Factors Associated with Compliance in Submitting 24-Hour Urine Collections in an Underserved Community

Ghiraldi, Eric; Reddy, Madhumitha; Li, Tianyu; Lawler, Andrew C; Friedlander, Justin I.

doi:10.1089/end.2016.0594

Cited by 20 publications

(10 citation statements)

References 12 publications

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“…Any association between patient age and adequacy of collection was also not found [4]. In a study of adult stone formers in an underserved area, Ghiraldi et al demonstrated that African American patients were half as likely to submit an initial 24-h urine specimen compared with Caucasian patients [6]. No association between race and adequacy of collection was found although the study sample included very few non-Caucasian patients.…”

Section: Discussionmentioning

confidence: 92%

“…The region of residence, type of comorbid illness, and type of physician were significantly associated with completion [5]. Ghiraldi et al found that 43% of adult stone patients living in an underserved, urban area submitted 24-h urine specimens [6]. Caucasians and those with a family history of stone disease were more likely to submit a specimen than African Americans and those without a family history [6].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Initial collection of an inadequate 24-hour urine sample in children does not predict subsequent inadequate collections

Chan

Moser

Whittam

et al. 2019

Journal of Pediatric Urology

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Initial collection of an inadequate 24-hour urine sample in children does not predict subsequent inadequate collections

Chan

Moser

Whittam

et al. 2019

Journal of Pediatric Urology

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“…While 24‐h urine collections remain the only commercially available test method of managing patients to prevent stone recurrence, they are not an ideal solution. They are limited by patient non‐adherence as they are cumbersome for patients to perform accurately . Additionally, they are expensive and may not correlate with the clinical endpoint of future stone recurrence .…”

Section: Discussionmentioning

confidence: 99%

Non‐radiological assessment of kidney stones using the kidney injury test (KIT), a spot urine assay

Yang

Sarwal

et al. 2020

BJU International

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A total of 136 spot urine samples from 98 individuals, with and without kidney stone disease, were processed in a predefined assay to measure six DNA and protein markers in order to generate a risk score for the non-invasive detection of nephrolithiasis. From this cohort, 56 individuals had spot, non-timed urine samples collected at the time of radiographically confirmed kidney stones, and 54 demographically matched, healthy controls without kidney stone disease also provided spot, non-timed urine samples. Sixteen individuals with persistent stone disease had more than one urine sample. Using a proprietary microwell-based KIT assay, we measured cell-free DNA (cfDNA), methylated cfDNA, clusterin, creatinine, protein and CXCL10. A KIT stone score was computed across all markers using the prior locked KIT algorithm. The KIT stone score, with a scale of 0 to 100, was then correlated with demographic variables, kidney stone burden, obstructive kidney stone disease, and urine solutes in 24-h urine collections. ResultsThe scaled KIT stone score, a composite of all six biomarkers, readily discriminated individuals with current or prior radiographically confirmed kidney stones from healthy controls without kidney stone disease (P < 0.001). In individuals with nephrolithiasis, KIT stone score also correlated with radiologically measured stone size (P = 0.017) and differentiated patients with a clinical radiological diagnosis of obstructive nephrolithiasis associated with upper renal tract dilatation (P = 0.001). Stone burden as assessed by KIT stone score, however, did not correlate with the any of the traditional measures of 24-h urine solutes or the 24-h urine supersaturation levels. In patients with persistent stone disease, where multiple urine samples were collected over time and after different interventions, the use of KIT stone score could non-invasively track stone burden over time through a spot urine, non-timed urine sample. ConclusionsA random, spot urine-based assay, KIT stone score, can noninvasively detect, quantify and monitor current stone burden, and may thus minimize radiographic exposure for kidney stone detection. The KIT stone score assay may also help monitor stone recurrence risk for patients with nephrolithiasis, without the requirement for 24-h urine collections.

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“…A clinical report is generated and sent to physicians in approximately 1 to 2 weeks; repeat collections are common and necessary for monitoring treatment response. Despite guideline recommendations from the American Urological Association and the European Association of Urology, 24-hour urine testing is not adopted widely in clinical practice because of the cost of testing, cumbersome collection procedures, and delay in obtaining the results (6,7). There is an urgent need to develop rapid, low-cost, and effective diagnostic approaches for performing multiplex metabolic evaluation of high-risk popula-tions and for providing rapid feedback on urinary responses to dietary or pharmacologic treatments at the point of care.…”

Section: Introductionmentioning

confidence: 99%

SLIPS-LAB—A bioinspired bioanalysis system for metabolic evaluation of urinary stone disease

Shkolyar

Wang

et al. 2020

Sci. Adv.

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Urinary stone disease is among the most common medical conditions. Standard evaluation of urinary stone disease involves a metabolic workup of stone formers based on measurement of minerals and solutes excreted in 24-hour urine samples. Nevertheless, 24-hour urine testing is slow, expensive, and inconvenient for patients, which has hindered widespread adoption in clinical practice. Here, we demonstrate SLIPS-LAB (Slippery Liquid-Infused Porous Surface Laboratory), a droplet-based bioanalysis system, for rapid measurement of urinary stone–associated analytes. The ultra-repellent and antifouling properties of SLIPS, which is a biologically inspired surface technology, allow autonomous liquid handling and manipulation of physiological samples without complicated sample preparation procedures and supporting equipment. We pilot a study that examines key urinary analytes in clinical samples from patients with urinary stone. The simplicity and speed of SLIPS-LAB hold the potential to provide actionable diagnostic information for patients with urinary stone disease and rapid feedback for responses to dietary and pharmacologic treatments.

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Factors Associated with Compliance in Submitting 24-Hour Urine Collections in an Underserved Community

Abstract: In our underserved patient population, AA patients were half as likely to submit a 24-hour urine collection than Caucasian patients, whereas patients with a positive family history of stones were more than twice as likely to submit than patients with no family history.

Cited by 20 publications

References 12 publications

Initial collection of an inadequate 24-hour urine sample in children does not predict subsequent inadequate collections

Initial collection of an inadequate 24-hour urine sample in children does not predict subsequent inadequate collections

Non‐radiological assessment of kidney stones using the kidney injury test (KIT), a spot urine assay

SLIPS-LAB—A bioinspired bioanalysis system for metabolic evaluation of urinary stone disease

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