Factors Associated With Bleeding Secondary to Rupture of Esophageal Varices in Children and Adolescents With Cirrhosis

Pimenta, Júlio Rocha; Ferreira, Alexandre Rodrígues; Fagundes, Eleonora Druve Tavares; Queiroz, Thaís Costa Nascentes; Baptista, Regiane A.N.; Moreira, E; Resende, Camilo B. de; Bittencourt, Paulo Fernando Souto; Carvalho, Simone Diniz; Neto, José Andrade Franco; Penna, Francisco José

doi:10.1097/mpg.0000000000001362

Cited by 21 publications

(20 citation statements)

References 35 publications

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“…Earlier studies reported incidences ranging from 6.6 to 36%. [24][25][26][27][28][29][30] Our data showed that 24% of the children with BA developed EV bleeding at a median age of 9 months. The incidence seems comparable to earlier studies, while our cohort bled at a slightly younger age than the cohorts mentioned previously.…”

Section: Discussionmentioning

confidence: 58%

Variceal Bleeds in Patients with Biliary Atresia

et al. 2017

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Section: Discussionmentioning

confidence: 58%

Variceal Bleeds in Patients with Biliary Atresia

et al. 2017

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“…To the best of our knowledge, publications even in the recent past in regard to screening high-risk varices with PHT in children have not dealt with Baveno VI criteria. [26][27][28][29][30] However, our foremost weakness was the scarcity of the cACLD cases below 18 years, thus restricting our sample size, which meant that the plan had to be earmarked as a pilot study only. Six children (18.18%), comprising four infants with EHBA and one toddler with PFIC, continued to have high TSB, even after delivering available treatment, at 3 months of enrollment, thus acting as an effect modifier of TE values.…”

Section: Discussionmentioning

confidence: 99%

<p>Validation of Revised Baveno VI Criteria for Screening of Varices Needing Treatment in Children with Cirrhosis</p>

Samanta¹,

Biswas²,

Ghosh³

et al. 2020

CEG

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Background: Baveno VI criteria for screening varices needing treatment (VNT) have not yet been validated in an exclusive pediatric and adolescent set of the population, in whom baseline parameters differ in relation to adults. Therefore, our primary objective was to validate Baveno VI and its expanded form in children below 18 years of age. The secondary aim was to elicit whether any revision of the above criteria with a target of not missing more than 5% VNT could be more accurate for this age group. Materials and Methods: The work was carried out in two medical institutes, over a span of 3 years. Consecutively enrolled patients below 18 years of age, with compensated cirrhosis confirmed by liver biopsy, were evaluated for related blood parameters, transient elastography (TE) and esophagogastroduodenoscopy. Results: Out of the 33 recruited patients, five (15.15%) met the criteria for VNT. The sensitivity, specificity, PPV and NPV of Baveno VI and Expanded Baveno VI were observed as 60%, 92.3%, 60% and 92.3%, and 20%, 100%, 100% and 88%, respectively. We found that the Revised Baveno VI criteria with TE <19 kPa and platelet count of >175×10 9 cells/L, with sensitivity 100%, specificity 79%, PPV 45%, NPV 100% and accuracy of 82%, are more appropriate for this age group. Conclusion: We propose that further multicentrer studies with a larger sample size should be conducted before incorporating Revised Baveno VI criteria for high-risk varices in patients below 18 years in future guidelines.

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“…Therefore, due to the principal role of liver as a detoxification, damage to this organ can be very important [5,6]. There are many causes for cirrhosis of the liver, including long-term alcohol use, hepatitis B, C, and D viruses, followed by inherited diseases such as cystic fibrosis, a1-antitrypsin deficiency, galactosaemia, glycogen storage disease, Wilson syndrome, haemochromatosis, and biliary tract obstruction and biliary atresia in children [4,[7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…Helicobacter pylori (H. pylori) is a non-spore-forming gram-negative microaerophilic bacterium [9]. Helicobacter pylori is the most common chronic bacterial infection in humans and has infected half of the world's population.…”

Section: Introductionmentioning

confidence: 99%

Association between Helicobacter pylori infection and cirrhosis in children

Zahmatkeshan¹,

Matani²,

Asadian³

2019

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Introduction: Liver cirrhosis is often accompanied by fibrosis, loss of liver function, and liver cancer. Identification of the factors associated with this disease has always been a goal because they can be effective in its treatment. Several reports showed that Helicobacter pylori (H. pylori) can cause multiple gastrointestinal complications. Aim of the research: To investigate the association between H. pylori infection and liver cirrhosis in children. Material and methods: In this case-control study, 60 children under the age of 18 years with liver cirrhosis participated as the cases, and 236 healthy children were included as controls. For evaluation of the H. pylori antigen (Ag) of the samples, fresh stool samples were prepared. Results: Thirty-two (53.3%) samples in the cases, and 46 (19.5%) samples in controls had positive H. pylori Ag test. The results showed that the two groups had significant differences in terms of infection by H. pylori stool antigen; the presence of this Ag in the case samples was more than in the controls (p < 0.001). Conclusions: That the rate of H. pylori infection in children with cirrhosis was significantly higher than among healthy children. This result can indicate the effect of this bacterium on the incidence and development of liver cirrhosis. Streszczenie Wprowadzenie: Zwłóknienie, utrata funkcji wątroby, a także rak wątroby często towarzyszą marskości wątroby. Zawsze określano czynniki związane z marskością, ponieważ może się to okazać skutecznym podejściem w leczeniu. Wyniki szeregu badań wykazały, że Helicobacter pylori (H. pylori) może być przyczyną licznych powikłań żołądkowo-jelitowych. Cel pracy: Zbadanie związku między zakażeniem H. pylori i marskością wątroby u dzieci. Materiał i metody: W badaniu kliniczno-kontrolnym wzięło udział 60 dzieci w wieku do 18 lat (grupa badana) oraz 236 zdrowych dzieci (grupa kontrolna). Wykonano badanie próbek kału na obecność antygenu (Ag) H. pylori. Wyniki: Pozytywne wyniki na obecność antygenu H. pylori uzyskano w przypadku 32 (53,3%) próbek pochodzących od chorych dzieci i 46 (19,5%) próbek od grupy kontrolnej. Na podstawie wyników stwierdzono różnice między tymi grupami pod względem zakażenia H. pylori; wykazano większą częstość występowania antygenu w grupie badanej w porównaniu z grupą kontrolną (p < 0,001). Wnioski: Częstość występowania zakażenia H. pylori u dzieci chorych na marskość była istotnie większa niż w grupie zdrowych dzieci. Wynik ten wskazuje na wpływ bakterii na występowanie i rozwój marskości wątroby.

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Factors Associated With Bleeding Secondary to Rupture of Esophageal Varices in Children and Adolescents With Cirrhosis

Cited by 21 publications

References 35 publications

Variceal Bleeds in Patients with Biliary Atresia

Variceal Bleeds in Patients with Biliary Atresia

<p>Validation of Revised Baveno VI Criteria for Screening of Varices Needing Treatment in Children with Cirrhosis</p>

Association between Helicobacter pylori infection and cirrhosis in children

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