Factors associated with anaemia in kidney transplant recipients in the first year after transplantation: a cross-sectional study

Lim, Andy; Kansal, Arushi; Kanellis, John

doi:10.1186/s12882-018-1054-7

Cited by 18 publications

(10 citation statements)

References 32 publications

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“…The prevalence of anemia at 12 months posttransplant in our cohort was 23.5%, similar to the results of previous studies [4,9,12,23]. We observed a slight decline in prevalence between 6 and 12 months, which is in concordance with the findings of other authors [4,9,12].…”

Section: Discussionsupporting

confidence: 93%

Histopathological Features of Time-Zero Kidney Biopsy Are Predictive Factors for Posttransplant Anemia

Mokos¹,

Jurić²,

Mokos³

et al. 2023

Kidney Blood Press Res

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Introduction: Posttransplant anemia (PTA) is a common complication of kidney transplantation, associated with reduced graft survival and higher mortality. We aimed to determine the association of PTA with histopathological characteristics of time-zero allograft biopsy and donor clinical characteristics. Methods: We conducted a retrospective, observational cohort study that included 587 patients who underwent kidney transplantation in our center. Hemoglobin levels were assessed at 6 and 12 months after transplantation, and anemia was defined according to World Health Organization criteria. The kidney allograft time-zero biopsy has been done in all investigated cases. The evaluated histopathological parameters of the kidney allografts included glomerulosclerosis, arteriolar hyalinosis (AH), vascular fibrous intimal thickening (CV), interstitial fibrosis, tubular atrophy, and interstitial fibrosis and tubular atrophy. The Banff Classification of Allograft Pathology criteria were followed to assess the allograft histopathological changes. Results: The prevalence of anemia was 31.3% at 6 months after transplantation and 23.5% at 12 months. There was an association between 20-50% glomerulosclerosis and PTA in both time points, independently from estimated glomerular filtration rate. AH and interstitial fibrosis were identified as independent risk factors for anemia 6 months after transplantation. Conclusion: Histopathological features of time-zero kidney biopsy may be predictors of PTA. Among them, our study recognized 20–50% degree of glomerulosclerosis, AH, and CV as the most significant risk factors for PTA.

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Section: Discussionsupporting

confidence: 93%

Histopathological Features of Time-Zero Kidney Biopsy Are Predictive Factors for Posttransplant Anemia

Mokos¹,

Jurić²,

Mokos³

et al. 2023

Kidney Blood Press Res

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“…Imoagene [31], in the United States, indicated as a protective factor for anemia at one year, the male sex (OR 0.4, CI95% 0.2-0.6), data that agrees with the risk that we identified for the female sex (OR 1.42, CI95 % 1.05-1.91). Similar results were published by Mix [33] (OR 3.61 with 95% CI 1.60-8.15) and other authors [33][34][35][36], including a recent article by Cruz-Santiago y cols. [37], within one of the hospitals that participated in our study.…”

Section: Resultssupporting

confidence: 86%

Risk factors for anemia after one year of kidney transplantation

Adame¹,

Pérez²,

Santiago³

et al. 2021

Trends in Transplant

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Post renal transplant anemia (PTA) occurs in one out of every four patients and, by itself, increases mortality by six times at 10 years. The risk factors associated with its presence, during the first year, have been reported in some investigations with populations, generally different from Latin America. Therefore, a retrospective, longitudinal study was carried out that included 1,438 kidney transplant patients over six years in two public Medical Centers in Mexico. There were 39 deaths (2.7%) and 44 graft losses (3.1%) before one year of follow-up, who left the study. In the 1,355 cases that continued, a prevalence of anemia of 15.5% (n = 210) was found at 12 months. In the bivariate analysis with the PTA at one year, the cadaveric origin of the graft resulted in an OR of 2.24, 95% CI (1.65-3.05) and for creatinine (Cr)> 2.0mg / dL at 6 months, OR of 4.18, 95% CI (2.66-6.56). With Cr> 2.0mg / dL; At 12 months, an OR of 5.55 was obtained, 95% ). Height, baseline Cr, as well as female sex, had a statistically significant relationship with the outcome. In the multivariate model performed, the cadaveric donor, the female sex, and the Cr> 2.0mg / dL at 6 and 12 months predicted anemia at one year. It is concluded that Cr> 2.0 mg / dL, the female sex and the cadaveric graft are the main risk factors for anemia, one year after kidney transplantation.

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“…However, hyperhomocysteinemia associated with CKD is not in itself a recommended indication for folate and/or B12 supplementation [ 2 ]. With kidney transplantation, erythropoietin secretion is restored; however, patients are still prone to anemia [ 66 ]. Again, there are no specific dietary guidelines for anemic KTx recipients; hence, incases of iron deficiency, patients should increase its dietary intake, for example, by incorporating more meat, legumes, nuts, and vegetables such as broccoli into their diet [ 67 ].…”

Section: Vitamin Deficiency In Ktxmentioning

confidence: 99%

Nutrition Disturbances and Metabolic Complications in Kidney Transplant Recipients: Etiology, Methods of Assessment and Prevention—A Review

Górska

Kurnatowska

2022

Nutrients

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Nutrition disturbances occur at all stages of chronic kidney disease and progress with the decrease of the kidney filtration rate. Kidney transplantation (KTx) as the best form of kidney replacement therapy poses various nutritional challenges. Prior to transplantation, recipients often present with mild to advanced nutrition disturbances. A functioning allograft not only relieves uremia, acidosis, and electrolyte disturbances, but also resumes other kidney functions such as erythropoietin production and vitamin D3 metabolism. KTx recipients represent a whole spectrum of undernutrition and obesity. Since following transplantation, patients are relieved of most dietary restrictions and appetite disturbances; they resume old nutrition habits that result in weight gain. The immunosuppressive regimen often predisposes them to dyslipidemia, glucose intolerance, and hypertension. Moreover, most recipients present with chronic kidney graft disease at long-term follow-ups, usually in stages G2–G3T. Therefore, the nutritional status of KTx patients requires careful monitoring. Appropriate dietary and lifestyle habits prevent nutrition disturbances and may improve kidney graft function. Despite many nutritional guidelines and recommendations targeted at chronic kidney disease, there are few targeted at KTx recipients. We aimed to provide a brief review of nutrition disturbances and known nutritional recommendations for kidney transplant recipients based on the current literature and dietary trends.

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Factors associated with anaemia in kidney transplant recipients in the first year after transplantation: a cross-sectional study

Cited by 18 publications

References 32 publications

Histopathological Features of Time-Zero Kidney Biopsy Are Predictive Factors for Posttransplant Anemia

Histopathological Features of Time-Zero Kidney Biopsy Are Predictive Factors for Posttransplant Anemia

Risk factors for anemia after one year of kidney transplantation

Nutrition Disturbances and Metabolic Complications in Kidney Transplant Recipients: Etiology, Methods of Assessment and Prevention—A Review

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