Factors Associated with Acquisition and Clearance of Human Papillomavirus Infection in a Cohort of US Men: A Prospective Study

Lu, Binfeng; Wu, Yougui; Nielson, Carrie M.; Flores, Roberto; Abrahamsen, Martha; Papenfuss, Mary; Harris, Robin B.; Giuliano, Anna

doi:10.1086/596050

Cited by 115 publications

(113 citation statements)

References 42 publications

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“…Several other studies also associated past sexual behavior with HPV incidence. 14,16,[40][41][42] Generally, one would expect past sexual behavior to be related to HPV prevalence (as shown before by our group) but not to HPV incidence. 28 A possible explanation could be that women with a high number of sexual partners in the past may potentially date men who also have a high number of sexual partners in the past, a group likely to have a higher HPV prevalence, and therefore increase the risk of acquiring HPV.…”

Section: Incidencementioning

confidence: 65%

Prospective follow‐up of 2,065 young unscreened women to study human papillomavirus incidence and clearance

Schmeink

Massuger

Lenselink

et al. 2013

Intl Journal of Cancer

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Human papillomavirus (HPV) is a necessary factor in the development of cervical intraepithelial neoplasia and cervical cancer. However, HPV is also a very common sexually transmitted virus and many women clear their infection. To study HPV incidence and clearance, 2,065 women, aged 18-29 years, were followed for 12 months and were asked to provide a self-collected cervicovaginal sample and fill-out a questionnaire every 3 months. For HPV DNA detection, the SPF 10 -DEIA LiPA 25 system was used. Incidence rates of any-type high-risk HPV and low-risk HPV were 17.0 per 1,000-person months, and 14.3 per 1,000-person months, respectively. HPV types 16, 52, 51 and 31 had the highest type-specific incidence rates. HPV incidence was increased in singles, and women having a new relationship. A higher number of lifetime sex partners, and a higher frequency of sexual contacts in the past 3 months was associated with an increased HPV incidence. The overall clearance of the newly detected typespecific high-risk HPV infections and low-risk HPV infections was 61.2% and 69.0%, respectively. Having a sexual relationship compared to being single, and a higher sexual age both positively influenced the clearance of any-type high-risk HPV. Among the women infected with HPV 16, the women who had a co-infection had a lower proportion of clearance of HPV 16. In conclusion, in this young Dutch study population, HPV incidence rates are not related to age and comparable to other western countries. Clearance was only independently related to factors associated with sexual behavior, either past or current.It is generally accepted that a persistent human papillomavirus (HPV) infection is the necessary cause of cervical cancer. Acquisition of an HPV infection is therefore the main precursor of the series of events that eventually lead to cervical cancer.1-4 Fortunately, most of the acquired HPV infections are transient and clear spontaneously within 12 months after first detection, and about 90% of the women will have cleared their HPV infection within 24 months. [5][6][7][8][9][10][11][12][13] HPV is a very common sexually transmitted virus, mainly acquired early in sexual life.14,15 Rates of acquiring an HPV infection are high following first sexual intercourse, and with each new sexual partner. 7,16,17 The risk factors associated with acquiring an HPV infection are therefore mainly related to the individuals sexual behavior. 18HPV prevalence, however, is not only influenced by sexual activity but also varies by age and geography, as shown by the International Agency for Research on Cancer (IARC) and others. [19][20][21] Young women have high rates of HPV acquisition, and incidence tends to decline with age. 10,17,22,23 Whether age is also related to the duration of the infection remains controversial. Some studies report that there is no influence of age on the clearance rate of the HPV infection. 10,24,25 Whereas other studies report a lower clearance rate with increasing age, 26,27 or in contrary a faster clearance rate in older women (>4...

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Section: Incidencementioning

confidence: 65%

Prospective follow‐up of 2,065 young unscreened women to study human papillomavirus incidence and clearance

Schmeink

Massuger

Lenselink

et al. 2013

Intl Journal of Cancer

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“…Details of this cohort have been previously reported (12,13). In brief, 337 men (89.4% of eligible men screened) ages 18 to 44 years were enrolled.…”

Section: Study Populationmentioning

confidence: 99%

Epidemiologic Factors Associated with Seropositivity to Human Papillomavirus Type 16 and 18 Virus–Like Particles and Risk of Subsequent Infection in Men

Hagensee

Lee

et al. 2010

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Our understanding of humoral response to human papillomavirus (HPV) infection has been mainly derived from studies in women. The role of serum antibodies in the natural history of HPV in men has yet to be investigated. Data from 285 male participants of a natural history study were used to determine the epidemiologic factors associated with HPV 16/18 seropositivity and explore the role of HPV 16 and 18 serum antibodies in subsequent HPV infections. Serum antibodies were detected by use of HPV 16-and 18 virus-like particles enzyme-linked immunoassay. Logistic regression and Generalized Estimating Equation was used for the evaluation of risk factors. The risk of subsequent HPV infection by baseline antibody status was assessed by incidence rate ratio and its confidence intervals. Men ages 36 to 44 years compared with men ages 18 to 25 years were four times more likely to be seropositive to HPV 16/18. In addition, being divorced, separated, or widowed; being a former smoker; and having sex with men was positively and independently associated with HPV 16/18 seropositivity. Our findings on the potential role of HPV 16 or 18 serum antibodies in subsequent infection were inconclusive. Large prospective studies are warranted to adequately address questions on the role of natural immunity in the natural history of HPV infections in men. Cancer Epidemiol Biomarkers Prev; 19(2); 511-6. ©2010 AACR.

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“…(24)(25)(26) In Lu et al, men reporting ≥ 16 lifetime sex partners compared to those with zero to four lifetime partners, had an elevated risk of any HPV infection (adjusted hazard ratio [AHR]=2.8; 95% CI: 1.1-7.1), of oncogenic HPV infection (AHR=9.6; 95% CI: 2.4-37.8), and non-oncogenic HPV infection (AHR=3.6; 95% CI: 1.3-9.9). A significant protective effect associated with circumcision is reliably reported in the literature.…”

Section: Risk Factors For Hpv In Malesmentioning

confidence: 99%

Update on Human Papillomavirus (HPV) Vaccines

Dm¹,

Mt²,

Ds³

2012

Canada Communicable Disease Report

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Factors Associated with Acquisition and Clearance of Human Papillomavirus Infection in a Cohort of US Men: A Prospective Study

Abstract: The key factor associated with acquisition of HPV was lifetime number of sex partners, whereas circumcision was the most significant determinant for clearance of any HPV infection and oncogenic HPV infection.

Cited by 115 publications

References 42 publications

Prospective follow‐up of 2,065 young unscreened women to study human papillomavirus incidence and clearance

Prospective follow‐up of 2,065 young unscreened women to study human papillomavirus incidence and clearance

Epidemiologic Factors Associated with Seropositivity to Human Papillomavirus Type 16 and 18 Virus–Like Particles and Risk of Subsequent Infection in Men

Update on Human Papillomavirus (HPV) Vaccines

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