Factors associated with atrial fibrillation in patients with hypertension and preserved left ventricle systolic function

Tlegenova, Zhenisgul; Zholdin, Bekbolat; Kudaiberdieva, Gulmira; Abdrakhmanov, Ayan

doi:10.18087/cardio.2617

Cited by 2 publications

(1 citation statement)

References 56 publications

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“…Помимо многососудистого поражения коронарных артерий, для исследуемой группы пациентов характерна сопутствующая патология, осложняющая течение основного заболевания. Чаще всего ИБС в популяции сопутствуют АГ, СД 2 типа, хроническая болезнь почек, метаболический синдром, являющиеся независимыми предикторами развития ФП [9,10]. Однако в нашем исследовании, ввиду строгих критериев отбора пациентов на операцию реваскуляризации миокарда, включающих в себя достижение целевого уровня HbA1c, достижение целевого уровня АД в условиях кардиохирургического отделения, снижение веса, групповых различий по наличию и степени выраженности сопутствующей патологии выявлено не было.…”

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The role of atherosclerotic coronary arteries lesions in development of new-onset atrial fibrillation after coronary artery bypass surgery

et al. 2021

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Aim To study the relationship between the type of circulation, severity and localization of atherosclerotic damage of coronary arteries, results of laboratory and instrumental tests, and historical data in patients with multivascular coronary lesions and atrial fibrillation (AF) that developed after coronary bypass surgery.Material and methods This was a novel, retrospective study of data of patients after elective coronary bypass surgery at the Cardiac Surgery Department #1 of the N.V. Sklifosofsky Research Institute of Emergency Care from December, 2018 through December, 2020. The study included 100 patients. The main group consisted of 20 patients whose early postoperative period (first 7 days after surgery) was complicated with postoperative atrial fibrillation (POAF) (mean age, 65.15±9.7 years). The comparison group included 80 patients without the POAF complication during the early postoperative period (mean age, 62.0±9.16 years). Prior to the coronary bypass surgery, all patients underwent clinical, laboratory, and instrumental examination. Based on data of selective coronary angiography, localization, severity of coronary atherosclerotic damage (according to angiographic classification), number of affected arteries, and the type of circulation were taken into account.Results Intergroup differences in the incidence and localization of myocardial infarctions in history, severity of arterial hypertension in history, class of chronic heart failure (according to the New York Heart Association, NYHA, classification), and heart rate were absent. 100 % of patients had left atrial (LA) dilatation not correlated with the development of AF in the early postoperative period. According to data of coronary angiography, there was no statistically significant association between the type of circulation and the development of POAF. The right type of myocardial blood supply prevailed in patients of both groups. There was no correlation between the severity and localization of coronary atherosclerotic lesions and the development of AF in the early postoperative period.Conclusion The development of AF following coronary bypass surgery was not associated with features of coronary atherosclerotic lesions, which may indicate active development of inter- and intra-systemic anastomoses in patients with long-term history of chronic coronary atherosclerosis.

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The role of atherosclerotic coronary arteries lesions in development of new-onset atrial fibrillation after coronary artery bypass surgery

et al. 2021

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Genetic markers and traditional risk factors in predicting atrial fibrillation in patients with arterial hypertension, focus on the renin-angiotensin-aldosterone system genes

Bukvalnaya,

Yakubova,

Kapytski

et al. 2024

Cardiac Arrhythmias

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BACKGROUND: Genetic and environmental factors are involved in the development of atrial fibrillation in arterial hypertension. This determines the relevance of studying gene-environment interactions in the occurrence of arrhythmia. AIM: To evaluate the contribution of the renin-angiotensin-aldosterone system genes polymorphisms to the susceptibility to atrial fibrillation in patients with arterial hypertension, and also to study the combined influence of these polymorphisms and environmental factors on the risk of arrhythmia. MATERIALS AND METHODS: The study included 60 patients with arterial hypertension and paroxysmal atrial fibrillation (study group), 60 patients with arterial hypertension without atrial fibrillation (comparison group-1) and 20 healthy volunteers (comparison group-2). Angiotensin-converting enzyme (ACE (I/D)) and angiotensin II type 1 receptor gene (AGTR1 (A1166C)) polymorphisms were analyzed by real-time polymerase chain reaction. RESULTS: Genotype II and allele I of the ACE gene (I/D) in patients with arterial hypertension and atrial fibrillation were significantly more frequent compared to patients with arterial hypertension without arrhythmia (χ² = 4.547; p = 0.03 and χ² = 4.818; p = 0.03 respectively). Carriage of genotype II in patients with arterial hypertension increased the chance of developing atrial fibrillation by 2.8 times (95% CI 1.19–7.18). The odds ratio (OR) for arrythmia development in patients with arterial hypertension and allele I was 1.8 (95% CI 1.10–3.07). The presence of obesity in patients with arterial hypertension in the presence of genotype II of the ACE gene (I/D) was associated with an increased risk of developing atrial fibrillation, compared with the genotype alone (OR = 4.16, 95% CI 1.16–19.87). A study of the A1166C polymorphism of the AGTR1 gene did not reveal a reliable significant relationship between its inheritance and the development of atrial fibrillation. CONCLUSION: Genotype II and allele I of the ACE gene (I/D) were statistically significantly more frequent in patients with arterial hypertension and atrial fibrillation. Carriage of genotype II and allele I of the ACE gene (I/D) increased the chance of developing atrial fibrillation in patients with arterial hypertension. Obesity had a significant effect on the susceptibility to atrial fibrillation in the presence of genotype II of the ACE gene (I/D) in hypertensive patients.

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Factors associated with atrial fibrillation in patients with hypertension and preserved left ventricle systolic function

Cited by 2 publications

References 56 publications

The role of atherosclerotic coronary arteries lesions in development of new-onset atrial fibrillation after coronary artery bypass surgery

The role of atherosclerotic coronary arteries lesions in development of new-onset atrial fibrillation after coronary artery bypass surgery

Genetic markers and traditional risk factors in predicting atrial fibrillation in patients with arterial hypertension, focus on the renin-angiotensin-aldosterone system genes

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