Factors associated with carotid intima-media thickness and carotid plaques in type 2 diabetic patients

Cardoso, Claudia R.L.; Marques, Carlos E.C.; Leite, Nathalie C.; Salles, Gilles

doi:10.1097/hjh.0b013e328352aba6

Cited by 29 publications

(35 citation statements)

References 35 publications

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“…Age is well established as a predictor of CCA IMT in subjects with type 1[10,22] and type 2 diabetes[23]. In addition, weight was a positive predictor of CCA IMT in this study, independent of sex, and has been previously associated with CCA IMT in cohorts with and without diabetes[24,25].…”

Section: Discussionsupporting

confidence: 71%

“…Univariate analysis showed male sex was non-significantly associated with greater mean ( P = 0.12) and mean maximum ( P = 0.089) CCA IMT. Previously it has been shown that male sex is associated with greater CCA IMT in people with diabetes[23,24]. Univariate analysis showed that smoking pack years was weakly positively associated with mean and mean maximum CCA IMT but this correlation did not persist after adjustment for age and weight.…”

Section: Discussionmentioning

confidence: 82%

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Clinical and dietary predictors of common carotid artery intima media thickness in a population with type 1 and type 2 diabetes: A cross-sectional study

Petersen¹,

Keogh²,

Meikle³

et al. 2017

WJD

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AIMTo determine the clinical and dietary predictors of common carotid artery intima media thickness (CCA IMT) in a cohort of subjects with type 1 and type 2 diabetes.METHODSParticipants with type 1 (n = 23) and type 2 diabetes (n = 127) had mean and mean maximum CCA IMT measured using B mode ultrasound. Dietary intake was measured using a food frequency questionnaire. Clinical and dietary predictors of mean and mean maximum CCA IMT were determined using linear regression analysis adjusted for potential confounders.RESULTSThe main predictors of mean and mean maximum CCA IMT were age and weight. After multivariate adjustment there were no dietary predictors of CCA IMT. However, in subjects that were not prescribed a lipid lowering medication alcohol consumption was positively associated with CCA IMT after multivariate adjustment. No difference existed in CCA IMT between subjects with type 1 or type 2 diabetes once age was adjusted for.CONCLUSIONCCA IMT was predominantly predicted by age and weight in these subjects with diabetes. The finding that CCA IMT was not different between people with type 1 and type 2 diabetes warrants further investigation in a larger cohort.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 82%

Clinical and dietary predictors of common carotid artery intima media thickness in a population with type 1 and type 2 diabetes: A cross-sectional study

Petersen¹,

Keogh²,

Meikle³

et al. 2017

WJD

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“…Moreover, this surrogate index of large artery compliance has been demonstrated to predict cardiovascular morbidity and mortality in a variety of populations (3-7). Additionally, increased IMT has also been reported as a risk factor for future cardiovascular events in patients with diabetes or hypertension (8). …”

Section: Introductionmentioning

confidence: 99%

Microalbuminuria is Independently Associated with Arterial Stiffness and Vascular Inflammation but not with Carotid Intima-Media Thickness in Patients with Newly Diagnosed Type 2 Diabetes or Essential Hypertension

et al. 2013

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The association between microalbuminuria (MAU) and the indices of macrovascular complication in patients with newly diagnosed type 2 diabetes (D) or essential hypertension (H) was evaluated. Total 446 patients were classified into four groups according to the urinary albumin-to-creatinine ratio: MAU-D (n = 104), normoalbuminuria (NAU)-D (n = 114), MAU-H (n = 116), and NAU-H (n = 112). The indices of macrovascular complication including arterial stiffness evaluated by pulse-wave-velocity (PWV), carotid intima-media thickness (IMT), and vascular inflammation marked by high-sensitivity C-reactive protein (hsCRP) were assessed. PWV, IMT, and hsCRP were higher in patients with MAU than in those with NAU in both diabetes and hypertension groups. In both MAU-D and MAU-H groups, PWV and hsCRP levels were positively correlated with MAU level (MAU-D: r = 0.47, 0.41, MAU-H: r = 0.36, 0.62, respectively, P < 0.05). Additionally, PWV and hsCRP were independent factors predicting MAU (diabetes group: OR 1.85, 1.54, hypertension group: OR 1.38, 1.51, respectively, P < 0.001), but not IMT. MAU is independently associated with arterial stiffness and vascular inflammation but not with IMT in patients with newly diagnosed type 2 diabetes or essential hypertension, which emphasizes the importance of proactive clinical investigations for atherosclerotic complications in patients with MAU, even in newly diagnosed diabetes or hypertension.

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“…Cardoso and cols. showed that in patients with diabetes, older age, male sex, smoking status and the results of ambulatory blood pressure monitoring were the main independent predictors of ultrasonographic carotid atherosclerosis (26).…”

Section: Cardiovascular Risk Estimation In Diabetesmentioning

confidence: 98%

Estimation of cardiovascular risk and detection of subclinical carotid atheromatosis in patients with diabetes without a history of cardiovascular disease

Masson¹,

Francesca²,

Molinero³

et al. 2017

Arch. Endocrinol. Metab.

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Objectives: Cardiovascular risk estimated by several scores in patients with diabetes mellitus without a cardiovascular disease history and the association with carotid atherosclerotic plaque (CAP) were the aims of this study. Materials and methods: Cardiovascular risk was calculate using United Kingdom Prospective Diabetes Study (UKPDS) risk engine, Framingham risk score for cardiovascular (FSCV) and coronary disease (FSCD), and the new score (NS) proposed by the 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol. Ultrasound was used to assess CAP occurrence. A receiver operating characteristic (ROC) analysis was performed. Results: One hundred seventy patients (mean age 61.4 ± 11 years, 58.8% men) were included. Average FSCV, FSCD and NS values were 33.6% ± 21%, 20.6% ± 12% and 24.8% ± 18%, respectively. According to the UKPDS score, average risk of coronary disease and stroke were 22.1% ± 16% and 14.3% ± 19% respectively. Comparing the risks estimated by the different scores a significant correlation was found. The prevalence of CAP was 51%, in patients with the higher scores this prevalence was increased. ROC analysis showed a good discrimination power between subjects with or without CAP. Conclusion: The cardiovascular risk estimated was high but heterogenic. The prevalence of CAP increased according to the strata of risk. Understanding the relationship between CAP and scores could improve the risk estimation in subjects with diabetes. Arch Endocrinol Metab. 2017;61(2):122-9.

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Factors associated with carotid intima-media thickness and carotid plaques in type 2 diabetic patients

Cited by 29 publications

References 35 publications

Clinical and dietary predictors of common carotid artery intima media thickness in a population with type 1 and type 2 diabetes: A cross-sectional study

Clinical and dietary predictors of common carotid artery intima media thickness in a population with type 1 and type 2 diabetes: A cross-sectional study

Microalbuminuria is Independently Associated with Arterial Stiffness and Vascular Inflammation but not with Carotid Intima-Media Thickness in Patients with Newly Diagnosed Type 2 Diabetes or Essential Hypertension

Estimation of cardiovascular risk and detection of subclinical carotid atheromatosis in patients with diabetes without a history of cardiovascular disease

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