2016
DOI: 10.1016/j.tube.2016.07.006
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Factors associated with anti-TB drug-induced hepatotoxicity and genetic polymorphisms in indigenous and non-indigenous populations in Brazil

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Cited by 11 publications
(8 citation statements)
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“…ADRs occur in 5–33% of all patients receiving oral isoniazid treatment at 300 mg once daily . The metabolic intermediates of isoniazid appear to be the cause of hepatotoxicity . In the liver, isoniazid is first metabolized into acetyl‐isoniazid via N‐acetyltransferase .…”
Section: Introductionmentioning
confidence: 99%
“…ADRs occur in 5–33% of all patients receiving oral isoniazid treatment at 300 mg once daily . The metabolic intermediates of isoniazid appear to be the cause of hepatotoxicity . In the liver, isoniazid is first metabolized into acetyl‐isoniazid via N‐acetyltransferase .…”
Section: Introductionmentioning
confidence: 99%
“…In regard to their general role, GST enzymes are used to metabolize the reactive metabolites produced by CYP2E1, NAT2, and other enzymes. This might be the reason why CYP2E1 alone was not associated with the risk of ATDILI in this study and several reports [36,37,38], because the toxic metabolites could be produced by several molecules mediated through several pathways. Attesting this speculation, in the current study, the combination analysis of CYP2E1 phenotypic polymorphisms and GSTs genetic polymorphisms provided clear results of their associations with ATDILI.…”
Section: Discussionmentioning
confidence: 47%
“…All included articles were observational case‐control studies that investigated GSTs polymorphisms in TB patients with or without ATLI, of which eighteen were conducted in East Asians, eight in Indians, and three in Caucasians and Brazilians, respectively. Most studies used INH, RMP, PZA and EMB for TB treatment, with at least alanine aminotransferase (ALT)/aspartate aminotransferase (AST) more than twice the upper limit of normal (>2 ULN) as the main diagnostic criteria for liver injury.…”
Section: Resultsmentioning
confidence: 99%