Factors Associated with Affective Symptoms and Quality of Life in Patients with Atopic Dermatitis

Ferrucci, Silvia; Tavecchio, Simona; Angileri, Luisa; Surace, Teresa; Berti, Emilio; Buoli, Massimiliano

doi:10.2340/00015555-3922

Cited by 20 publications

(18 citation statements)

References 56 publications

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“…Scoring from each item ranges from 0 to 3, thus the total score for each subscale can range from 0 to 21. A score > 7 in each subscale denotes the presence of clinically significant anxiety and depression 53 . The questionnaire was validated in Italian 54 .…”

Section: Methodsmentioning

confidence: 99%

Women’s quality of sleep and in vitro fertilization success

Reschini

Buoli

Facchin

et al. 2022

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Women undergoing in vitro fertilization (IVF) are emotionally challenged. Anxiety, depression, and sleep disturbances are common complaints. The impact of these symptoms on IVF outcome is however debated. In this study, we aimed at investigating whether sleep quality and psychological health can affect the chances of success of the procedure. Women undergoing IVF were recruited at the time of oocytes retrieval. Women’s sleep quality and psychological health was assessed using the Pittsburgh Sleep Quality Index (PSQI), the Fertility Problem Inventory (FPI), and the Hospital Anxiety and Depression Scale (HADS). Baseline characteristics and results of the three scales were compared between women who did and did not succeed. Overall, 263 women were included, of whom 81 had a clinical pregnancy (31%). As expected, successful women were younger, and their ovarian reserve was more preserved. FPI and HADS scores did not differ. Conversely, a statistically significant difference emerged for the PSQI score, the median [interquartile range] in pregnant and non-pregnant women being 4 [3–5] and 5 [3–7], respectively (p = 0.004). The crude and adjusted OR of pregnancy in women with a PSQI > 5 (indicating impaired sleep quality) was 0.46 (95% CI 0.25–0.86, p = 0.02) and 0.50 (95% CI: 0.26–0.94, p = 0.03), respectively. In conclusion, low sleep quality is common in women scheduled for IVF and could influence the success of the procedure.

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Section: Methodsmentioning

confidence: 99%

Women’s quality of sleep and in vitro fertilization success

Reschini

Buoli

Facchin

et al. 2022

Sci Rep

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“… 31 A recent study reported that previous treatment with systemic immunosuppressants, more severe depressive symptoms, itch, impaired sleep, and perceived severity of dermatological symptoms were significant predictors of poor quality of life. 32 Patients with AD have been found to exhibit inferior social functioning and mental health scores compared with the general population. Greater disease severity is associated with poorer quality of life and health-related quality of life, especially in children.…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics of Atopic Dermatitis in Korean School-Aged Children and Adolescents According to Onset Age and Severity

et al. 2022

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Background Atopic dermatitis (AD) is a heterogeneous disease with different age of onset, disease course, clinical symptoms, severity, and risk of comorbidity. The characteristics of children with AD also vary by age or country. However, little is known about the clinical characteristics of AD in Korean school-aged children and adolescents. Furthermore, there are few studies on phenotypic differences according to onset age. This study aimed to explore the clinical characteristics and phenotypes according to onset age and severity of AD in children and adolescents in Korea. Methods AD patients aged 6–18 years who presented to 18 hospitals nationwide were surveyed. The patients were examined for disease severity by pediatric allergy specialists, and data on history of other allergic diseases, familial allergy history, onset age, trigger factors, lesion sites, treatment history and quality of life were collected. The results of the patient’s allergy test were also analyzed. The patients were classified into infancy-onset (< 2 years of age), preschool-onset (2–5 years of age), and childhood-onset (≥ 6 years of age) groups. Study population was analyzed for clinical features according to onset-age groups and severity groups. Results A total of 258 patients with a mean age of 10.62 ± 3.18 years were included in the study. Infancy-onset group accounted for about 60% of all patients and presented significantly more other allergic diseases, such as allergic rhinitis and asthma ( P = 0.002 and P = 0.001, respectively). Food allergy symptoms and diagnoses were highly relevant to both earlier onset and more severe group. Inhalant allergen sensitization was significantly associated with both infancy-onset group and severe group ( P = 0.012 and P = 0.024, respectively). A family history of food allergies was significantly associated with infancy-onset group ( P = 0.036). Severe group was significantly associated with a family history of AD, especially a paternal history of AD ( P = 0.048 and P = 0.004, respectively). Facial (periorbital, ear, and cheek) lesions, periauricular fissures, hand/foot eczema, and xerosis were associated with infancy-onset group. The earlier the onset of AD, the poorer the quality of life ( P = 0.038). Systemic immunosuppressants were used in only 9.6% of the patients in the severe group. Conclusion This study analyzed the clinical features of AD in Korean children and adolescents through a multicenter nationwide study and demonstrated the phenotypic differences according to onset age and severity. Considering the findings that the early-onset group is more severe and accompanied by more systemic allergic diseases, early management should be emphasized in young children and infants. ...

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“…Over 80% of patients in dermatology clinics with AD and psoriasis suffer from chronic itch (19,20). About half of patients in dermatological clinics with AD have a high level of depressive disorders, which is more than 3.5 times higher than in the general population (5,21,22). The level of anxiety in adult patients with AD is positively correlated with the intensity of itch (23).…”

Section: Association Of Dermatological Itch Stress and Mental Disordersmentioning

confidence: 99%

Psychologic interventions in patients with the chronic dermatologic itch in atopic dermatitis and psoriasis: A step forward with family constellations seminars

et al. 2022

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Chronic itch is a complex psychophysiological sensation, which can severely affect the quality of life in patients with atopic dermatitis and psoriasis. Itch depends on the irritation of receptors in the skin and the processing of sensory information in the central nervous system. Severe itch leads to activation and later on to disruption of the stress response, resulting in disorders of skin repair, functional and microstructural changes in the areas of the central nervous system that are responsible for the perception of itch. Psychosocial stress can be an essential factor, activating neurohumoral mechanisms which lead to increased itch and scratch, exacerbating skin damage. Patients with chronic itch often have sleep disorders, increased irritability, and depletion of the nervous system. They are characterized by disrupting social relationships, high incidence of anxiety, depressive disorders, and suicidal tendencies. Psychological methods of intervention can effectively influence various mechanisms in the pathogenesis of itch and scratch and improve social functioning in patients with chronic dermatological itch. In this mini-review, we discuss family constellation seminars as an effective method of psychological intervention that can reduce the intensity of itch, and improve sleep and performance in patients with atopic dermatitis and psoriasis. This method is insufficiently described in previous reviews of psychological interventions in atopic dermatitis and psoriasis patients. The positive impact of family constellations seminars in patients with chronic dermatological itch may be related to reducing stress by improving understanding of the family situation, appropriate management of family secrets, and enhancing interactions with the social environment.

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Factors Associated with Affective Symptoms and Quality of Life in Patients with Atopic Dermatitis

Cited by 20 publications

References 56 publications

Women’s quality of sleep and in vitro fertilization success

Women’s quality of sleep and in vitro fertilization success

Clinical Characteristics of Atopic Dermatitis in Korean School-Aged Children and Adolescents According to Onset Age and Severity

Psychologic interventions in patients with the chronic dermatologic itch in atopic dermatitis and psoriasis: A step forward with family constellations seminars

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