Factors associated to lifestyle and risk of adult onset asthma

Huovinen, Elisa; Kaprio, Jaakko; Koskenvuo, Markku

doi:10.1053/rmed.2003.1419

Cited by 144 publications

(131 citation statements)

References 37 publications

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“…Our results on the BMI-derived obesity and asthma association are consistent with previous prospective studies, which found that BMI had a strong dose-response relationship with asthma development [6,17,[25][26][27][28][29][30]. In a meta-analysis study, BEUTHER and SUTHERLAND [6] analysed seven prospective studies (n5333,102) evaluating BMI and incident asthma.…”

Section: Discussionsupporting

confidence: 90%

“…Even though the detailed health survey allowed us to examine a large range of baseline characteristics, residual confounding from unknown characteristics may have limited our study. Dietary constituents may affect both obesity and incident asthma [28,36], and this could not be evaluated in our study. Obesity has also been suggested to increase the risk of asthma through comorbidities [32], for example, GORD and SDB are important risk factors for asthma in obese people.…”

Section: Discussionmentioning

confidence: 98%

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General and abdominal obesity and incident asthma in adults: the HUNT study

et al. 2012

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Measures of body mass index (BMI) and waist circumference define general obesity and abdominal obesity respectively. While high BMI has been established as a risk factor for asthma in adults, waist circumference has seldom been investigated.To determine the association between BMI, waist circumference and incident asthma in adults, we conducted a prospective study (n523,245) in a population living in Nord-Trøndelag, Norway in 1995 Baseline BMI and waist circumference were measured and categorised as general obesity (BMI o30.0 kg?m 2 ) and abdominal obesity (waist circumference o88 cm in females and o102 cm in males). Incident asthma was self-reported new-onset cases during an 11-yr follow-up period. Odds ratios for asthma associated with obesity were calculated using multivariable logistic regression.General obesity was a risk factor for asthma in females (OR 1.96, 95% CI 1.52-2.52) and males (OR 1.84, 95% CI 1.30-2.59). In females, after additional adjustment for BMI, abdominal obesity remained a risk factor for asthma development (OR 1.46, 95% CI 1.04-2.05). Abdominal obesity seems to increase the risk of incident asthma in females in addition to BMI, indicating that using both measures of BMI and waist circumference in females may be a superior clinical assessment for asthma risk than any measure alone.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 98%

General and abdominal obesity and incident asthma in adults: the HUNT study

et al. 2012

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“…The effects of overweight and obesity on asthma hold when the analysis is done separately for women aged 15À29 and 30À49 y. These findings are consistent with other growing evidence, some from prospective cohort studies, [10][11][12][13][14][15][16][17][18][19][25][26][27][28] and provide further evidence, from a developing-country setting, that obesity may increase the risk of asthma in adult women. Underweight women have a significantly higher risk of asthma than women with a normal BMI, consistent with greater vulnerability of undernourished women in developing countries to a host of other diseases.…”

Section: Discussionsupporting

confidence: 87%

“…[42][43][44] To the extent this occurs, the estimated effect of obesity on asthma may be overestimated. However, given that several prospective cohort studies have linked obesity and weight gain to the onset of asthma both in adults 25,26 and children, 27,28 the causation is likely to be primarily from obesity to asthma. There is clearly need for prospective cohort studies of obesity and asthma in developing countries.…”

Section: Discussionmentioning

confidence: 99%

“…25 Another recent prospective study of 10 597 adult twins in Finland followed for 9 y has found obesity to be associated with the risk of adult-onset asthma. 26 Convincing evidence of obesity causing asthma onset is also provided by at least two prospective cohort studies of children. The Growing Up Today study of 16 862 children found that BMI has a positive, independent risk of incident asthma in both boys and girls, concluding that increasing prevalence of obesity may partly explain the rising asthma prevalence in children.…”

Section: Introductionmentioning

confidence: 99%

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Effect of obesity on asthma among adult Indian women

Mishra

2004

Int J Obes

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OBJECTIVE: Both obesity and asthma are on the rise worldwide. This study examined the association between obesity and asthma prevalence in adult women in India. METHODS: The analysis used information on 82 464 nonpregnant, ever-married women aged 15À49 y, included in India's 1998À99 National Family Health Survey. The effects of measured Body Mass Index (BMI) on reported asthma were estimated using logistic regression, after adjusting for tobacco smoking (active and passive), cooking smoke, age, education, work status, media habits, food habits, house type, separate kitchen, indoor crowding, religion, caste/tribe, household living standard, urban/rural residence, and geographic region. RESULTS: Obese women (BMIZ30.0 kg/m 2 ) were about twice as likely as those with a normal BMI (18.5À25.0 kg/m 2 ) to report suffering from asthma (OR ¼ 1.92; 95% CI: 1.40À2.65). The association between obesity and asthma remained strong and statistically significant even when the effects of other selected risk factors and potential confounders were controlled (OR ¼ 1.85; 95% CI: 1.30À2.63). Overweight women (25.0rBMIo30.0 kg/m 2 ) also reported significantly higher adjusted asthma prevalence than those with a normal BMI (OR ¼ 1.32; 95% CI: 1.07À1.63). Results hold in separate analysis for younger (15À29 y) and older (30À49 y) women. CONCLUSION: The study finds a strong positive association between obesity and asthma among adult Indian women. To validate this relationship and to establish causality, prospective epidemiological studies, with better measures of overweight conditions and clinical measures of asthma, are needed in developing-country settings.

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Different effects of smoking on atopic and non‐atopic adult‐onset asthma

Lajunen

Jaakkola

2021

Clinical & Translational All

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Background Both tobacco smoking and atopy increase the risk of adult‐onset asthma. We studied if there are differences in the effects of smoking on the risks of atopic and non‐atopic adult‐onset asthma, and if gender modifies these effects. Methods The Finnish Environment and Asthma Study (FEAS) includes 521 incident cases of adult‐onset asthma and 932 population‐based controls, aged 21 to 63 years, recruited from a geographically defined area of Pirkanmaa, South Finland. Asthma was defined based on symptoms and lung function measurements, atopy by IgE antibodies to common aeroallergens and smoking by the study questionnaire. Results Altogether 212 cases were atopic, and 251 cases were non‐atopic. Regular smoking increased the risk of atopic asthma (adjusted OR 1.24, 95% CI 0.83–1.85), this effect was seen in women (aOR 1.77, 1.06–2.95) but not in men (aOR 0.75, 0.39–1.45). Among regular smokers, the amount smoked was lowest among women with atopic asthma. Recent quitting of smoking was related to increased risk of both atopic (aOR 4.91, 2.26–10.65) and non‐atopic (aOR 4.37, 1.87–10.21) asthma. Having quitted smoking over a year ago was related to increased risk of non‐atopic asthma (aOR 1.57, 1.08–2.28), mainly in men (aOR 2.03, 1.06–3.88). Conclusions In women, rather small amounts of regular smoking increase the risk of atopic asthma. However, for non‐atopic asthma, the smoking induced risk continues for longer after quitting, especially in men. In conclusion, the effects of smoking on the risks of atopic and non‐atopic asthma differ, and gender modifies these effects.

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Factors associated to lifestyle and risk of adult onset asthma

Abstract: Obesity was associated to the risk of adult onset asthma, while short height and low leisure time physical activity can be considered as other potential risk factors.

Cited by 144 publications

References 37 publications

General and abdominal obesity and incident asthma in adults: the HUNT study

General and abdominal obesity and incident asthma in adults: the HUNT study

Effect of obesity on asthma among adult Indian women

Different effects of smoking on atopic and non‐atopic adult‐onset asthma

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