Factors affecting the variation in antibiotic resistance of Helicobacter pylori over a 3-year period

Ferrero, Miguel Pérez; Ducons, J; Sicilia, Beatriz; Santolaria, Santos; Sierra, E.; Gomollón, Fernando

doi:10.1016/s0924-8579(00)00205-3

Cited by 21 publications

(18 citation statements)

References 15 publications

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“…In contrast to clarithromycin, the mechanisms of resistance to metronidazole in H. pylori are less clear and susceptibility tests to metronidazole have sometimes been found problematic. In many studies, like in ours, the E ‐test has been the method used 12–15, 23–26 . However, it has been criticized for discrepancy and inter‐laboratory variation in results and higher rates of metronidazole resistance as compared to the agar dilution method 27, 28 .…”

Section: Discussionmentioning

confidence: 92%

Primary Helicobacter pylori resistance to metronidazole and clarithromycin in the Finnish population

Koivisto

Rautelin

Voutilainen

et al. 2004

Aliment Pharmacol Ther

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SUMMARYAim: To systematically determine Helicobacter pylori primary antimicrobial resistance in Finland and the associated demographic and clinical features. Methods: A total of 342 adult patients referred for gastroscopy at 23 centres in different parts of Finland and positive for the rapid biopsy urease test were recruited. Clinical and demographic data were collected via a structured questionnaire. Patients with positive H. pylori culture and successful antibiotic sensitivity determination by the E-test method (n ¼ 292) were included in the present analysis. Results: The study population consisted of 134 men and 158 women, mean age 56 years (95% CI, 55-58 years). Resistance to metronidazole was 38% (110 of 292) and to clarithromycin 2% (seven of 292). Resistance to metronidazole was higher in women than in men (48% vs. 25%, P < 0.001).Previous use of antibiotics for gynaecological infections predicted metronidazole resistance (P ¼ 0.01), and previous use of antibiotics for respiratory (P ¼ 0.02) and dental infections (P ¼ 0.02) the clarithromycin resistance. We observed no major geographical variations in metronidazole resistance. Conclusions: The primary metronidazole resistance of H. pylori was 38% and was common in women previously treated for gynaecological infections. Primary clarithromycin resistance was uncommon (2%) and may associate with previous dental and respiratory infections.

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Section: Discussionmentioning

confidence: 92%

Primary Helicobacter pylori resistance to metronidazole and clarithromycin in the Finnish population

Koivisto

Rautelin

Voutilainen

et al. 2004

Aliment Pharmacol Ther

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“…Therefore, we lack information about clarithromycin resistance in our patients. However, resistance to this antibiotic in our area is around 10% and has remained stable in recent years (29)(30)(31)(32)(33). These values seem quite similar to those observed in U.S. recent studies with triple therapy (19).…”

Section: Discussionmentioning

confidence: 99%

Seven versus Ten Days of Rabeprazole Triple Therapy for Helicobacter pylori Eradication: A Multicenter Randomized Trial

Calvet

Ducons²,

Bujanda³

et al. 2005

Am J Gastroenterology

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“…Boyanova et al [27] examined the frequencies of resistant strains isolated in Bulgaria over 4 years. Ferrero et al [28] examined resistant strains isolated in Spain over 3 years. Both studies showed an increase in resistant strains over time.…”

Section: Discussionmentioning

confidence: 99%

Characteristics and Trends of Clarithromycin-Resistant <i>Helicobacter pylori</i> Isolates in Japan over a Decade

et al. 2004

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Clarithromycin has been administered to patients in Japan since 1991. Clarithromycin-resistant Helicobacter pylori strains have been on the rise in Japan. We obtained H. pylori isolates between 1989 and 2000 and examined mutations of the 23S rRNA gene, which are closely associated with clarithromycin resistance. Isolates were obtained from 356 patients with H. pylori infection treated at the Hiroshima University. Sixty-one of the patients received clarithromycin-based H. pylori eradication therapy. Mutations of the 23S rRNA gene were examined by polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) followed by sequencing analysis. Mutant strains were found in 42 of the 356 patients (11.8%). The prevalence of mutant strains increased from 0 to 20.4% during the 12-year study period. The prevalence increased to more than 10% by 1995 and then to more 20% after 1999. The H. pylori eradication rate was significantly higher in patients with wild-type strains than in patients with mutant strains (72.0 vs. 36.4%, p = 0.024). Our data indicate that clarithromycin-resistant H. pylori strains have increased rapidly since 1995 and that the effectiveness of clarithromycin-based H. pylori eradication therapies may soon be compromised. Other new therapies may be necessary as first-line treatments in Japan.

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Factors affecting the variation in antibiotic resistance of Helicobacter pylori over a 3-year period

Cited by 21 publications

References 15 publications

Primary Helicobacter pylori resistance to metronidazole and clarithromycin in the Finnish population

Primary Helicobacter pylori resistance to metronidazole and clarithromycin in the Finnish population

Seven versus Ten Days of Rabeprazole Triple Therapy for Helicobacter pylori Eradication: A Multicenter Randomized Trial

Characteristics and Trends of Clarithromycin-Resistant <i>Helicobacter pylori</i> Isolates in Japan over a Decade

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