Purpose: This paper adds to the literature on female entrepreneurship in the Algarve region in Portugal. We obtained data on the profile, motivations and difficulties experienced by female entrepreneurs and studied the effects of the Covid-19 pandemic crisis on their ventures.Design/methodology/approach: The research resorted to a Case Study approach, along with semi-structured interviews with twenty-four women who create and develop their activity in Algarve.Findings: It was concluded that the presence of entrepreneurs in the family, the influence of networking, and knowledge and professional experience were relevant factors for their entrepreneurial initiative and behaviour. The main constraints identified were: insecurity and difficulties in hiring staff. Regarding the motivations of female entrepreneurs, the need for independence and personal fulfilment stand out, reflecting a predominance of entrepreneurial activity based on the identification of opportunities. The negative impact of the pandemic on the business development of the interviewees, although mitigated by digital tools, was felt globally.Originality/value: As the literature review established, despite being a well-known tourist destination internationally, the Algarve region remains overlooked, especially when it comes to the study and analysis of social and economic dynamics. In the same vein, so has the study of female entrepreneurship in the region. The methodology used in this paper allowed for the creation of a survey that provides new empirical information.