Factors associated with antipsychotic use in non-psychotic depressed patients: results from a clinical multicenter survey

Zhou, Jingjing; Tong, Zhu; Zhu, Xuequan; Galling, Britta; Xiao, Le

doi:10.1186/s12888-021-03411-y

Cited by 5 publications

(4 citation statements)

References 36 publications

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“…Comorbidities had some effect on augmentation risk, as reported also by Zhou et al 17 In our study, personality and anxiety disorders and substance abuse slightly increased the risk. It is interesting, that anxiety disorder increased the risk only in persons with moderate depression but not in severe depression.…”

Section: Discussionsupporting

confidence: 87%

“…Among persons suffering from severe depression, 14.0% initiated antipsychotic augmentation. Zhou et al 17 have recently reported slightly higher results, as in their study AP augmentation was initiated to 179 of 834 (21.5%) young adults (18–44 years) with major depressive disorder.…”

Section: Discussionmentioning

confidence: 87%

“…Quetiapine was the most used AP, and its use was twice as common as the second most common option (risperidone). In the study by Zhou et al 17 quetiapine was also the most commonly used AP (43.4%), followed by olanzapine (38.8%). Quetiapine has been reported to be effective in depression, 35 and as it is effective also when treating general anxiety disorder, 36 it may provide additional benefit for patients with anxiety.…”

Section: Discussionmentioning

confidence: 95%

“…Despite the fact that depression is common and AD treatment is commonly modified in young adults, 16 information about factors associated with AP augmentation is greatly limited. Zhou et al 17 have recently published a study of 1503 patients with non‐psychotic depression in adult population, but their study included only 834 persons aged 18–44 years. In this study, we have examined how often an antidepressant medication is augmented with antipsychotics among young adults (aged 18–29 years), and sociodemographic and clinical factors associated with augmentation.…”

Section: Introductionmentioning

confidence: 99%

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Effect of severity of depression on augmentation of antidepressant medication in young adults with depression

Lampela,

Tanskanen,

Lähteenvuo

et al. 2023

Acta Psychiatr Scand

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BackgroundAntipsychotics (AP) have been used to augment antidepressant (AD) medication in treatment‐resistant depression. In this study we examined factors (including severity of depression and initial antidepressant) affecting AP augmentation, as well as which APs were initiated as augmentation in young adults.MethodsData were extracted from Finnish nationwide registers. Of persons aged 18–29 years diagnosed with a depression during 2004–2017 we focused on incident AD users (who initiated AD 6 months before and after the diagnosis) whose severity level of depression was recorded (N = 21,966). AP augmentation was studied during 1 year after diagnosis of depression. Persons diagnosed with severe depression with psychotic features (n = 1486) were excluded from main analyses and analyzed separately.ResultsOverall, 8.4% of new antidepressant users initiated AP augmentation. Risk of augmentation increased with severity of depression as 3.9%, 5.8%, and 14.0% of persons with mild, moderate, and severe depression, respectively, initiated augmentation. Male sex, comorbid anxiety and personality disorders, substance abuse and selfharm/suicide attempt were positively associated with augmentation. Compared to citalopram, use of tricyclic antidepressant, paroxetine and venlafaxine were associated with increased risk of augmentation, while use of bupropion was associated with a decreased risk. Quetiapine and risperidone were the most common APs used in augmentation. Among persons with severe depression with psychotic features, use of sertraline was associated with AP augmentation, whereas use of fluoxetine decreased risk of augmentation.ConclusionsUse of APs as augmentation of AD therapy was common in severe depression. Comorbidities had only a small effect to augmentation, but selection of initial AD was more closely associated to risk of augmentation. Interestingly, use of bupropion decreased risk of augmentation, which warrants further studies, as well as the decrease in risk of augmentation when fluoxetine in case of psychotic depression was used.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of severity of depression on augmentation of antidepressant medication in young adults with depression

Lampela,

Tanskanen,

Lähteenvuo

et al. 2023

Acta Psychiatr Scand

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Comparative study of online learning and face-to-face learning

Sun

2023

SHS Web of Conf.

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Online learning is prompted by the pandemic and has become the second main learning method. Considering the differences between face-to-face (F2F) and online learning, there should be significant differences in students’ learning experiences between the two learning methods. This study uses a course experience questionnaire (CEQ) and an online course experience questionnaire (OCEQ) to investigate and compare students’ perceptions of two learning methods from six factors. The result indicates that the differences between the two learning methods are significant in terms of the total score of the questionnaire, the factor of good teaching (GT), the factor of clear goals (CG) and the factor of appropriate assessment (AA). The lack of social interaction on campus could be the reason for this phenomenon based on the theory of constructionism. That suggests online learning platforms and instructors take more action to increase the interactivity of online learning to motivate students. The difference in the factor of emphasis on independence is not significant, which is inconsistent with the findings from the previous study. The reason could be attributed to the increasing flexibility of the combined learning methods.

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Hypothyroidism and Somatization: Results from E-Mode Patient Self-Assessment of Thyroid Therapy, a Cross-Sectional, International Online Patient Survey

et al. 2023

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BackgroundBetween 10-15% of hypothyroid patients experience persistent symptoms despite achieving biochemical euthyroidism. Unexplained persistent symptoms can be a sign of somatization. This is associated with distress and high healthcare resource use and can be classified as Somatic Symptom Disorder (SSD). Prevalence rates for SSD differ depending on classification criteria and how they are ascertained, varying between 4-25%. As this has not been studied in hypothyroid patients before, the aim of this study was to document somatization in people with hypothyroidism and explore associations with other patient characteristics and outcomes. Methods Online, multi-national, cross-sectional survey of individuals with selfreported, treated hypothyroidism, that included the validated patient health questionnaire-15 (PHQ-15) for assessment of somatization. Chi-

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Factors associated with antipsychotic use in non-psychotic depressed patients: results from a clinical multicenter survey

Cited by 5 publications

References 36 publications

Effect of severity of depression on augmentation of antidepressant medication in young adults with depression

Effect of severity of depression on augmentation of antidepressant medication in young adults with depression

Comparative study of online learning and face-to-face learning

Hypothyroidism and Somatization: Results from E-Mode Patient Self-Assessment of Thyroid Therapy, a Cross-Sectional, International Online Patient Survey

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