][50] Third, as shown in the metaanalysis presented in Table III of Asian populations not exposed to arylamines in the workplace, studies have shown that slow acetylation is a risk factor for bladder cancer comparable to the risk found in Caucasian populations, and the magnitude of the relative risk is the same. 3 Fourth, even though racial differences in the allele distribution among different ethnic groups have been reported, almost all of the alleles found in Caucasian groups have been described in Asian populations.…”

Section: Discussionmentioning

confidence: 93%

NAT2 slow acetylation and bladder cancer in workers exposed to benzidine

Carreón

Ruder

Schulte

et al. 2005

Intl Journal of Cancer

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This study expands a previous study of NAT2 polymorphisms and bladder cancer in male subjects occupationally exposed only to benzidine. The combined analysis of 68 cases and 107 controls from a cohort of production workers in China exposed to benzidine included 30 new cases and 67 controls not previously studied. NAT2 enzymatic activity phenotype was characterized by measuring urinary caffeine metabolite ratios. PCR-based methods identified genotypes for NAT2, NAT1 and GSTM1. NAT2 phenotype and genotype data were consistent. A protective association was observed for the slow NAT2 genotype (bladder cancer OR = 0.3; 95% CI = 0.1 = 1.0) after adjustment for cumulative benzidine exposure and lifetime smoking. Individuals carrying NAT1wt/*10 and NAT1*10/*10 showed higher relative risks of bladder cancer (OR = 2.8, 95% CI = 0.8-10.1 and OR = 2.2, 95% CI = 0.6-8.3, respectively). No association was found between GSTM1 null and bladder cancer. A metaanalysis risk estimate of case-control studies of NAT2 acetylation and bladder cancer in Asian populations without occupational arylamine exposures showed an increased risk for slow acetylators. The lower limit of the confidence interval (OR = 1.4; 95% CI = 1.0-2.0) approximated the upper confidence interval for the estimate obtained in our analysis. These results support the earlier finding of a protective association between slow acetylation and bladder cancer in benzidine-exposed workers, in contrast to its established link as a risk factor for bladder cancer in people exposed to 2-naphthylamine and 4-aminobiphenyl. Study findings suggest the existence of key differences in the metabolism of mono- and diarylamines.

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Section: Discussionmentioning

confidence: 93%

NAT2 slow acetylation and bladder cancer in workers exposed to benzidine

Carreón

Ruder

Schulte

et al. 2005

Intl Journal of Cancer

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“…These aromatic hydrocarbons have been and are used in many industries (dyes, textiles, rubber, chemicals, petrochemicals, coal) and research. Aromatic amines are responsible for the carcinogenicity of certain chemicals, including benzidine and β‐naphtylanine [1,11]. These two pathogens have been phased out since 1960 and were eventually banned in most industrialized countries.…”

Section: Occupation‐related Uut‐uccmentioning

confidence: 99%

“…The estimated risk (OR) of developing TCC when exposed to aromatic amines is 8.3 according to Shinka et al . [11].…”

Section: Occupation‐related Uut‐uccmentioning

confidence: 99%

Environmental factors involved in carcinogenesis of urothelial cell carcinomas of the upper urinary tract

Colin¹,

Koenig²,

Ouzzane³

et al. 2009

BJU International

256

151

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Primary cancers of the ureter and renal pelvis are rare tumours, >90% of which are transitional cell carcinomas. Only ≈5% of urothelial tumours arise in the upper urinary tract (UUT). Many environmental factors contribute to the development of these cancers. Some are similar to bladder cancer‐associated factors (tobacco, occupational exposure), while others are more specific to carcinogenesis of the UUT (phenacetine, Balkan endemic nephropathy [BEN], Chinese herb nephropathy or association with Blackfoot disease [BFD]). This review discusses the environmental factors involved in UUT carcinoma. Tobacco and occupational exposure remain the principal exogenous risk factors for developing these tumours. Conversely, carcinogenesis of UUT tumours resulting from phenacetine consumption has almost disappeared. Although the incidence of BEN is also on the decline, roles for aristolochic acid and the consumption of Chinese herbs in the physiopathology and induction of this nephropathy, respectively, have proposed. In Taiwan, the association of this tumour type with BFD and arsenic exposure remains unclear to date. As some genetic polymorphisms are associated with an increased risk of cancer or faster disease progression, there is variability in interindividual susceptibility to the development of UUT carcinoma when exposed to the aforementioned risk factors Cytosolic sulfotransferases (SULTs) catalyse the detoxification of many environmental chemicals but also in the bioactivation of dietary and other mutagens. Polymorphism of the SULT gene, is thought to confer susceptibility to upper tract tumours.

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“…On the other hand, UTUCs are relatively uncommon and account for only 5 to 10 % of all urothelial carcinomas [3]. The etiology of all UCs, from both anatomical locations, share common carcinogens, including tobacco and aromatic amines, such as benzidine and β-naphtylanine [4][5][6]. It is true that some contributory factors, however, show a stronger impact on UTUC than on UBUC; for example, patients with endemic Balkans nephropathy [7,8], Chinese herb nephropathy [8,9], and analgesic nephropathy [10] are more susceptible to UTUC than UBUC.…”

Section: Introductionmentioning

confidence: 99%

HAS3 underexpression as an indicator of poor prognosis in patients with urothelial carcinoma of the upper urinary tract and urinary bladder

Chang

Liang

et al. 2015

Tumor Biol.

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Via data mining a published transcriptomic database of UBUC (GSE31684), we discovered hyaluronan synthase-3 (HAS3) as the most significant gene stepwise downregulated from early tumorigenesis to progression among those associated with hyaluronan synthase activity (GO:0050501). We consequently analyzed HAS3 protein expression and their association with clinicopathological factors and survival in our well-characterized cohort of urothelial carcinoma of upper urinary tract (UTUC) and urinary bladder (UBUC). HAS3 expression was assessed by immunohistochemistry and evaluated by using H score method in 295 UBUCs and 340 UTUCs, respectively. HAS3 protein expression statuses were further correlated with clinicopathological parameters and evaluated the prognostic significance for disease-specific survival (DSS) and metastasis-free survival (MeFS). HAS3 protein underexpression was significantly associated with advanced pT status, nodal metastasis, high histological grade, vascular invasion, and frequent mitoses in both groups of UCs. HAS3 underexpression not only predicted poorer DSS and MeFS with univariate analysis, but also indicated dismal DSS and MeFS in multivariate analysis. HAS3 underexpression is associated with advanced tumor stage and adverse pathological features, as well as implies inferior clinical outcomes for both groups of patients with UTUCs and UBUCs, suggesting its critical role in tumor progression in UCs and may serve as a prospective prognostic biomarker and a novel therapeutic target in UCs.

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Factors Affecting the Occurrence of Urothelial Tumors in Dye Workers Exposed to Aromatic Mines

Cited by 39 publications

References 3 publications

NAT2 slow acetylation and bladder cancer in workers exposed to benzidine

NAT2 slow acetylation and bladder cancer in workers exposed to benzidine

Environmental factors involved in carcinogenesis of urothelial cell carcinomas of the upper urinary tract

HAS3 underexpression as an indicator of poor prognosis in patients with urothelial carcinoma of the upper urinary tract and urinary bladder

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