Factors Associated with Candidemia Caused by Non‐<i>albicans Candida</i>Species Versus<i>Candida albicans</i>in the Intensive Care Unit

Chow, Jennifer; Golan, Yoav; Ruthazer, Robin; Karchmer, Adolf W.; Carmeli, Yehuda; Lichtenberg, Deborah A.; Chawla, Varun; Young, Janet; Hadley, Susan

doi:10.1086/529435

Cited by 208 publications

(180 citation statements)

References 42 publications

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“…33 It was observed that central venous cat heter exposure was associated with increased risk of BSI due to non-albicans Candida species and total parenteral nutrition was associated with a decreased risk of BSIs due to non-albicans Candida species compared with Candida species. However, in supplementary study it was concluded that there are multiple common risk factors for both albicans and non-albicans Candida BSIs and it is not possible to differentiate between these two groups based on clinical characteristics alone.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of fungal infections in critical care setting of a tertiary care teaching hospital in North India: a prospective surveillance study

Singh¹,

Kashyap²,

Ahluwalia³

et al. 2014

JCSR

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Background: During recent years, fungal infections have risen exponentially and are a cause of significant morbidity and mortality in hospitalized patients, especially in the critical care setting. There is paucity of data from India on fungal pathogens. Methods:We prospectively studied patients admitted to medical and surgical critical care section of a tertiary care institute in northern India. The clinical samples of patients were processed in Department of Microbiology for isolation and identification of fungi by using standard protocols over a period of one year. The patients were categorized into fungal infection and colonization groups. The demographic data and risk factors for fungal infection and colonization were evaluated.Results: Ninety one (82.7%) of the 110 patients enrolled in the study, had fungal infection, whereas 19 (17.3%) had fungal colonization. Candida were isolated from 85/91 (93.4%) and 19/19 (100%) patients with fungal infection and colonization respectively. There was predominance of non-albicans Candida spp both in fungal infection 61/85 (71.7%) patients as well as fungal colonization group 16/19 (84.2% ). In non-albicans Candida spp., Candida tropicalis was the most common isolate observed in both fungal infection (85.3%) and fungal colonization (63.1%) groups. Overall, in patients with fungal infection, candiduria was detected in 68/91 (74.7%) whereas candidaemia was observed in 19/ 91 (20.8%) patients. The risk factors for fungal infections included urinary catheterization (85.7%), central line insertion (81.3%), mechanical ventilation (52.7%), use of corticosteroids (23.1%), total parentral nutrition (6.6%) and peritoneal dialysis (3.3%). Conclusions:The emergence of non-albicans Candida similar to the trends in the western countries should be a cause of concern in our country. Proper surveillance of fungal pathogens is important to improve quality of care in critical care setting and measures should be focussed to control these infections, especially in patients with these risk factors.

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Section: Discussionmentioning

confidence: 99%

Epidemiology of fungal infections in critical care setting of a tertiary care teaching hospital in North India: a prospective surveillance study

Singh¹,

Kashyap²,

Ahluwalia³

et al. 2014

JCSR

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“…Urinary tract infection (UTI) is one of the most common types of nosocomial infections (Schaberg et al, 1991;Tamura et al, 2003) and more than 80 % of nosocomial UTIs are related to the use of medical devices such as urinary catheters (Febré et al, 1999;Harris et al, 1999;Douglas, 2002;Chow et al, 2008). Furthermore, Candida species are responsible for around 80 % of fungal infections in the hospital environment and 10-15 % ofinfections (Kojic & Darouiche, 2004).…”

Section: Introductionmentioning

confidence: 99%

Silicone colonization by non-Candida albicans Candida species in the presence of urine

Silva

Negri

Henriques

et al. 2010

Journal of Medical Microbiology

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Urinary tract infections (UTIs) are the most common nosocomial infections and 80 % are related to the use of urinary catheters. Furthermore, Candida species are responsible for around 15 % of UTIs and an increasing involvement of non-Candida albicans Candida (NCAC) species (e.g. Candida glabrata, Candida tropicalis and Candida parapsilosis) has been recognized. Given the fact that silicone is frequently used in the manufacture of urinary catheters, the aim of this work was to compare both the adhesion and biofilm formation on silicone of different urinary clinical isolates of NCAC species (i.e. C. glabrata, C. tropicalis and C. parapsilosis) in the presence of urine. Several clinical isolates of NCAC species recovered from patients with UTIs, together with reference strains of each species, were examined. Adhesion and biofilm formation were performed in artificial urine and the biofilm biomass was assessed by crystal violet staining. Hydrophobicity and surface charge of cells was determined by measuring contact angles and zeta potential, respectively. The number of viable cells in biofilms was determined by enumeration of c.f.u. after appropriate culture. The biofilm structure was also examined by confocal laser scanning microscopy (CLSM). The results showed that all isolates adhered to silicone in a species-and strain-dependent manner with C. parapsilosis showing the lowest and C. glabrata the highest levels of adhesion. However, these differences in adhesion abilities cannot be correlated with surface properties since all strains examined were hydrophilic and exhibited a similar zeta potential. Despite a higher number of cultivable cells being recovered after 72 h of incubation, stronger biofilm formation was not observed and CLSM showed an absence of extracellular polymeric material for all isolates examined. In summary, this work demonstrated that all tested NCAC species were able to adhere to and survive on silicone in the presence of urine. Furthermore, C. glabrata strains presented higher colonization abilities than C. tropicalis and C. parapsilosis strains, a fact that might explain the larger role of C. glabrata colonization and disseminated infections in hospitalized and catheterized patients. INTRODUCTIONNosocomial infections constitute a serious public health problem, as they are a major cause of morbidity and mortality, and cause an increased time of hospitalization with associated enhanced healthcare costs (Tamura et al., 2003). Urinary tract infection (UTI) is one of the most common types of nosocomial infections (Schaberg et al., 1991;Tamura et al., 2003) and more than 80 % of nosocomial UTIs are related to the use of medical devices such as urinary catheters (Febré et al., 1999;Harris et al., 1999;Douglas, 2002;Chow et al., 2008). Furthermore, Candida species are responsible for around 80 % of fungal infections in the hospital environment and 10-15 % of UTIs are caused by these micro-organisms (Amer et al., 2004). Although the majority of infections are caused by Candida albicans (Richards et a...

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“…OR IC95% P A-OR IC95% P Se encontró que el principal agente causal de candidemia fue Candida albicans predominando sobre las especies no albicans; resultado que concuerda con los reportados por otros estudios realizados en nuestro país (15,20,21), y los descritos en otras investigaciones similares (22-24) realizadas en otros países, no obstante, difi eren a los reportados por Horn et al (3), quienes en una cohorte de 2009 pacientes con candidemia reportaron a las especies no albicans como agente causal en el 54,4% de los pacientes, pese a la presencia predominante de estas especies que pudo ser causada por la presión selectiva ejercida sobre Candida albicans por el uso previo de fl uconazol, el cual fue descrito por Chow et al (25) como factor de riesgo para candidemia por especies no albicans.…”

Section: Variableunclassified

Influencia de la colonización de vía aérea por Candida spp. en pacientes con Enfermedad Pulmonar Obstructiva Crónica en una unidad de cuidado intensivo de Colombia, durante el periodo 2010 a 2015.

Fandiño¹,

Caicedo²,

Urrutia-Gómez

et al. 2017

rev cuarzo

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ResumenCandida spp. es el agente más comúnmente aislado de origen fúngico en el contexto de Unidad de Cuidados Intensivos (UCI), La EPOC es una enfermedad caracterizada por una obstrucción crónica del flujo aéreo pulmonar, constituye un factor predisponente de colonización de la vía aérea por Candida spp. Metodología: Se realizó un estudio de caso comparativo de tipo retrospectivo revisando los registros microbiológicos de aislamientos de muestras orotraqueales de Candida spp entre 2010 y 2015 de pacientes con diagnóstico espirométrico de EPOC, el grupo de comparación fue formado por pacientes con aislamiento de Candida spp. sin diagnóstico de EPOC, se revisó la historia clínica en busca de variables, demográficas, clínicas, terapéuticas y microbiológicas. Las variables discretas se describieron mediante frecuencia relativa y absoluta, mientras que las variables continuas se describieron mediante promedio e IC del 95%. Resultados: 116 pacientes fueron incluidos, 43 en el grupo de EPOC y 73 pacientes en grupo de comparación. No hubo diferencias significativas entre las especies aisladas, siendo el más prevalente Candida albicans con 76.74% de los aislamientos de los pacientes con EPOC y 75.34% de Pacientes sin EPOC, los pacientes con EPOC eran de mayor edad comparados con los de no-EPOC y presentaron un mayor Índice de Charlson comparado con el otro grupo. Dentro de las condiciones clínicas no se observaron diferencias significativas entre los grupos; sin embargo, se presentó mayor mortalidad en los pacientes con EPOC con un 53.49% comparado con el 20.55% del otro grupo de estudio (p<0.01). Conclusión: La colonización por Candida spp se hace relevante como un factor asociado a aumento de la mortalidad en pacientes con. EPOC en contexto de UCI.

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Factors Associated with Candidemia Caused by Non‐albicans CandidaSpecies VersusCandida albicansin the Intensive Care Unit

Cited by 208 publications

References 42 publications

Epidemiology of fungal infections in critical care setting of a tertiary care teaching hospital in North India: a prospective surveillance study

Epidemiology of fungal infections in critical care setting of a tertiary care teaching hospital in North India: a prospective surveillance study

Silicone colonization by non-Candida albicans Candida species in the presence of urine

Influencia de la colonización de vía aérea por Candida spp. en pacientes con Enfermedad Pulmonar Obstructiva Crónica en una unidad de cuidado intensivo de Colombia, durante el periodo 2010 a 2015.

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