Factors Associated with Anxiety and Depression in Korean Patients with Inactive Inflammatory Bowel Disease

Kim, Min Chul; Jung, Yoon Suk; Song, Young Seok; Lee, Jung In; Park, Jung Ho; Sohn, Chong Il; Choi, Kyu Yong; Park, Dong Il

doi:10.5009/gnl15188

Cited by 24 publications

(29 citation statements)

References 45 publications

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“…Epidemiological studies have established that anxiety and depression are the most prevalent psychiatric disorders among IBD patients [ 10 – 13 ]. Also patients suffering from other immune-mediated inflammatory diseases, such as multiple sclerosis or rheumatoid arthitis, are at the increased risk of psychiatric comorbidity [ 14 , 15 ]. The incidence of mood disorders in IBD is not well understood, although the risk of falling for depression or anxiety gets higher, as QoL decreases [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Affective temperament in inflammatory bowel diseases: Another brick in the wall of differentiation

et al. 2018

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Psychiatric disorders are significantly common complications among patients suffering from inflammatory bowel diseases (IBD). Affective temperament is a concept of core personality traits, which can decribe the vulnerability to mood disorders, therefore its evaluation might convey useful information about patients' mental status in autoimmune disorders. The aim of the study was to evaluate the affective temperament in patients with Crohn's disease (CD) and ulcerative colitis (UC) as characteristic features of these diseases, but also in the clinical course and the severity of anxiety and depression.Due to our knowledge this is the first study of this kind. The study enrolled 130 patients with IBD, including 68 with CD and 62 with UC. We used TEMPS-A to evaluate affective temperament and HADS scales to assess the intensity of depressive and anxiety symptoms. Harvey Bradshaw scale, Crohn’s Disease Activity Index (CDAI) and Mayo Score were used to evaluate clinical severity of the diseases. We observed significantly higher prevalence of depressive, cyclothymic and anxiety temperaments in CD patients compared to the control group. Harvey Bradshaw scale, CDAI and Mayo Self Report showed statistically significant outcomes, including significant positive correlations with depressive, cyclothymic and anxiety subscales of TEMPS-A, and negative correlation with the hyperthymic temperament in CD subjects. Our findings indicate significant differences between CD and UC due to temperament traits, and suggest distinct pathogenesis of mood disorders in IBD.

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Section: Introductionmentioning

confidence: 99%

Affective temperament in inflammatory bowel diseases: Another brick in the wall of differentiation

et al. 2018

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“… 7 , 10 Especially within the CD patients, results showed higher frequency for mood disorder compared to the healthy controls. In this study by Kim et al ., 8 the prevalence of anxiety and depression was reported to be high in both quiescent CD and UC patients, suggesting that a significant number of the Korean inactive IBD patients have mood disorder.…”

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confidence: 99%

“…In this issue of Gut and Liver , Kim et al . 8 evaluated the prevalence of anxiety and depression in Korean inactive IBD patients and investigated the predictive factors related with disease and sociodemographic status. A total of 142 IBD patients (75 with ulcerative colitis [UC] and 67 with Crohn’s disease [CD]) completed a self-report questionnaire including the Hospital Anxiety and Depression Score (HADS).…”

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confidence: 99%

The Mental Health State of Quiescent Inflammatory Bowel Disease Patients

Park

Jeen

2016

Gut Liver

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Although some controversies exist, it is well known that psychological disorders are prevalent in patients with inflammatory bowel diseases (IBD). Previous studies have shown that, as with any patients with chronic physical illness, many IBD patients (21% to 35%) present with anxiety and depression.1 During the relapses, it has been reported that more than 80% of patients showed anxiety state and 60% showed depression. 2It has yet to be proven what kind of cause-and-effect relationship exists between IBD and anxiety and depression. These unstable emotional states of IBD patients can aggravate pain and gastrointestinal symptoms by increasing inflammatory activity and lower the patients' quality of life by contributing to feelings of fatigue and decreasing the motivation needed to overcome the disease.3 Therefore, it is important to evaluate the prevalence of anxiety and depression in patients with IBD and to implement an appropriate treatment plan. In previous studies, the factors reported to affect the mood disorders included gender, age, education, socioeconomic deprivation, knowledge score, disease duration, extraintestinal manifestations such as arthritis and stomatitis, use of steroid or immunosuppressants, treatment adherence, disease activity, previous bowel surgery, distribution of inflammation, and disease related quality of life. [4][5][6] However, in Asian countries like Korea, not much research has been conducted on such topics. A recently published study reported that anxiety and depression is common in Korean IBD patients in remission and suggested that appropriate management be provided for these patients. . Because HADS is less influenced by topics related to physical illnesses such as fatigue and wellbeing, it is commonly used to screen mental disorders in IBD patients. Within CD patients, 44% were anxious and 15% were depressed, and within UC patients, 41% were anxious and 24% were depressed. Although there were no healthy matched controls, these prevalence rates were greater than those of the general population in Korea. Some studies found that the amount of psychological distress in IBD patients were associated with disease activity, and the prevalence of anxiety and depression in quiescent IBD patients did not differ significantly from that of the general population.2,9,10 However, irritable bowel syndrome-like symptoms was two to three times more frequent in quiescent IBD patients than in the control group, and this had consistent associations with anxiety and depression. 10 In a recent study on Korean inactive IBD patients, the prevalences of anxiety and depression were 27.4% and 33.6%, respectively, higher than the 26% and 9% previously reported by the Western study using the HADS. 7,10Especially within the CD patients, results showed higher frequency for mood disorder compared to the healthy controls. In this study by Kim et al., 8 the prevalence of anxiety and depression was reported to be high in both quiescent CD and UC patients, suggesting that a significant number of the Korean inact...

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“…The higher prevalence of depressive symptoms in the group of CU patients was shown (24%) as opposed to CD patients (15%) [7]. Relevant differences were found in the prevalence and severity of depressive symptoms depending on the phase of the disease [13].…”

Section: Introductionmentioning

confidence: 80%

“…The symptoms of IBD, as well as their complications (which are often numerous and serious), impair the lives of the patients in a severe way, lowering their quality of life [4][5][6]. The abovementioned is associated with the occurrence of depressive symptoms and anxiety in this group of patients [7].…”

Section: Introductionmentioning

confidence: 99%

Depressive and anxiety symptoms among patients with inflammatory bowel diseases

Bielińska

Liebert

Lesiewska

et al. 2017

Medical Research Journal

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Depressive and anxiety symptoms among patients with inflammatory bowel diseases ABSTRACT Introduction. This study was conducted on a population of patients with inflammatory bowel disease (IBD) and was based on an assessment of the prevalence and severity of depression and anxiety symptoms in various clinical aspects. The psychological features of IBD patients are very important in the perception of symptoms, but crucial as triggers of IBD or as a releasing factor for IBD symptoms recurrence.Methods. The study included 130 patients with IBD, including 68 with Crohn's disease (CD) and 62 with ulcerative colitis (UC). The severity of anxiety and depression symptoms were examined by the Hospital Anxiety and Depression Scale (HADS). Patients were also subjected to assessment of anthropometric attributes, clinical factors, quality of life, and symptoms of the disease, with dedicated clinical scales.Results. The occurrence of significant symptoms of anxiety was estimated at 45.5% in patients with CD and 30.5% in the UC patients. Significant depressive symptoms related to 20.5% of people with CD and 17.5% of patients with UC. The parameters of anxiety and depression showed significant associations with parameters of quality of life, BMI, and the scales describing the exacerbation of the diseases.Conclusions. The analyses did not reveal significant differences in the severity and prevalence of symptoms of anxiety and depression in subgroups with IBD. The expansion of relevant symptoms of anxiety and depression in this population was greater than in the general population. In addition, there was a significant correlation between parameters of HADS and clinical factors.

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Factors Associated with Anxiety and Depression in Korean Patients with Inactive Inflammatory Bowel Disease

Cited by 24 publications

References 45 publications

Affective temperament in inflammatory bowel diseases: Another brick in the wall of differentiation

Affective temperament in inflammatory bowel diseases: Another brick in the wall of differentiation

The Mental Health State of Quiescent Inflammatory Bowel Disease Patients

Depressive and anxiety symptoms among patients with inflammatory bowel diseases

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