Factors and Strategies for Post-Vertebroplasty Residual Pain from Thoracolumbar Osteoporotic Vertebral Compression Fractures (OVCF): a systematic review.

Abstract

Purpose Insignificant pain relief (IPR) in short period after vertebroplasty is common, which often disturb doctors and affect patients Therefore, we reviewed systematically relative articles and attempted to get meaningful evidence on factors and strategies for IPR.Methods PubMed, Web of Science, Embase, CNKI, WanFang, and VIP were searched for literatures treating the osteoporotic vertebral compression fractures (OVCFs) with vertebroplasty and assessing the clinical efficacy.Results 817 references were electronically retrieved, 81 full-text papers were screened and 41 studies were included. Twenty-two trials presented factors on IPR, mainly including bone cement related, operation related and patient-related factors. Nineteen studies showed strategies on residual pain, including improving osteoporosis, reforming surgical operation and add other therapies. 16 prospective, 20 retrospective and 5 meta-analyses consisted the systematic review. The date from included studies point to different results, with less risk of bias, were needed to clarify the factors and strategies for residual pain.Conclusions Bone cement distribution and operation error are highly related to the post-vertebroplasty residual pain. Many therapeutic methods could improve pain and rehabilitate function but lacking more high-level evidence due to the insufficient trails.